Bioactivity of Natural Compounds: From Plants to Humans, 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 701
Special Issue Editor
Interests: diabetes mellitus; obesity; age-related diseases; advanced glycation end products (AGEs); medicinal plants; enzyme activity; pharmacokinetics; ADMET; pharmacotherapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Bioactive natural compounds are secondary metabolites isolated from plants and marine organisms that can influence the human body and can also act as beneficial agents against disease. The use of isolated active compounds versus crude extracts allows one to define the precise dosage of the principle useful to induce efficacy. Studies on isolated compounds can support the use of natural products in traditional medicine and can drive the discovery of new active compounds that can be further developed as drugs.
Biologically active compounds are divided into three main classes, such as phenolic, terpene, and nitrogen compounds. Several compounds in these groups may be beneficial in cardiovascular diseases. Endothelial dysfunction is involved in several human diseases, including arteriosclerosis, arterial stiffness, vascular thrombosis, and many others. Among all, soluble adhesion molecules, such as E-selectin, ICAM-1, and VCAM-1, and factors of the coagulation pathway, such as Willebrand factor and soluble thrombomodulin, in addition to various cytokines, such as IL-6, IL-8, IL-12, and C-reactive protein, are involved in vascular dysfunction. Furthermore, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are implicated in tissue damages. Therefore, the search for new agents that can selectively inhibit markers of cardiovascular damage is especially interesting in the development of new drugs.
In this Special Issue, we welcome research articles and reviews on the identification of new active compounds of natural origin, as well as compounds already known for which new mechanisms of action or new activities are highlighted. Studies on natural compounds, both in vitro and in vivo, are of interest.
Dr. Guglielmina Froldi
Guest Editor
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Keywords
- natural compounds
- blood vessel
- endothelium dysfunction
- advanced glycation end products (AGEs)
- reactive oxygen species (ROS)
- cytokines
- ADMET properties
- pharmacokinetics
- gender difference
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Related Special Issue
- Bioactivity of Natural Compounds: From Plants to Humans in Molecules (17 articles)
