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Novel Methodologies of Organic Synthesis

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 554

Special Issue Editors


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Guest Editor
College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China
Interests: synthesis methodology; ring-opening reactions; heterocyclic chemistry; radical chemistry

E-Mail Website
Guest Editor
Department of Chemistry and Chemical Biology, Indiana University Indianapolis, Indianapolis, IN 46202, USA
Interests: organic synthesis; catalysis; photochemistry/photoredox catalysis; metal carbene/carbenoid chemistry; transition metal catalysis; heterocycles synthesis

Special Issue Information

Dear Colleagues,

Synthetic chemistry contributes to the ability to enact substance creation in a concise and chemospecific fashion, which is an important support for the development of multifarious disciplines in modern society. Efficient and precise new reactions, methods, and techniques are the cornerstone of "ideal synthesis". How to develop efficient, economical, safe, and green synthesis methods is the eternal subject of synthetic chemistry. Owing to the significance of synthetic chemistry and the fast, advanced progress in organic synthesis, this Special Issue will provide up-to-date information on the novel methodologies of organic synthesis.

The expectation and goal of this Special Issue is to collect original research papers on synthetic methodologies, new reactions, methods and technologies, functional organic molecules, reaction mechanisms, and more. In this Special Issue, both communications as well as research articles and reviews are welcome.

Dr. Yao Zhou
Dr. Yongming Deng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic synthesis
  • new synthesis methodology
  • green synthesis
  • photocatalysis
  • electrocatalysis
  • transition-metal catalysis
  • asymmetric synthesis
  • heterocyclic synthesis

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Published Papers (1 paper)

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Research

22 pages, 2638 KiB  
Article
Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones
by Hui Sun, Li-Heng Yang, Meng-Yun Fu and Bin Cui
Molecules 2025, 30(5), 1114; https://doi.org/10.3390/molecules30051114 - 28 Feb 2025
Viewed by 316
Abstract
A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones. The strategy involved widening the activation energy of the main reaction and side reaction through intermolecular interactions, thereby increasing the chemoselectivity of the [...] Read more.
A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones. The strategy involved widening the activation energy of the main reaction and side reaction through intermolecular interactions, thereby increasing the chemoselectivity of the domino reaction. In the proposed α-functionalization reaction, TMSCF3 acted as an excellent reagent which increased the nucleophilicity of DMF through the Van der Waals force and reduced the nucleophilicity of H2O through a hydrogen bond. We found that TMSCF3 can increase the activation energy difference between the main reaction and side reaction using DFT calculations, which greatly increased chemoselectivity and avoided the formation of by-products. TMSCF3 was recycled by rectification, and the average recovery rate was 87.2%. DFT calculations, XRD experiments, and control experiments were performed to support this mechanism. We are confident that this strategy has the potential to deliver significant practical advancements while simultaneously fostering broader innovation in the field of domino synthesis. Full article
(This article belongs to the Special Issue Novel Methodologies of Organic Synthesis)
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