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Molecules
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10th Anniversary of Organometallic Chemistry Section
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10th Anniversary of Organometallic Chemistry Section

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: closed (31 December 2025) | Viewed by 1989

Special Issue Editors

Prof. Dr. Alistair Lees

E-Mail Website
Guest Editor
Department of Chemistry, Binghamton University, State University of New York, Binghamton, NY 13902-6000, USA
Interests: organometallic photochemistry; transition-metal photophysics; photoreactivity
Dr. Isabella Rimoldi

E-Mail Website
Guest Editor
Department of Pharmaceutical Science, University of Milan, Via Golgi 19, 20133 Milan, Italy
Interests: organometallic chemistry; asymmetric catalysis; hybrid catalysts; transition metal-based anticancer drugs
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue celebrates the 10th Anniversary of the Organometallic Chemistry Section. It will highlight all aspects of organometallic chemistry, focusing on compounds that feature at least one bond between a metal atom and a carbon atom of an organic molecule. The metal center may belong either to the main group metals or to the transition group. Initially, research in this field centered primarily on catalysis, both homogeneous and heterogeneous, as well as in the synthesis of fine chemicals and pharmaceuticals. Organometallic catalysts are widely employed in the efficient and selective synthesis of active pharmaceutical ingredients (APIs). Furthermore, several organometallic compounds have demonstrated therapeutic potential, with applications as anticancer, antibiotic, and antifungal agents and even in the treatment of neurodegenerative diseases. Over time, the scope has broadened significantly to include applications in materials science, such as the use of organometallic compounds in the development of semiconductors, OLEDs, and metal–organic frameworks (MOFs).

The primary focus of this Special Issue will be to underscore the central role of organometallic chemistry as a dynamic and interdisciplinary field that bridges inorganic and organic chemistry, with critical contributions to both fundamental research and industrial innovation.

Prof. Dr. Alistair Lees
Dr. Isabella Rimoldi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metal complexes
  • metal dyes
  • metal based-drugs
  • catalysis
  • metal compounds in therapy
  • materials science

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Published Papers (3 papers)

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Research

23 pages, 4957 KB  
Article
Electrocatalytic Hydrogen Evolution Using Cyano-Substituted Triaryl Corrole Antimony(III) Complexes
by Yuan-Yuan Wang, Ting-Long Wu, De-Yu Guo, Hao Zhang, Yan-Mei Sun, Li-Ping Si and Hai-Yang Liu
Molecules 2026, 31(5), 789; https://doi.org/10.3390/molecules31050789 - 26 Feb 2026
Viewed by 541
Abstract
Developing molecular electrocatalysts with controllable and predictable properties remains a central challenge in hydrogen evolution reaction (HER) catalysis. Herein, four Sb(III) corrole complexes (1–4) bearing zero to three p-cyano-substituted meso-phenyl groups (-CN Ph) were synthesized to investigate [...] Read more.
Developing molecular electrocatalysts with controllable and predictable properties remains a central challenge in hydrogen evolution reaction (HER) catalysis. Herein, four Sb(III) corrole complexes (1–4) bearing zero to three p-cyano-substituted meso-phenyl groups (-CN Ph) were synthesized to investigate the effect of electron-withdrawing substituents on their catalytic HER performance, in which complexes 2–4 are newly reported. All prepared complexes were well characterized via UV–vis, NMR, HRMS, and XPS. SEM–EDS and UV–vis analyses indicated their uniform dispersion and excellent stability under organic and neutral aqueous solvent electrolysis conditions. When using TsOH as the proton source in DMF, complex 4 exhibited the highest activity with a TOF of 42.19 s−1 at an overpotential of 895 mV. In mixed aqueous–organic media, the Faradaic efficiency of complex 4 reached 85.5%. The HER activity increases with the increasing number of cyano groups, and this observation has been rationalized via DFT calculations, which indicates a ligand-centered reduction and supports a possible ECEC pathway for the HER. These results highlight that cyano functionalization can modulate the electronic properties of Sb(III) corroles, thereby enhancing HER performance. This is helpful for designing efficient Sb(III) corrole-based HER catalysts. Full article
(This article belongs to the Special Issue 10th Anniversary of Organometallic Chemistry Section)
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13 pages, 1719 KB  
Article
Assessment of the Biological Properties of N-Nonsubstituted Succinimides and Their Metallocarbonyl Complexes in Normal and Cancer Cells
by Michał Juszczak, Paulina Tokarz, Aneta Kosińska, Bogna Rudolf and Katarzyna Woźniak
Molecules 2026, 31(1), 121; https://doi.org/10.3390/molecules31010121 - 29 Dec 2025
Viewed by 383
Abstract
Succinimide derivatives display a broad spectrum of biological activities and are being explored for various medical applications, including the treatment of epilepsy, diabetes, and cancer, as well as cardiovascular and liver diseases. Ongoing research continues to yield new derivatives with promising therapeutic potential. [...] Read more.
Succinimide derivatives display a broad spectrum of biological activities and are being explored for various medical applications, including the treatment of epilepsy, diabetes, and cancer, as well as cardiovascular and liver diseases. Ongoing research continues to yield new derivatives with promising therapeutic potential. This study evaluates the biological properties of 3-methoxysuccinimide (1), 3-butynyloxysuccinimide (2), and their metallocarbonyl complexes (η5-cyclopentadienyl)Fe(CO)2(η1-N-(3-methoxysuccinimidato)) (3) and (η5-cyclopentadienyl)Fe(CO)2(η1-N-(3-butynyloxysuccinimidato)) (4) in normal peripheral blood mononuclear cells (PBM) and HL-60 leukemic cells. We examined cytotoxicity, genotoxicity, oxidative, and antioxidative potential of these compounds. Succinimides and their complexes exhibited low cytotoxicity in both cell lines in the concentration range 3–50 μM. At 100 μM, only 3-methoxysuccinimide (1) reduced PBM cell viability, while all compounds significantly decreased HL-60 cell viability at this concentration. We also showed that all compounds caused a minor concentration-independent increase in DNA damage level. Interestingly, complex 3 was significantly less genotoxic for HL-60 cells compared to N-nonsubstituted analog (1). Succinimides 1 and 2 and their metallocarbonyl complexes 3 and 4 demonstrated strong antioxidant properties, especially in HL-60 cancer cells. They also restored SOD activity reduced by oxidative stress in cancer cells. Full article
(This article belongs to the Special Issue 10th Anniversary of Organometallic Chemistry Section)
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18 pages, 2563 KB  
Article
D-Penicillamine/Dihydroquercetin Dual-Loaded Metal–Organic Framework as a Microenvironment Copper Regulator for Enhancing the Therapeutic Efficacy of Polyphenolic Antioxidant in Alzheimer’s Disease
by Xuhan Wu, Gang Huang, Licong Chen, Yiling Xie, Qi Ding, Enpeng Xi, Yun Zhao and Nan Gao
Molecules 2026, 31(1), 111; https://doi.org/10.3390/molecules31010111 - 28 Dec 2025
Cited by 1 | Viewed by 683
Abstract
Polyphenols like dihydroquercetin, rutin, and rifampicin show promise for Alzheimer’s disease (AD) therapy due to their ability to inhibit amyloid-β (Aβ) aggregation and reduce reactive oxygen species (ROS), garnering significant recent interest. However, their efficacy is substantially diminished because excess metal ions present [...] Read more.
Polyphenols like dihydroquercetin, rutin, and rifampicin show promise for Alzheimer’s disease (AD) therapy due to their ability to inhibit amyloid-β (Aβ) aggregation and reduce reactive oxygen species (ROS), garnering significant recent interest. However, their efficacy is substantially diminished because excess metal ions present in amyloid plaques can chelate these compounds. Therefore, reshaping the metal microenvironment in the patient’s brain is particularly important for the therapeutic effect of AD. To address the above issues, we have constructed a composite system formed by NH2-MIL-101(Fe) (MOF), dihydroquercetin (DHQ), and D-penicillamine (D-pen). Due to the lack of π-π interaction and the low adsorption energy between D-pen/MOF, the release order and speed of D-pen was much faster than DHQ, thus achieving metal microenvironment regulation and ensuring the therapeutic effect of DHQ. In a 5 × FAD transgenic mouse model, DD@MOF treated and improved spatial learning and memory deficits. Therefore, the DD@MOF based on polyphenolic compounds provides a potential research direction for intervention in Alzheimer’s disease through chelating copper ions and antioxidant properties. Full article
(This article belongs to the Special Issue 10th Anniversary of Organometallic Chemistry Section)
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