Heterocycles: Synthesis, Biological Activity, Pharmacokinetic Profiles, and Mechanism of Actions
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 3553
Special Issue Editors
Interests: medicinal chemistry; chemical biology; drug design and discovery; anticancer; antimalarial; histone methyltransferase inhibitor; target protein degradation; CYP1B1 inhibitor
Interests: chemistry of DNA binding compounds; synthetic chemistry; organofluorine chemistry; heterocyclic chemistry; bioorganic and medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Interests: drug design; medicinal chemistry; chemical biology; anticancer drugs; anti-infective drugs; enzyme inhibitors; protein–protein interaction (PPI) inhibitors; PROTACs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Natural and synthetic heterocycles have long been recognized for their diverse structural frameworks and significant pharmacological activities, making them privileged scaffolds in drug design and discovery. This Special Issue aims to scrutinize recent advancements in the synthesis, structural modification, structure–activity relationship (SAR) studies, and biological evaluation of heterocyclic compounds and/or heterocycle-based metal complexes. We invite contributions that present innovative synthetic methodologies, rational design strategies, lead optimization, novel heterocyclic scaffolds inspired by natural products, pharmacokinetic evaluations, and their applications in developing therapeutic agents for various human diseases, including cancer, malaria, bacterial/viral infections, neurodegenerative disorders, and more. Additionally, this Special Issue seeks to highlight emerging trends in mechanistic insights of heterocyclic compounds. Submissions may include original research articles, comprehensive reviews, and short communications that contribute to the expanding knowledge in this dynamic and ever-evolving field. We hope that this Special Issue will serve as a valuable resource for researchers, academics, and professionals involved in medicinal chemistry, drug design, and drug discovery.
Dr. Guang Huang
Prof. Dr. Lucjan Strekowski
Dr. Xin Li
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- heterocycles
- privileged scaffold
- inhibitors
- metal complexes
- biological activity
- SAR
- ADMET
- drug design and discovery
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