Heterocycles: Synthesis, Biological Activity, Pharmacokinetic Profiles, and Mechanism of Actions

Dear Colleagues,

Natural and synthetic heterocycles have long been recognized for their diverse structural frameworks and significant pharmacological activities, making them privileged scaffolds in drug design and discovery. This Special Issue aims to scrutinize recent advancements in the synthesis, structural modification, structure–activity relationship (SAR) studies, and biological evaluation of heterocyclic compounds and/or heterocycle-based metal complexes. We invite contributions that present innovative synthetic methodologies, rational design strategies, lead optimization, novel heterocyclic scaffolds inspired by natural products, pharmacokinetic evaluations, and their applications in developing therapeutic agents for various human diseases, including cancer, malaria, bacterial/viral infections, neurodegenerative disorders, and more. Additionally, this Special Issue seeks to highlight emerging trends in mechanistic insights of heterocyclic compounds. Submissions may include original research articles, comprehensive reviews, and short communications that contribute to the expanding knowledge in this dynamic and ever-evolving field. We hope that this Special Issue will serve as a valuable resource for researchers, academics, and professionals involved in medicinal chemistry, drug design, and drug discovery.

Dr. Guang Huang
Prof. Dr. Lucjan Strekowski
Dr. Xin Li
Guest Editors

Manuscript Submission Information

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