Organic Synthesis of Carbohydrates

A special issue of Molbank (ISSN 1422-8599). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 2752

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Guest Editor
Center for Highly Advanced Integration of Nano and Life Sciences (G- CHAIN), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
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Special Issue Information

Dear colleagues,

The major bottleneck in carbohydrate research is the limited availability of biologically important oligosaccharides. For the elucidation of their biological functions, efficient synthetic methodologies in oligosaccharide synthesis are necessary in this research field. Therefore, this Special Issue of Molbank focuses on “Organic Synthesis of Carbohydrates”. We encourage authors to submit short papers that cover the synthesis of novel carbohydrate-based compounds and improved preparation methods of mono- and disaccharide building blocks for oligosaccharide synthesis. The development of glycosylation methods and protecting groups for carbohydrates are also welcome.

Dr. Hidenori Tanaka
Guest Editor

Manuscript Submission Information

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Keywords

  • carbohydrate-based compound
  • oligosaccharide synthesis
  • building block
  • glycosylation
  • protecting group

Published Papers (1 paper)

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Research

5 pages, 367 KiB  
Short Note
6R/S-deutero-α-d-mannopyranoside 1-phosphate
by Sanaz Ahmadipour and Gavin J. Miller
Molbank 2019, 2019(3), M1068; https://doi.org/10.3390/M1068 - 27 Jun 2019
Viewed by 2468
Abstract
6R/S-deutero-α-d-mannopyranoside 1-phosphate was synthesised from a C6 aldehydic mannose thioglycoside donor in four steps. Using NaBD4 as the reductant, isotopic enrichment at C6 was achieved and the resultant C6-deuterated material was converted through to the glycosyl [...] Read more.
6R/S-deutero-α-d-mannopyranoside 1-phosphate was synthesised from a C6 aldehydic mannose thioglycoside donor in four steps. Using NaBD4 as the reductant, isotopic enrichment at C6 was achieved and the resultant C6-deuterated material was converted through to the glycosyl 1-phosphate using a protection/glycosylation/deprotection sequence. The product was fully characterised by 1H, 13C, 31P and 2D NMR, alongside MS analysis. Full article
(This article belongs to the Special Issue Organic Synthesis of Carbohydrates)
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