Feature Paper in Biofilm

A topical collection in Microorganisms (ISSN 2076-2607). This collection belongs to the section "Biofilm".

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Editors


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Collection Editor
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden
Interests: microbial biofilm formation; cyclic di-nucleotide signaling; pathogen-host interaction; protein quality control; Salmonella typhimurium; Pseudomonas aeruginosa; Candida parapsilosis
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Collection Editor
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain
Interests: biofilms; prostheses; infection; devices; catheter
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

This Topical Collection, “Feature Paper in Biofilm”, intends to collect high-quality research articles, short communications, and review articles from all fields of biofilm research. Since the aim of this Topical Collection is to illustrate, through selected works, pioneering research in the field of biofilm, we encourage Editorial Board Members of the Biofilm Section of Microorganisms and beyond to contribute state-of-the-art articles reflecting the latest progress in their research field, or to invite relevant experts and colleagues to do so.

Topics of interest include, but are not limited to:

  • Pathogenesis of biofilms;
  • Biofilm formation of the microbiota;
  • Device-related infections;
  • Chronic tissue-related infections;
  • Innovative strategies for accurate diagnosis of biofilms;
  • Antimicrobial tolerance;
  • New antibacterial approaches;
  • Impact of biofilm formation in biotechnology;
  • Biofilms in nanomedicine.

Prof. Dr. Ute Römling
Dr. María Guembe
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • infections
  • antibiofilm
  • biofilm formation

Published Papers (1 paper)

2025

14 pages, 3325 KiB  
Article
Formation of Mono-Organismal and Mixed Staphylococcus aureus and Streptococcus mutans Biofilms in the Presence of NaCl
by Yusuke Iwabuchi, Hiroko Yoshida, Shuichiro Kamei, Toshiki Uematsu, Masanori Saito and Hidenobu Senpuku
Microorganisms 2025, 13(5), 1118; https://doi.org/10.3390/microorganisms13051118 - 13 May 2025
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Abstract
Staphylococcus aureus, an opportunistic bacterium found in the oral cavity, has been reported as a causative agent of infective endocarditis and pneumonia. Salt is an essential mineral for cell maintenance in the human body. This study was conducted to clarify how salt [...] Read more.
Staphylococcus aureus, an opportunistic bacterium found in the oral cavity, has been reported as a causative agent of infective endocarditis and pneumonia. Salt is an essential mineral for cell maintenance in the human body. This study was conducted to clarify how salt affects the formation of biofilms by S. aureus and Streptococcus mutans, pathogens implicated in dental caries. Bacteria were cultivated with various concentrations of NaCl on a 96-well microtiter plate in tryptic soy broth with 0.25% sucrose or 0.25% glucose (TSBs and TSBg, respectively) for 16 h. The effects of glucosyltransferase in S. mutans membrane vesicles (MVs) and extracellular DNA during biofilm formation were also analyzed. S. aureus biofilms were induced by 0.004–0.25 M NaCl but not by NaCl at concentrations greater than 0.25 M in TSBs. The mixed S. aureus and S. mutans biofilms gradually grew and were constructed by dead cells in a NaCl concentration-dependent manner in both TSBs and TSBg. Moreover, biofilms were slightly induced by glucan generation mediated by the glucosyltransferases in MVs under high-salinity conditions. The formation of mixed-species S. aureus and S. mutans biofilms increased in the presence of both extracellular DNA and MVs. Therefore, extracellular DNA, MVs, and dead cells are factors that promote S. aureus biofilm formation under harsh conditions containing NaCl. The sugar (sucrose and glucose) ingestion-induced S. mutans biofilm may be a risk factor for infection by opportunistic pathogens such as S. aureus in individuals who consume food and drinks containing high concentrations of salt. Full article
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