Gut Microbiota-Brain Axis in Regulation of Feeding Behavior

Dear Colleagues,

I would like to invite you to contribute a paper to a Special Issue focused on the “Gut Microbiota–Brain Axis in Regulation of Feeding Behavior”. We all know the paramount role of the brain in the regulation of feeding behavior. After working for more than 20 years in the field of appetite control, I realized that appetite-regulating brain circuitries are under the influence of gut microorganisms via their direct signaling to neuropeptide receptors and via the immune system. In fact, when we eat, we feed our microorganisms and, in turn, they provide the host with the products of their metabolism necessary for regulation of many physiological functions, including appetite. The molecular nature of such products relevant to appetite should be determined. The mechanisms of altered appetite, such as in patients with eating disorders or in hyperphagic obesity, also remain to be clarified to develop efficient prevention and treatment strategies.

I wish to focus this issue on the interactions in the microbiota gut–brain axis, which may help to clarify the mechanisms of normal or altered appetite and feeding behavior in various pathological conditions and to develop the microbiota-based approaches for treatment of these conditions. In fact, development of the “new generation” probiotics needs clear understanding of their mechanisms of action. The composition of gut microbiota relevant to normal or altered feeding behavior also needs to be understood. I hope that many colleagues will be inspired to look into the role of gut microorganisms in the regulation of feeding behavior and to report their studies in this Special Issue.

Prof. Serguei Fetissov
Guest Editor

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