Special Issue "Helicobacter pylori Infection and Host Defense Mechanism"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editor

Dr. Raffaela Pero
E-Mail Website
Guest Editor
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, 80131 Napoli, Italy
Interests: microbiology; human defensins; Helicobacter pylori; microbiome; genomics; epigetics; cell biology; cancer biology; gene regulation

Special Issue Information

Dear Colleagues,

Helicobacter pylori (H. pylori) is a Gram-negative microaerophilic spiral bacterium previously known as Campylobacter pylori. Since the discovery of H. pylori as a pathogenic infectious agent in humans, it has been linked to different gastric diseases in humans (gastritis, peptic ulcers, gastric adenocarcinoma, and MALT lymphoma).

It colonizes the gastrointestinal mucosa of its host, and in spite of a strong persistent humoral and cellular immune response to H. pylori at the local and systemic level, the organism persists for the lifetime of its host.

The study of the host defense mechanisms factors of the bacteria is key to detection of the molecular and cellular pathways involved and will lead to developing preventive and therapeutic modules in which antibiotic eradication provides a clinical benefit, mainly for gastric diseases.

The increase in the use of antimicrobial therapy has driven to the development and emergence of resistance to the antibiotics used, which leads to a public health problem.

The aim of this Special Issue is to update the biological and clinical concepts of the H. pylori infection.

We warmly invite you to submit your research articles, reviews, and short communications related to the different aspects of H. pylori infection and host defense mechanism: epidemiology, clinical complications, pathogenesis, environmental factors, host genetic susceptibility and immune profile, pattern recognition receptors, cytokines, diagnosis, prevention, and therapy.

Dr. Raffaela Pero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Helicobacter pylori 
  • Virulence factors 
  • Pathogenicity 
  • Human infections 
  • Host–pathogen interactions 
  • Microbiology
  • Antibiotics
  • Antibiotic resistance

Published Papers

This special issue is now open for submission.
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