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Microorganisms
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Sexually Transmitted Infections: Past, Present and Future of the Big...
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Sexually Transmitted Infections: Past, Present and Future of the Big Five

A special issue of Microorganisms (ISSN 2076-2607).

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 9841

Special Issue Editors

Prof. Dr. Servaas A. Morré

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Guest Editor
Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine & Life Sciences, University of Maastricht, 4-6, 6211 LK Maastricht, The Netherlands
Interests: epidemiology; diagnostics; immunogenetics; infectious diseases; valorization and translation; Chlamydia trachomatis
Special Issues, Collections and Topics in MDPI journals
Dr. Elena Ambrosino

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Guest Editor
Institute of Public Health Genomics, Department of Genetics and Cell Biology, Research Institute GROW, Faculty of Health, Medicine & Life Sciences, University of Maastricht, 6229 ER Maastricht, The Netherlands
Interests: international public health; sexual/reproductive health; infectious diseases; immunology; health education
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Sexual and reproductive health (SRH) is an essential component of human well-being. It is important to ensure that every member of society benefits from healthy sexual interactions and is given the opportunity to live their sexuality and to start a family. Improving sexual and reproductive health contributes to healthy and fulfilled populations. Sexually transmitted infections (STIs) are some of the most important threats to this well-being. These can be passed on between a partner that is infected and another who is exposed and susceptible to these infections. STIs can have a vast array of consequences, both in the short and long term.

This Special Issue aims to collect the latest research regarding STIs, especially on CT, NG, TV, MG and syphilis. Original research articles as well as review articles are invited. We also welcome small reviews including history, opinions of the future perspectives, unique case reports, and diagnostics/epidemiology in the developed and the developing world.

Prof. Servaas A. Morré
Dr. Elena Ambrosino  
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chlamydia trachomatis
  • Neisseria gonorrhoeae
  • Trichomonas vaginalis
  • Mycoplasma genitalium
  • Syphilis

Published Papers (3 papers)

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Research

9 pages, 253 KiB  
Article
Genital Chlamydia trachomatis Seroprevalence and Uterine Fibroid Development: Cohort Study of Young African-American Women
by Kristen Moore and Donna Baird
Microorganisms 2022, 10(1), 10; https://doi.org/10.3390/microorganisms10010010 - 22 Dec 2021
Cited by 1 | Viewed by 2234
Abstract
Few studies have investigated the 1930s hypothesis that reproductive tract infections are risk factors for fibroid development. In our 2017 cross-sectional analysis from the Study of Environment, Lifestyle, and Fibroids (2010–2018), a large Detroit community-based cohort of 23–35 year-old African-American women with ultrasound [...] Read more.
Few studies have investigated the 1930s hypothesis that reproductive tract infections are risk factors for fibroid development. In our 2017 cross-sectional analysis from the Study of Environment, Lifestyle, and Fibroids (2010–2018), a large Detroit community-based cohort of 23–35 year-old African-American women with ultrasound fibroid screening, we found an inverse association between seropositivity for genital Chlamydia trachomatis (gCT) infection and fibroids. With prospective data from the cohort (standardized ultrasounds every 20 months over 5 years), we examined gCT’s associations with fibroid incidence (among 1158 women fibroid-free at baseline) and growth. We computed adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incidence by gCT serostatus using Cox proportional hazards models. GCT’s influence on growth was assessed by estimating the difference between fibroid size change for seropositive vs. seronegative between successive ultrasounds (1254 growth measures) using a linear mixed model. Growth was scaled to change over 18 months. GCT seropositivity was not associated with fibroid incidence (aHR, 1.0 95% CI: 0.79, 1.29) or growth (4.4%, 95% CI: −5.02, 14.64). The current evidence based on both biomarker gCT data, which can capture the common undiagnosed infections, and prospective ultrasound data for fibroids suggests that Chlamydia is unlikely to increase fibroid risk. Full article
(This article belongs to the Special Issue Sexually Transmitted Infections: Past, Present and Future of the Big Five)
15 pages, 2035 KiB  
Article
Vaginal Microbiota of the Sexually Transmitted Infections Caused by Chlamydia trachomatis and Trichomonas vaginalis in Women with Vaginitis in Taiwan
by Shu-Fang Chiu, Po-Jung Huang, Wei-Hung Cheng, Ching-Yun Huang, Lichieh Julie Chu, Chi-Ching Lee, Hsin-Chung Lin, Lih-Chyang Chen, Wei-Ning Lin, Chang-Huei Tsao, Petrus Tang, Yuan-Ming Yeh and Kuo-Yang Huang
Microorganisms 2021, 9(9), 1864; https://doi.org/10.3390/microorganisms9091864 - 02 Sep 2021
Cited by 16 | Viewed by 3021
Abstract
The three most common sexually transmitted infections (STIs) are Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC) and Trichomonas vaginalis (TV). The prevalence of these STIs in Taiwan remains largely unknown and the risk of STI acquisition affected by the vaginal microbiota is also elusive. [...] Read more.
The three most common sexually transmitted infections (STIs) are Chlamydia trachomatis (CT), Neisseria gonorrhoeae (GC) and Trichomonas vaginalis (TV). The prevalence of these STIs in Taiwan remains largely unknown and the risk of STI acquisition affected by the vaginal microbiota is also elusive. In this study, a total of 327 vaginal swabs collected from women with vaginitis were analyzed to determine the presence of STIs and the associated microorganisms by using the BD Max CT/GC/TV molecular assay, microbial cultures, and 16S rRNA sequencing. The prevalence of CT, TV, and GC was 10.8%, 2.2% and 0.6%, respectively. A culture-dependent method identified that Escherichia coli and Streptococcus agalactiae (GBS) were more likely to be associated with CT and TV infections. In CT-positive patients, the vaginal microbiota was dominated by L. iners, and the relative abundance of Gardnerella vaginalis (12.46%) was also higher than that in TV-positive patients and the non-STIs group. However, Lactobacillus spp. was significantly lower in TV-positive patients, while GBS (10.11%), Prevotella bivia (6.19%), Sneathia sanguinegens (12.75%), and Gemella asaccharolytica (5.31%) were significantly enriched. Using an in vitro co-culture assay, we demonstrated that the growth of L. iners was suppressed in the initial interaction with TV, but it may adapt and survive after longer exposure to TV. Additionally, it is noteworthy that TV was able to promote GBS growth. Our study highlights the vaginal microbiota composition associated with the common STIs and the crosstalk between TV and the associated bacteria, paving the way for future development of health interventions targeting the specific vaginal bacterial taxa to reduce the risk of common STIs. Full article
(This article belongs to the Special Issue Sexually Transmitted Infections: Past, Present and Future of the Big Five)
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12 pages, 1969 KiB  
Article
The Natural Course of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium in Pregnant and Post-Delivery Women in Pemba Island, Tanzania
by Naomi C. A. Juliana, Abdulla Mbaruk Omar, Jolein Pleijster, Fahad Aftab, Nina B. Uijldert, Said M. Ali, Sander Ouburg, Sunil Sazawal, Servaas A. Morré, Saikat Deb and Elena Ambrosino
Microorganisms 2021, 9(6), 1180; https://doi.org/10.3390/microorganisms9061180 - 30 May 2021
Cited by 8 | Viewed by 3539
Abstract
This study aimed to determine the persistence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking [...] Read more.
This study aimed to determine the persistence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking effort, vaginal swabs were collected at two timepoints during pregnancy and once post-delivery. Detection of CT, NG, TV, and MG was performed by PCR using validated detection kits in samples from 441 pregnant women aged 16–48 years old. Among those, 202 samples were matched during pregnancy and 38 at the second timepoint of the pregnancy and post-delivery CT infection persistence during pregnancy was 100% (n = 11) after an average of eight weeks, that of TV infection 82% (n = 11) after ten weeks, and that of MG infection 75% (n = 4) after ten weeks. Post-delivery (after approximately 22 weeks) infection persistence was 100% for CT (n = 1) and 20% for TV (n = 5). NG was only detected at the last collection timepoint, its persistence rate could not be determined. These results show persistence and clearance of curable infections during and after pregnancy. Analysis of biobanked samples is a valuable approach in the investigation of the natural history of curable pathogens. Full article
(This article belongs to the Special Issue Sexually Transmitted Infections: Past, Present and Future of the Big Five)
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