Research on Relevant Clinical Infections: 2nd Edition

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1364

Special Issue Editors


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Tyrolpath Obrist Brunhuber GmbH, 6511 Zams, Austria
Interests: immunology; longevity research; virology; infectious diseases; innate and adaptive immune response
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Guest Editor
Diagnostic and Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, 8010 Graz, Austria
Interests: tumor biology; molecular pathology and oncology; translation initiation factors; protein aggregation diseases; hematopathology
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Guest Editor
Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria
Interests: bacterial infections; bloodstream infections; molecular diagnostics; antimicrobial resistance; antimicrobial stewardship; infectious diseases; immunology
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our 2024 Special Issue “Research on Relevant Clinical Infections”.

Microbial infections have emerged to cause diseases that can be devastating and sometimes fatal to the host. The four main groups of causative pathogens are viruses, bacteria, fungi, and parasites. Polymicrobial infections caused by combinations of pathogens are a special case and are becoming more popular. In particular, polymicrobial infections in immunocompromised or very elderly populations continue to pose a serious health threat. However, many infectious diseases are caused by bacterial infections which caused very high mortality rates before antibiotics were discovered. Nowadays, the rapid global spread of pathogens that have acquired new antimicrobial resistance mechanisms is a major global health threat, causing difficult-to-treat infections and are therefore of particular interest to researchers in the clinical setting. Besides tremendous infection-induced mortality rates, especially in children, these diseases often cause severe economic burdens due to prolonged hospital stays, hygiene measurements, and sequels. As a result, there is a significant need to study clinical microbial infections and discover novel tools for their diagnosis and treatment.

This Special Issue aims to present resent findings on various aspect of relevant clinical microbial infections. The main focus points include:

  • Epidemiology and clinical features of microbial infections;
  • Infections in special populations / nosocomial infections;
  • Molecular insights into the pathomechanisms of specific infections;
  • Challenges and advances in the treatment of microbial infections;
  • Antimicrobial resistance mechanisms in microbial infections.

Reviews (metanalysis), original research papers, and communications are welcome.

We look forward to your contributions.

Dr. Ludwig Knabl
Prof. Dr. Johannes Haybaeck
Dr. Silke Huber
Guest Editors

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Keywords

  • infectious disease
  • microbial infections
  • clinical relevance
  • rapid diagnosis
  • advanced therapy

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Published Papers (1 paper)

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18 pages, 1378 KiB  
Systematic Review
Fungal Pericarditis—A Systematic Review of 101 Cases
by Predrag Jancic, Stefan Milutinovic, Marshall Ward, Milan Radovanovic, Nikola Jovanovic, Marina Antic, Nikola Nikolajevic, Marija Petrovic, Dorde Jevtic, Adam Adam and Igor Dumic
Microorganisms 2025, 13(4), 707; https://doi.org/10.3390/microorganisms13040707 - 21 Mar 2025
Cited by 1 | Viewed by 978
Abstract
Fungal pericarditis is a rare disease but its incidence has risen in parallel with the global increase in invasive fungal infections. This systematic review analyzes data from previously reported cases of fungal pericarditis to provide an improved understanding of the etiology, clinical presentation, [...] Read more.
Fungal pericarditis is a rare disease but its incidence has risen in parallel with the global increase in invasive fungal infections. This systematic review analyzes data from previously reported cases of fungal pericarditis to provide an improved understanding of the etiology, clinical presentation, management, and outcomes of this rare disease. We reviewed Medline and Scopus databases from 1 January 1990 to 29 January 2024 for case reports that documented the isolation of a fungal pathogen from pericardial fluid or tissue. Of the 2330 articles screened, 101 cases met the inclusion criteria. Patients with fungal pericarditis and the involvement of at least one other organ—usually the lungs, brain, or kidney—had worse outcomes than patients with isolated pericardial disease. Immunosuppression was reported in 50% of cases and was associated with worse outcomes in adults. Patients who presented with chest pain, received adequate empiric antifungal therapy, and underwent pericardiocentesis and pericardiectomy had improved survival. The most common isolated pathogens were Candida spp., followed by Aspergillus spp. and Mucor spp., with the latter two linked to worse outcomes. Only 35% of patients received empiric antifungal medications before the causative pathogen was identified, and mortality was associated with a delay in appropriate therapy. Immunosuppression, disseminated disease, and presence of shock/multiorgan failure were additional risk factors associated with death. Fungal pericarditis carries a mortality rate of up to 50%, with nearly half of patients being immunocompromised. Clinicians frequently do not consider fungal pericarditis in the differential diagnoses, which leads to delays in treatment and poorer outcomes. Further prospective multicenter studies are urgently needed to better understand the epidemiology, improve diagnostic testing and management, and decrease unacceptably high mortality in patients with fungal pericarditis. Full article
(This article belongs to the Special Issue Research on Relevant Clinical Infections: 2nd Edition)
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