Organ-on-Chip for Drug Transport and Bioavailability Assessment

Dear Colleagues,

With the introduction of FDA Modernization Act 3.0, organ-on-a-chip technology can play a significant role in drug testing, helping to bring new, effective, and safe treatments to patients quickly.

We are pleased to invite you to contribute your research to this Special Issue, "Organ-on-Chip for Drug Transport and Bioavailability Assessment." This Special Issue will highlight how readouts from organ-on-a-chip technology can be related to drug transport, bioavailability, and other pharmacokinetic measures commonly reported in drug testing. We welcome submissions covering all organ systems and various diseases. Of particular interest are new detection and analysis methods and the testing of macromolecules (e.g., biologics). In vivo benchmarking data are welcome but not necessary.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• Multi-Organ-on-a-Chip Systems and PK/PD Modeling: Development of fluidically coupled multi-organ systems to model drug absorption, distribution, metabolism, and excretion (ADME) and systemic pharmacokinetics (PK), as well as establishing predictive PK/PD relationships.
• Drug Transport and Biological Barrier Function: Organ-on-a-chip models for critical biological barriers (e.g., blood–brain barrier, gut, lung) to quantify drug permeation and study transport mechanisms and enzyme activities.
• Testing of Macromolecules and Complex Therapies: Application of OOC technology for screening and characterizing macromolecules such as biologics, peptides, antibodies, and patient-specific therapies using iPSCs.
• Novel Detection, Analysis, and AI Integration: Integration of microsensors for real-time monitoring, development of new analytical techniques, and the use of Artificial Intelligence (AI)/Machine Learning for automated chip design and high-throughput drug screening.

I look forward to receiving your contributions. 

Dr. Qin Maggie Qi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.