Versatile Cell Culture Platforms Regulating Stem Cells Fate

Dear Colleagues,

Bioreactors are a “specialized room” that provides the appropriate cell cultures and preservation environment to grow cells and tissues. A versatile cell culture platform, a so called “bioreactor”, can provide the fundamental chemical and mechanical environment to affect kinetics and tissue regenerations. Cells depend heavily on bioelectromechanical forces to maintain their functions: the distributions of nutrients and regulatory factors, and system process control. For these reasons, a bioreactor is a crucial technique and process to create informative platforms of stem cells and tissue structures for clinical purposes or biomedical engineering toolboxes. Bioreactor technology has demonstrated enormous potential in biological and tissue engineering applications due to its outstanding advantages, for example, enhanced functional operation, precious peristaltic flow pumping, dynamic three-dimensional regeneration of tissue culture, and an automated control environment through manufacturing techniques using advanced, state-of-the-art methods. There are many advancements and breakthroughs developing in the academic/industrial community, and there are a few challenges emerging, accordingly, in reactor designs, structures, fabrication, integration, automation, real-time cell monitoring, and applications of bioreactors for all kinds of biological and tissue regeneration. This Special Issue aims to collate and uncover research papers, short communications, perspectives, and insightful review articles from esteemed colleagues that demonstrate (1) original works on the topic of cell culture platforms from the large scale through to the microscale, or cell incubators/3D-printed platforms based on various kinds of flow-induced gradients and stimuli for tissue regeneration; and (2) new developments and potentials of applying bioreactor technology of any kind in biological and tissue regeneration. The objective of this Special Edition is to provide insightful information on dynamic cell culture reactors concerning technological advancements for researchers in the community.

Dr. Ki-Taek Lim
Guest Editor

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• cell culture platform
• stem cell fate
• bioreactor design
• flow-induced gradients and stimuli
• tissue engineering