Electrochemical Biosensors and Bioelectronic Microdevices for Point-of-Care and Wearable Applications

Dear Colleagues,

Electrochemical biosensors have undergone remarkable innovation in recent years, driven by advances in nanomaterials, surface engineering, microfluidic integration, and low-power electronics. These technologies enable the highly sensitive, rapid, and selective detection of biochemical targets across a variety of complex environments, ranging from clinical diagnostics and environmental monitoring to food safety and wearable/implantable health assessment. With their intrinsic advantages—simple instrumentation, miniaturization compatibility, and quantitative output—electrochemical biosensors continue to play a pivotal role in bridging fundamental sensing science with real-world applications.

This Special Issue aims to highlight recent progress, emerging strategies, and future perspectives in electrochemical biosensing. We welcome contributions that address innovations in electrode materials, bio-recognition interfaces, signal transduction mechanisms, wireless data acquisition, and scalable device architectures. Studies demonstrating practical applications, field validation, and translational potential are particularly encouraged.

The scope of this Special Issue includes, but is not limited to, the following topics:

• Sensor Platforms: Novel electrode architectures, nanomaterial-enhanced interfaces, flexible/printed electronics, microfluidic or wearable platforms, and wireless or IoT-integrated systems.
• Signal Transduction & Analysis: Electrochemical detection strategies (amperometry, voltammetry, EIS, ECL, PEC, etc.), noise reduction approaches, multiplexed detection, and AI-assisted signal interpretation.
• Biorecognition & Surface Engineering: Aptamers, enzymes, antibodies, molecularly imprinted polymers, antifouling coatings, and interfacial design for enhanced sensitivity, selectivity, and stability.
• Applications: Point-of-care testing, environmental and food analysis, organophosphorus compounds and heavy metal detection, physiological monitoring (sweat, saliva, and ISF), and next-generation wearable/implantable biosensing systems.

We seek original research articles, reviews, communications, and perspectives that will contribute to advancing the science and technology of electrochemical biosensors across various disciplines. We look forward to receiving your submissions for this Special Issue.

Dr. Shuto Osaki
Prof. Dr. Eiichi Tamiya
Guest Editors

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