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Micromachines
Special Issues
Application of Microfluidic Technology in Biology
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Application of Microfluidic Technology in Biology

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 2124

Special Issue Editors

Dr. Sumit Parvate

E-Mail Website
Guest Editor
Department of Electronic & Electrical Engineering, University College London, London WC1E 7JE, UK
Interests: polymer science; colloids and interfaces; microfluidics; microencapsulation; coatings; energy storage materials
Dr. Goran T. Vladisavljević

E-Mail Website
Guest Editor
Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, UK
Interests: particle generation and manipulation in microfluidic (lab-on-a-chip) devices; microencapsulation; micromixing and chemical synthesis in microreactors; polymer synthesis; healthcare engineering (drug-eluting balloon catheters, controlled drug release, antimicrobial resistance); energy and environment (carbon capture; biodiesel production; membrane separations)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Microfluidic technology has revolutionized biological research by enabling the precise control and manipulation of small volumes of fluids. This technology has facilitated advancements in areas such as cell biology, diagnostics, and drug development. Microfluidic devices allow for high-throughput screening, single-cell analysis, and the creation of complex tissue models, offering unparalleled accuracy and efficiency. The integration of microfluidics in biological applications promises to enhance our understanding of cellular processes and accelerate the development of personalized medicine. This Special Issue aims to explore the latest innovations and applications of microfluidics in biological sciences, highlighting its transformative impact on research and clinical practice.

We look forward to receiving your submissions.

Dr. Sumit Parvate
Dr. Goran T. Vladisavljević
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • lab-on-a-chip
  • single-cell analysis
  • organ-on-a-chip
  • high-throughput screening
  • DNA sequencing
  • personalized medicine
  • synthetic biology
  • real-time analysis
  • diagnostics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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15 pages, 2921 KiB  
Article
Application of Inertial Microfluidics for Isolation and Removal of Round Spermatids from a Spermatogenic Cell Sample to Assist In-Vitro Human Spermatogenesis
by Sabin Nepal, Joey Casalini, Alex Jafek and Bruce Gale
Micromachines 2025, 16(5), 500; https://doi.org/10.3390/mi16050500 - 25 Apr 2025
Viewed by 235
Abstract
In-vitro spermatogenesis holds great potential in addressing male infertility, yet one of the main challenges is separating round spermatids from other germ cells in spermatogonial stem cell cultures. STA-PUT, a method based on velocity sedimentation, has been extensively tested for this application. Though [...] Read more.
In-vitro spermatogenesis holds great potential in addressing male infertility, yet one of the main challenges is separating round spermatids from other germ cells in spermatogonial stem cell cultures. STA-PUT, a method based on velocity sedimentation, has been extensively tested for this application. Though somewhat effective, it requires bulky, expensive equipment and significant time. In contrast, the method of inertial microfluidics offers a compact, cost-effective, and faster alternative. In this study, we designed, fabricated, and tested a microfluidic spiral channel for isolating round spermatids and purifying spermatogenic cells. A commercially available spiral device close to the calculated specifications was tested for rapid prototyping, achieving 79% purity for non-spermatid cells in a single pass, with ability to achieve higher purity through repeated passes. However, the commercial device’s narrow outlets caused clogging, prompting the fabrication of a custom polydimethylsiloxane device matching the calculated specifications. This custom device demonstrated significant improvements, achieving 86% purity in a single pass compared to STA-PUT’s 38%, and that without any clogging issues. Further purification could be attained by repeated passes, as shown in earlier studies. This work underscores the efficacy of inertial microfluidics for efficient, high-purity cell separation, with the potential to revolutionize workflows in in-vitro spermatogenesis research. Full article
(This article belongs to the Special Issue Application of Microfluidic Technology in Biology)
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Review

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17 pages, 1969 KiB  
Review
Microfluidic Technologies in Advancing Cancer Research
by Arjun Ajikumar and Kin Fong Lei
Micromachines 2024, 15(12), 1444; https://doi.org/10.3390/mi15121444 - 28 Nov 2024
Cited by 1 | Viewed by 1559
Abstract
This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells [...] Read more.
This review explores the significant role of microfluidic technologies in advancing cancer research, focusing on the below key areas: droplet-based microfluidics, organ-on-chip systems, paper-based microfluidics, electrokinetic chips, and microfluidic chips for the study of immune response. Droplet-based microfluidics allows precise manipulation of cells and three-dimensional microtissues, enabling high-throughput experiments that reveal insights into cancer cell migration, invasion, and drug resistance. Organ-on-chip systems replicate human organs to assess drug efficacy and toxicity, particularly in the liver, heart, kidney, gut, lung, and brain. Paper-based microfluidics offers an alternative approach to accomplish rapid diagnostics and cell- and tissue-based bioassays. Electrokinetic microfluidic chips offer precise control over cell positioning and behavior, facilitating drug screening and cellular studies. Immune response studies leverage real-time observation of interactions between immune and cancer cells, supporting the development of immunotherapies. These microfluidic advances are paving the way for personalized cancer treatments while addressing challenges of scalability, cost, and clinical integration. Full article
(This article belongs to the Special Issue Application of Microfluidic Technology in Biology)
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