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Micromachines
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The Fabrication of Micro and Nano Bio-Detection Chips, Sensors and...
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The Fabrication of Micro and Nano Bio-Detection Chips, Sensors and Smart Detectors

A special issue of Micromachines (ISSN 2072-666X). This special issue belongs to the section "B：Biology and Biomedicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 4431

Special Issue Editors

Dr. Jinping Luo

E-Mail Website
Guest Editor
State Key Laboratory of Transducer Technology, Institute of Electronics Chinese Academy of Sciences, Beijing 100190, China
Interests: electrochemical biosensors; microfluidic platforms; microelectrode arrays; nerve signal detection; point-of-care testing
Special Issues, Collections and Topics in MDPI journals
Dr. Yang Wang

E-Mail Website
Guest Editor
School of Engineering Medicine, Beihang University, Beijing 100191, China
Interests: biomedical MEMS devices; biosensors; point-of-care testing technique and devices; microfluidic analytical devices; electrochemical detection methods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue titled "The Fabrication of Micro and Nano Bio-Detection Chips, Sensors and Smart Detectors" aims to explore the cutting-edge advancements in the development and application of miniaturized bio-fabrication and bio-detection technologies. With the rapid evolution of biotechnology and materials science, there is a growing need for innovative sensing platforms that can provide accurate, real-time detection of biological analytes at the micro- and nanoscale. This Special Issue invites contributions that focus on novel fabrication techniques, materials development, and integration strategies for bio-detection devices, as well as their application in fields such as healthcare, environmental monitoring, and food safety. We encourage submissions that address both fundamental research and practical applications, highlighting interdisciplinary approaches that enhance the performance and functionality of bio-sensors and smart detectors. By bringing together diverse perspectives and expertise, we aim to foster collaboration and advance the field towards next-generation bio-detection solutions.

Dr. Jinping Luo
Dr. Yang Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bio-detection techniques
  • micro/nano sensors
  • materials sciences
  • novel fabrication techniques
  • biomarker detection
  • interdisciplinary research
  • environmental monitoring
  • food safety

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Published Papers (2 papers)

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Research

11 pages, 3278 KiB  
Article
Highly Sensitive and Specific Lateral Flow Detection for DNA Methylation Based on GIaI-Mediated Specific-Terminal-Mediated Polymerase Chain Reaction
by Lihui Ke, Hang Zhao, Hongbo Shan, Yicheng Chen, Yongsheng Cai, Yang Wang, Bo Wei and Minghua Du
Micromachines 2025, 16(4), 387; https://doi.org/10.3390/mi16040387 - 28 Mar 2025
Viewed by 302
Abstract
Sensitive and specific detection of DNA methylation is crucial for the early diagnosis of various human diseases, particularly cancers. However, conventional methylation detection methods often face challenges in balancing both sensitivity and specificity. In this study, we present a novel approach that integrates [...] Read more.
Sensitive and specific detection of DNA methylation is crucial for the early diagnosis of various human diseases, particularly cancers. However, conventional methylation detection methods often face challenges in balancing both sensitivity and specificity. In this study, we present a novel approach that integrates the high specificity of methylation-dependent restriction endonuclease (GlaI) digestion with the amplification efficiency of specific terminal-mediated polymerase chain reaction (STEM-PCR). This combination enables selective amplification of methylated DNA, which is then detected through lateral flow detection (LFD), providing a simple, visual readout. As a proof of concept, a STEM-PCR-LFD assay was applied to detect methylated Septin 9, a biomarker for colorectal cancer. The assay demonstrated a sensitivity of approximately 0.1% (10 copies of methylated template per reaction), with no cross-reactivity observed when 10,000 copies of unmethylated DNA were included as background. Furthermore, the assay was validated with ten formalin-fixed paraffin-embedded (FFPE) tissue samples, achieving 100% consistency with standard real-time STEM-PCR. This method offers a highly sensitive, specific, and accessible platform for DNA methylation detection, with potential for early disease diagnosis. Full article
(This article belongs to the Special Issue The Fabrication of Micro and Nano Bio-Detection Chips, Sensors and Smart Detectors)
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12 pages, 6820 KiB  
Article
A Robust Normally Closed Pneumatic Valve for Integrated Microfluidic Flow Control
by Minggan Li and Siqin Dong
Micromachines 2025, 16(1), 34; https://doi.org/10.3390/mi16010034 - 29 Dec 2024
Viewed by 1118
Abstract
Accurate fluid management in microfluidic-based point-of-care testing (POCT) devices is critical. Fluids must be gated and directed in precise sequences to facilitate desired biochemical reactions and signal detection. Pneumatic valves are widely utilized for fluid gating due to their flexibility and simplicity. However, [...] Read more.
Accurate fluid management in microfluidic-based point-of-care testing (POCT) devices is critical. Fluids must be gated and directed in precise sequences to facilitate desired biochemical reactions and signal detection. Pneumatic valves are widely utilized for fluid gating due to their flexibility and simplicity. However, the development of reliable normally closed pneumatic valves remains challenging, despite their increasing demand in advanced POCT applications to prevent uncontrolled fluid flow. Existing normally closed valves often suffer from poor reliability and lack precise control over fluid opening pressure, due to the uncontrolled stretching of the elastomer during assembly. In this study, we propose and develop a robust method for normally closed valves. By precisely controlling the pre-stretching of the elastomer, we achieve reliable valve closure and accurate control of the opening pressure. A robust normally closed valve was designed and fabricated, and its pneumatic opening pressure was systematically studied. Experimental validations were conducted to demonstrate the reliability and effectiveness of the proposed design. Full article
(This article belongs to the Special Issue The Fabrication of Micro and Nano Bio-Detection Chips, Sensors and Smart Detectors)
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