Advanced Biosensing Systems: Design, Fabrication and Application

Dear Colleagues,

Biological systems governing the behavior of individual cells, organs, or entire organisms perceive and generate a diverse collection of chemical, electrical, mechanical, thermal, and optical stimuli, where the ability to communicate with them across a multitude of modalities relies on the elaborate microscale machinery of biomolecules and their complexed integration. Exchanges of ions and electrons appearing across the lipid bilayer of cellular membranes, the organelles, and most of the complex and large biomolecules such as proteins and DNA, establish the foundations of inter- and intracellular communications that support essential functions of all living biological systems. The precise modulation of ionic and/or electronic exchange at cellular and subcellular levels with clinical safety and dynamic accuracy can provide promising opportunities in further understanding brain development and treating neurological disorders, as well as in facilitating cardiac regeneration. However, challenges remain in the development of an intimate interface between electronic systems and biological living organisms at cellular and subcellular scales. Advanced platforms with enhanced functionalities and demonstrated utility as interfaces to the brain involve dense arrays of penetrating conductive needles on silicon wafer platforms, distributed collections of passive electrodes on flexible sheets for electrocorticography (ECoG), and linear sets of electrodes on narrow filaments. This Special Issue aims to collect the latest research in these fields, focusing especially on functionalities at the tissue interface and novel mechanical properties device, geometric layouts, and/or integration approaches, which collectively enhance the performance, scalability, specificity, and ability to deploy into or onto biological systems.

Dr. Wubin Bai
Guest Editor

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• bioelectronics
• biosensors
• neural interface
• 3D multiscale systems
• wearable technology