Special Issue "Glycomics and Glycoproteomics"
Deadline for manuscript submissions: closed (20 September 2012).
Interests: Analytical and Bioanalytical methods; Chemical Separation; Glycomics; Glycoproeomics; Proteomics
The importance of posttranslational modifications in modulating the activities and functions of proteins in health and disease is illustrated by the fact that no more than 30,000-50,000 proteins are encoded by the human genome. The importance of protein glycosylation has been reflected in the fact that cell-cell interactions involve sugar-sugar, or sugar-protein specific recognition. Consequently, aberrant glycosylation has now been recognized as the attribute of many mammalian diseases, including hereditary disorders, immune deficiencies, neurodegenerative diseases, cardiovascular disease, and cancer. This special issue will focus on detailing the emerging trends in glycomics and glycoproteomics allowing better understanding of the biological roles of glycans and glycoproteins.
This special issue will consider research papers focused on the analysis and characterization of glycans and glycoproteins to allow better understanding of their biological roles. Novel liquid phase separation methods (HPLC, Nano-LC, gel electrophoresis, CE, CEC, microchip, and microfluidics) combined with all kinds of detection including on line and off line mass spectrometry and laser-induced fluorescence detection or any other type of detection are of high interest for this issue. Papers describing novel sample derivatization, preparation/concentration ,or any enrichment approaches will be considered for publication in this issue.
Dr. Yehia Mechref
- capillary electrophoresis
- lectin affinity chromatography
- glycoprotein enrichment
- computational approaches
- data interpretation