Metabolomics Approaches to Nutrition, Intestine and Farm Animal

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 970

Special Issue Editors


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Guest Editor
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China
Interests: gut microbiota and gut health; mycotoxin; heavy-metal pollution and animal health; bone disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China
Interests: ruminant animal; nutrition; metabolomics; metabolism; gut microbiota
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China
Interests: farm animal; nutrition; metabolomics; metabolism; gut microbiota

Special Issue Information

Dear Colleagues,

Farm animal industries, including poultry, pig, and cattle industries, have experienced explosive growth in the recent decades. This effectively alleviates the protein shortage caused by the increasing population size. Currently, supplementing the diet with nutrients such as probiotics, prebiotics, and traditional Chinese medicine has been shown to enhance the growth, gut microbiota, and metabolism of animals. As biochemical converters, intestine- and gut-residing microorganisms could convert the complicated chemical space presented by the diet and host nutrients in the metabolite environment. These metabolites, such as antimicrobial peptides, vitamins, short-chain fatty acids, and enzymes, exert beneficial effects on the host through multiple complex mechanisms. Utilizing metabolomics methods allows for the detection of changes in metabolites in the liver, kidney, and intestine of farmed animals, enabling the evaluation of their health status.

This Special Issue of Metabolites, ”Metabolomics Approaches to Nutrition, Intestine and Farm Animal”, will investigate the impact of nutrients, including probiotics, prebiotics, and Chinese medicine additives, on the metabolism of farmed animals. By analyzing the alterations in metabolites of farm animals such as cattle, chickens, sheep, and pigs, the regulatory effects of these nutrients on their health will be examined.

Dr. Shu-cheng Huang
Dr. Lihong Zhang
Dr. Aoyun Li
Guest Editors

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Keywords

  • farm animal
  • nutrition
  • metabolomics
  • metabolism
  • gut microbiota

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Published Papers (1 paper)

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Review

31 pages, 2163 KiB  
Review
The Role of Probiotics, Prebiotics, Synbiotics, and Postbiotics in Livestock and Poultry Gut Health: A Review
by Taojing Yue, Yanan Lu, Wenli Ding, Bowen Xu, Cai Zhang, Lei Li, Fuchun Jian and Shucheng Huang
Metabolites 2025, 15(7), 478; https://doi.org/10.3390/metabo15070478 - 15 Jul 2025
Viewed by 588
Abstract
Background: The gut health of livestock and poultry is of utmost importance as it significantly impacts their growth performance, disease resistance, and product quality. With the increasing restrictions on antibiotic use in animal husbandry, probiotics, prebiotics, synbiotics, and postbiotics (PPSP) have emerged as [...] Read more.
Background: The gut health of livestock and poultry is of utmost importance as it significantly impacts their growth performance, disease resistance, and product quality. With the increasing restrictions on antibiotic use in animal husbandry, probiotics, prebiotics, synbiotics, and postbiotics (PPSP) have emerged as promising alternatives. This review comprehensively summarizes the roles of PPSP in promoting gut health in livestock and poultry. Results: Probiotics, such as Lactobacillus, Bifidobacterium, and Saccharomyces, modulate the gut microbiota, enhance the gut barrier, and regulate the immune system. Prebiotics, including fructooligosaccharides, isomalto-oligosaccharides, galactooligosaccharides, and inulin, selectively stimulate the growth of beneficial bacteria and produce short-chain fatty acids, thereby improving gut health. Synbiotics, combinations of probiotics and prebiotics, have shown enhanced effects in improving gut microbiota and animal performance. Postbiotics, consisting of inanimate microorganisms and their constituents, restore the gut microbiota balance and have anti-inflammatory and antibacterial properties. Additionally, the review looks ahead to the future development of PPSP, emphasizing the importance of encapsulation technology and personalized strategies to maximize their efficacy. Conclusions: Our aim is to provide scientific insights for PPSP to improve the gut health of livestock and poultry. Full article
(This article belongs to the Special Issue Metabolomics Approaches to Nutrition, Intestine and Farm Animal)
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