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Metabolites
Special Issues
The Role of Signaling Pathways in Animal Cell Metabolism
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The Role of Signaling Pathways in Animal Cell Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Integrative Metabolomics".

Deadline for manuscript submissions: closed (15 July 2022) | Viewed by 8593

Special Issue Editors

Prof. Dr. Xiaohua Teng

E-Mail Website
Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China
Interests: environmental pollution; toxicology; molecular mechanism; signal pathway; energy metabolism
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Na Dong

E-Mail Website
Guest Editor
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150038, China
Interests: animal molecular nutrition; metabolic regulation; intestinal mucosa immunity; pattern recognition receptor; cell signaling pathways

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a new Special Issue on “The Role of Signaling Pathways in Animal Cell Metabolism” in Metabolites, a peer-reviewed open access journal on metabolism and metabolomic (ISSN 2218-1989). Receptor proteins convert extracellular signals into intracellular signals which are amplified, dispersed, and regulated through the signal cascade. Additionally, a series of cellular reactions finally occur, including regulation of downstream gene expression and changes in intracellular enzyme activity, cellular skeleton type, and DNA synthesis.

This Special Issue focuses on the molecular mechanism of animal cell metabolism, highlighting the signaling pathways and important cell metabolic targets and covering the intracellular chemical reactions that are involved in energy and matter (proteins, nucleic acids, and lipids) under adverse conditions. The in-depth study of the signaling pathway related to cell metabolism is crucial for clarifying the molecular mechanism of cell metabolism under adverse conditions. Our goal is to provide gather works that help to understand the related signaling pathways of cell metabolism.

Prof. Dr. Xiaohua Teng
Prof. Dr. Na Dong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • signaling pathway
  • adverse conditions
  • animal
  • molecular mechanism
  • cell metabolism

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Published Papers (3 papers)

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Research

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19 pages, 4597 KiB  
Article
Untargeted Metabolomics Revealed Potential Biomarkers of Small Yellow Follicles of Chickens during Sexual Maturation
by Jinbo Zhao, Hongbin Pan, Wenjiang Zhao, Wei Li, Haojie Li, Zhongxiao Tian, Dayong Meng, Yuting Teng, Xinlu Li, Yang He, Hongmei Shi, Changrong Ge and Kun Wang
Metabolites 2023, 13(2), 176; https://doi.org/10.3390/metabo13020176 - 26 Jan 2023
Cited by 6 | Viewed by 2871
Abstract
Sexual maturation provides economically important traits in poultry production. Research on the initiation mechanism of sexual maturity is of great significance for breeding high-yield laying hens. However, the underlying mechanisms are not fully clear. Here, one hundred and fifty Chahua No. 2 laying [...] Read more.
Sexual maturation provides economically important traits in poultry production. Research on the initiation mechanism of sexual maturity is of great significance for breeding high-yield laying hens. However, the underlying mechanisms are not fully clear. Here, one hundred and fifty Chahua No. 2 laying hens (the CH2 group, which has precocious puberty) and one hundred and fifty Wu Liang Shan black-bone laying hens (the WLS group, a late-maturing chicken breed) with similar weights and ages were randomly selected. ELISA was used to determine the secretion levels of luteinizing hormone (LH), estradiol (E2), and progesterone (P4) in 150-day-old serum and small yellow follicle (SYF) tissues. A histology examination, immunohistochemistry, and quantitative real-time PCR (qPCR) were used to explore the molecular mechanism of how some genes related to oxidative stress affect sexual maturation. The results showed that the secretion levels of LH, E2, and P4 in the CH2 group serum and SYF were higher than those in the WLS group. The results of the real-time PCR of all genes showed that the expression levels of cytochrome P450 family 11 subfamily A member 1, steroidogenic acute regulatory protein, follicle-stimulating hormone receptor, and cytochrome P450 family 19 subfamily A member 1 in the CH2 group were significantly higher than those in the WLS groups (p < 0.001). Untargeted metabolomics combined with multivariate statistical analysis was used to identify biomarkers of SYF tissues in the CH2 and WLS groups. A trajectory analysis of the principal component analysis (PCA) results showed that the samples within the group were clustered and that the samples were dispersed between the CH2 and the WLS groups, indicating that the results of the measured data were reliable and could be used for further research. Further analysis showed that a total of 319 metabolites in small yellow follicles of the CH2 and WLS groups were identified, among which 54 downregulated differential metabolites were identified. These 54 metabolites were found as potential CH2 biomarkers compared with WLS at 150 days, and the different expressions of L-arginine, L-prolinamide, (R)-4-hydroxymandelate, glutathione, and homovanillic acid were more significant. Twenty metabolic pathways were found when significantly differential metabolites were queried in the KEGG database. According to the impact values of the metabolic pathways, eighteen differential metabolites belonged to the mTOR signaling pathway, glutathione metabolism, ABC transporters, the cell ferroptosis pathway, and D-arginine and D-ornithine metabolism. Interestingly, we identified that the cell ferroptosis pathway played an important role in chicken follicle selection for the first time. The histology and immunohistochemistry of SYF showed that the number of granulosa cells increased in the CH2 groups and the expression levels of glutathione peroxidase 4, tumor protein p53, ribosomal protein S6 kinase, and sterol regulatory element binding protein 1 in the granulosa cell layer were upregulated in the CH2 group at the time of sexual maturation. Furthermore, we also speculated that the antioxidant system may play an indispensable role in regulating sexual maturity in chickens. Overall, our findings suggest differentially expressed metabolites and metabolic pathways between CH2 and WLS chickens, providing new insights into the initiation mechanism of sexual maturation. Full article
(This article belongs to the Special Issue The Role of Signaling Pathways in Animal Cell Metabolism)
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15 pages, 2468 KiB  
Article
Physiological and Metabolic Adaptation to Heat Stress at Different Altitudes in Yaks
by Shuli Yang, Jinfeng Liu, Zhaobing Gu, Ping Liu and Qin Lan
Metabolites 2022, 12(11), 1082; https://doi.org/10.3390/metabo12111082 - 8 Nov 2022
Cited by 7 | Viewed by 1947
Abstract
Yaks have strong adaptability to extremely cold and hypoxic conditions but are susceptible to high ambient temperature when yaks are raised in low-altitude areas during the high-temperature season. Twenty-four adult male yaks with similar weights and ages were randomly divided into TN (Thermoneutral, [...] Read more.
Yaks have strong adaptability to extremely cold and hypoxic conditions but are susceptible to high ambient temperature when yaks are raised in low-altitude areas during the high-temperature season. Twenty-four adult male yaks with similar weights and ages were randomly divided into TN (Thermoneutral, altitude = 3464 m), LHS (Light heat stress, altitude = 1960 m), and MHS (Medium heat stress, altitude = 906 m) groups to evaluate adaptation strategies to HS. Non-targeted and targeted metabolomics were applied to investigate the effects of different extents of HS on yaks. LHS- and MHS-yaks showed higher rectal temperatures and respiratory rates than TN-yaks. MHS-yaks had higher levels of red blood cells (RBCs), hemoglobin (Hb), whole blood relative index of middle shear at a shear rate of 5 S−1 (WMS), whole blood relative index of high shear at a shear rate of 200 S−1 (WHS), Casson viscosity (CV), middle shear flow resistance at a shear rate of 5 S−1 (MSFR), and high shear flow resistance at a shear rate of 200 S−1 (HSFR) as compared to TN- and LHS-yaks. Differential metabolites and metabolic pathways, including fatty acid metabolism, lipid metabolism, glucose metabolism, and amino acid metabolism, were altered by HS. Metabolites in the glucose metabolism pathway in LHS- and MHS-yaks were lower than those in TN-yaks. However, LHS-yaks showed higher levels of metabolites in the HIF-1 signaling pathway compared to TN- and MHS-yaks. Most of the tricarboxylic acid cycle (TCA) intermediates and fatty acids were significantly decreased in MHS-yaks compared to the other two groups. As a whole, yaks raised at a low altitude (25.6 °C) suffered from severe HS, but they adapted to HS with vasodilatation for dissipating heat and the increased antioxidants and metabolite levels of energy substrates. Full article
(This article belongs to the Special Issue The Role of Signaling Pathways in Animal Cell Metabolism)
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Review

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17 pages, 619 KiB  
Review
Nuclear Receptor Pathways Mediating the Development of Boar Taint
by Christine Bone and E. James Squires
Metabolites 2022, 12(9), 785; https://doi.org/10.3390/metabo12090785 - 25 Aug 2022
Cited by 3 | Viewed by 2962
Abstract
The nuclear receptors PXR, CAR, and FXR are activated by various ligands and function as transcription factors to control the expression of genes that regulate the synthesis and metabolism of androstenone and skatole. These compounds are produced in entire male pigs and accumulate [...] Read more.
The nuclear receptors PXR, CAR, and FXR are activated by various ligands and function as transcription factors to control the expression of genes that regulate the synthesis and metabolism of androstenone and skatole. These compounds are produced in entire male pigs and accumulate in the fat to cause the development of a meat quality issue known as boar taint. The extent of this accumulation is influenced by the synthesis and hepatic clearance of androstenone and skatole. For this reason, PXR, CAR, and FXR-mediated signaling pathways have garnered interest as potential targets for specialized treatments designed to reduce the development of boar taint. Recent research has also identified several metabolites produced by gut microbes that act as ligands for these nuclear receptors (e.g., tryptophan metabolites, short-chain fatty acids, bile acids); however, the connection between the gut microbiome and boar taint development is not clear. In this review, we describe the nuclear receptor signaling pathways that regulate the synthesis and metabolism of boar taint compounds and outline the genes involved. We also discuss several microbial-derived metabolites and dietary additives that are known or suspected nuclear receptor ligands and suggest how these compounds could be used to develop novel treatments for boar taint. Full article
(This article belongs to the Special Issue The Role of Signaling Pathways in Animal Cell Metabolism)
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