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Metabolites
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Metabolic and Hormonal Profile of Polycystic Ovary Syndrome: Current Update...
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Metabolic and Hormonal Profile of Polycystic Ovary Syndrome: Current Update and Future Prospects

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 5555

Special Issue Editors

Prof. Dr. Aneta Gawlik

E-Mail Website
Guest Editor
Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, Katowice, Poland
Interests: congenital adrenal hyperplasia; disorder of sex development; Turner syndrome; PCOS
Special Issues, Collections and Topics in MDPI journals
Dr. Karolina Skrzyńska

E-Mail Website
Guest Editor
Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Interests: hyperandrogenism; PCOS; metabolic disorders; thyroid disorders

Special Issue Information

Dear Colleagues,

The diagnosis of polycystic ovary syndrome (PCOS) as the most common cause of hyperandrogenism is difficult and controversial but extremely important due to the long-term consequences of the syndrome. It is a disease that affects many processes in the human body, and not only those directly related to the symptoms of PCOS, as well as increasing the risk of metabolic and cardiovascular diseases. The early presence of traditional as well as other cardiovascular risk factors underscores the need for screening and the appropriate counseling and treatment of patients to prevent future symptomatic cardiovascular diseases.

This Special Issue of Metabolites, entitled “Metabolic and Hormonal Profile of Polycystic Ovary Syndrome”, aims to better understand the hormonal and metabolic profile of women with PCOS, and thus provide additional information about the possible and more frequent occurrence of comorbidities, indicating possible complications and risks from them. It is important to adopt a broad perspective of the prevalence of polycystic ovary syndrome among adolescent girls, as it is a problem that affects a significant percentage of teenagers and women of reproductive age; at the same time, it is a syndrome whose diagnosis and treatment has a significant impact in terms of quality of life, fertility and complications resulting from concomitant metabolic disorders in adulthood. With regard to the most up-to-date reports we invite you to publish papers on this topic, which may help to better understand the etiopathlogy, improving the rules of diagnosis and causal treatment.

Prof. Dr. Aneta Gawlik
Dr. Karolina Skrzyńska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polycystic ovary syndrome
  • metabolic disorders
  • cardiovascular diseases
  • microbiota
  • hyperandrogenism
  • immunity

Published Papers (3 papers)

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Research

11 pages, 274 KiB  
Article
Comparing the Efficacy of Myo-Inositol Plus α-Lactalbumin vs. Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome
by Zdravko Kamenov, Antoaneta Gateva, Simona Dinicola and Vittorio Unfer
Metabolites 2023, 13(6), 717; https://doi.org/10.3390/metabo13060717 - 31 May 2023
Cited by 6 | Viewed by 1664
Abstract
Despite the beneficial effect of myo-inositol on metabolic, hormonal, and reproductive parameters of polycystic ovary syndrome (PCOS) patients, 28% to 38% could be resistant to this treatment. The combination with the milk protein α-lactalbumin can be a useful therapeutic approach to overcome inositol [...] Read more.
Despite the beneficial effect of myo-inositol on metabolic, hormonal, and reproductive parameters of polycystic ovary syndrome (PCOS) patients, 28% to 38% could be resistant to this treatment. The combination with the milk protein α-lactalbumin can be a useful therapeutic approach to overcome inositol resistance and achieve ovulation in these women. This open-label prospective study aimed to compare the effects of supplementing myo-inositol plus α-lactalbumin vs myo-inositol alone on reproductive and metabolic abnormalities in PCOS. A total of 50 anovulatory women with a PCOS diagnosis were randomly assigned to receive myo-inositol alone or a combination of myo-inositol and α-lactalbumin for three months. Anthropometric measures, hormonal levels, and menstrual cycle duration were collected at baseline and after treatment. The therapy with myo-inositol plus α-lactalbumin improved both ovulation rate and menstrual cycle duration more than myo-inositol alone. The body weight was significantly reduced in women receiving myo-inositol plus α-lactalbumin, while patients in the myo-inositol group experienced no change. In addition, the improvement of hyperandrogenism was more prominent in patients treated with myo-inositol plus α-lactalbumin. The benefits of associating myo-inositol and α-lactalbumin clearly make this combination a true edge in the management of PCOS. Full article
(This article belongs to the Special Issue Metabolic and Hormonal Profile of Polycystic Ovary Syndrome: Current Update and Future Prospects)
12 pages, 952 KiB  
Article
Correlation between Selected Clinical Symptoms and Severity of Aggression, Impulsiveness and Their Selected Behavioral Manifestations in Patients with Polycystic Ovary Syndrome Phenotype A
by Aleksandra Barabasz-Gembczyk, Wojciech Mędrala, Patryk Rodek, Barbara Alli-Balogun, Jan Chrobak, Marlena Cwynar, Dominika Sikora, Mariusz Wójtowicz, Grzegorz Franik, Paweł Madej and Krzysztof Kucia
Metabolites 2023, 13(5), 646; https://doi.org/10.3390/metabo13050646 - 9 May 2023
Viewed by 1318
Abstract
Previous studies on aggressiveness and impulsiveness in women with polycystic ovary syndrome (PCOS) are ambiguous. Furthermore, no biochemical or clinical factors related to these variables have been definitively confirmed. The aim of the study was to clarify whether, in women with phenotype A [...] Read more.
Previous studies on aggressiveness and impulsiveness in women with polycystic ovary syndrome (PCOS) are ambiguous. Furthermore, no biochemical or clinical factors related to these variables have been definitively confirmed. The aim of the study was to clarify whether, in women with phenotype A of PCOS, variables such as body mass index and clinical and biochemical hyperandrogenism have an impact on either the intensity of impulsivity or aggression or on other selected behavioral manifestations of these variables. The study included 95 patients diagnosed with PCOS phenotype A. The criterion for recruitment into the study group and the control group was body mass index. The study was conducted with the use of a closed-format questionnaire and calibrated clinical scales. Higher body mass index (BMI) values in women with PCOS phenotype A are associated with poor eating habits. The severity of impulsivity and aggression syndrome, as well as the tendency to engage in risky sexual behavior and patterns of alcohol consumption among patients diagnosed with PCOS phenotype A, are not dependent on BMI. The severity of impulsiveness and the syndrome of aggression in women with phenotype A PCOS are not associated with clinical symptoms of hyperandrogenism or with androgen levels. Full article
(This article belongs to the Special Issue Metabolic and Hormonal Profile of Polycystic Ovary Syndrome: Current Update and Future Prospects)
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16 pages, 5969 KiB  
Article
Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice
by Cynthia Aburto-Hernández, David Barrera, Rosario Ortiz-Hernández, Emilio Espinoza-Simón, Leticia Parra-Gámez, James González, M Luisa Escobar, Gerardo H Vázquez-Nin, Olga Echeverría-Martínez and Nayeli Torres-Ramírez
Metabolites 2022, 12(12), 1182; https://doi.org/10.3390/metabo12121182 - 26 Nov 2022
Cited by 2 | Viewed by 1595
Abstract
Polycystic ovary syndrome (PCOS) is an endocrine–metabolic disorder of unknown etiology. Hyperandrogenism (HA) is the main diagnostic criteria for PCOS, in addition to being a risk factor for developing several disorders throughout the patient’s life, including pregnancy. However, the impact on offspring is [...] Read more.
Polycystic ovary syndrome (PCOS) is an endocrine–metabolic disorder of unknown etiology. Hyperandrogenism (HA) is the main diagnostic criteria for PCOS, in addition to being a risk factor for developing several disorders throughout the patient’s life, including pregnancy. However, the impact on offspring is little known. Therefore, the aim of this work was to evaluate the effect of maternal HA on glucose metabolism and hepatic lipid accumulation in adult offspring. We used Balb/c mice treated with dehydroepiandrosterone (DHEA) for 20 consecutive days. The ovary of DHEA-treated mice showed hemorrhagic bodies, an increased number of atretic follicles, and greater expression of genes related to meiotic cell cycle and DNA repair. The DHEA offspring (O-DHEA) had low birth weight, and some pups showed malformations. However, O-DHEA individuals gained weight rapidly, and the differences between them and the control group became significantly greater in adulthood. Moreover, O-DHEA presented higher serum glucose after a 6 h fast and a larger area under glucose, insulin, and pyruvate tolerance test curves. Oil Red O staining showed a more significant accumulation of fat in the liver but no changes in serum cholesterol and triacylglycerol levels. In summary, our results show that HA, induced by DHEA, affects gene expression in oocyte, which in turn generates defects in embryonic development, insulin resistance, and alteration in hepatic gluconeogenesis and lipid metabolism in O-DHEA, thereby increasing the risk of developing metabolic diseases. Full article
(This article belongs to the Special Issue Metabolic and Hormonal Profile of Polycystic Ovary Syndrome: Current Update and Future Prospects)
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