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Metabolites
Special Issues
Nutritional and Metabolic Diseases in Animals
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Nutritional and Metabolic Diseases in Animals

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 3786

Special Issue Editors

Dr. Yanfeng Xue

E-Mail Website
Guest Editor
College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, China
Interests: integration of mother and child nutrition; lipid and glucose metabolism in the liver; crosstalk of gastro-intestinal microbiota and host
Dr. Xiliang Du

E-Mail Website
Guest Editor
Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi'an Road, Changchun 130062, China
Interests: the molecular mechanism of animal nutritional and metabolic disorders; exploring of therapeutic targets and drugs for liver diseases
Dr. Lizhuang Hao

E-Mail
Guest Editor
Key Laboratory of Plateau Grazing Animal Nutrition and Feed Science of Qinghai Province, Qinghai Academy of Science and Veterinary Medicine of Qinghai University, Xining 810016, China
Interests: Ruminant nutrition and metabolites; nutritional balance omics of Plateau herbivorous livestock system; metab-olites and feed utilization
Special Issues, Collections and Topics in MDPI journals
Dr. Chenxu Zhao

E-Mail Website
Guest Editor
College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China
Interests: subacute rumen acidosis; rumen inflammation; short-chain fatty acid transport in rumen epithelium Ruminant nutrition and metabolites

Special Issue Information

Dear Colleagues,

Nutrition is highly correlated with animal health and production performance. Many metabolic diseases and low productivity are caused by malnutrition (overnutrition and undernutrition), nutrient deficiency, nutritional disorders resulting from environmental factors, genetic factors, nutrient digestion, absorption barriers, specific physiological periods, or artificial diet controls driven by profit. Nutritional and metabolic diseases that cause harm and loss are second only to epidemic infectious diseases; therefore, more and more studies have focused on this topic in recent years. Metabolites are intermediates or end products of metabolism, which can have a multitude of functions, such as energy conversion, signaling transduction, epigenetic influence, cofactor activity, interaction, defense, etc. Metabolites can be used not only as biomarkers for diagnosing and preventing metabolic diseases and precise nutrition requirements but also to analyze nutritional metabolic processes and homeostasis, stress responses, immune reactions, etc.

This Special Issue of Metabolites, “Nutritional and Metabolic Diseases in Animals”, is dedicated to dealing with the digestion, absorption, transport, and metabolism of carbohydrates, amino acids, lipids, vitamins, minerals, organic acids, alkaloids, and drugs as well as metabolomics, lipidomics, and the crosstalk between gastrointestinal microbiota and the host involved in nutritional and metabolic diseases in animals. This issue is not only intended for results about nutritional and metabolic diseases in domestic animals and in vitro models but is also open to results from cell and animal models for human nutritional and metabolic diseases.

Dr. Yanfeng Xue
Dr. Xiliang Du
Dr. Lizhuang Hao
Dr. Chenxu Zhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrient transport and metabolism
  • gastrointestinal microbiota
  • metabolomics
  • metabolic diseases
  • animal models and in vitro models

Published Papers (2 papers)

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Research

10 pages, 293 KiB  
Article
Analysis of the Differences in Muscle Nutrition among Individuals of Different Sexes in Redclaw Crayfish, Cherax quadricarinatus
by Yuyan Sun, Xin Shan, Desheng Li, Xuxiao Liu, Zongao Han, Junjie Qin, Bin Guan, Leilei Tan, Jianbo Zheng, Min Wei and Yongyi Jia
Metabolites 2023, 13(2), 190; https://doi.org/10.3390/metabo13020190 - 28 Jan 2023
Cited by 5 | Viewed by 1309
Abstract
Redclaw crayfish (Cherax quadricarinatus) was introduced to China many years ago. In recent years, a breeding boom for C. quadricarinatus has been set off in China due to a breakthrough in key technology of seedling breeding. The size and growth rate [...] Read more.
Redclaw crayfish (Cherax quadricarinatus) was introduced to China many years ago. In recent years, a breeding boom for C. quadricarinatus has been set off in China due to a breakthrough in key technology of seedling breeding. The size and growth rate of C. quadricarinatus vary greatly between female and male individuals, usually the size and growth rate of male individuals are bigger than that of female individuals. There is usually a certain linkage relationship between the sex traits of crustaceans and their own nutrition. In order to explore the linkage relationship between the sex traits of C. quadricarinatus and its nutritional components, this study measured and analyzed the muscle nutritional components of female and male individuals. The results showed that the meat yield rate of male individuals was significantly higher than that of females (p < 0.05), and the crude fat content was significantly lower than that for females (p < 0.05). The ratios of essential amino acids to total amino acids for females and males were 39.61% and 38.49%, respectively. The ratios of essential amino acids to non-essential amino acids were 79.69% and 75.66%, respectively, which far exceed FAO/WHO standards and both belong to high-quality protein. The total amount of flavor amino acids of male individuals was significantly higher than that of female individuals (p < 0.05). The total amount of polyunsaturated fatty acids and the polyunsaturated fatty acid eicosapentaenoic acid of males are both significantly higher than that of females (p < 0.05). Studies have shown that there are certain differences in nutrition between male and female individuals. Compared with female individuals, the meat yield rate, crude protein content, and edible value of the muscles of male individuals is higher. Full article
(This article belongs to the Special Issue Nutritional and Metabolic Diseases in Animals)
18 pages, 3783 KiB  
Article
Mammary Fibrosis Tendency and Mitochondrial Adaptability in Dairy Cows with Mastitis
by Xingchi Kan, Guiqiu Hu, Yiyao Liu, Ping Xu, Yaping Huang, Xiangyu Cai, Wenjin Guo, Shoupeng Fu and Juxiong Liu
Metabolites 2022, 12(11), 1035; https://doi.org/10.3390/metabo12111035 - 28 Oct 2022
Cited by 3 | Viewed by 1495
Abstract
Dairy cow mammary gland fibrosis causes huge economic losses to livestock production, however, research on dairy cow mammary gland fibrosis is in its infancy and it lacks effective treatments. Therefore, the purpose of this experiment was to explore the correlation between mastitis and [...] Read more.
Dairy cow mammary gland fibrosis causes huge economic losses to livestock production, however, research on dairy cow mammary gland fibrosis is in its infancy and it lacks effective treatments. Therefore, the purpose of this experiment was to explore the correlation between mastitis and fibrosis and mitochondrial damage, and to further explore its pathogenesis. In vivo, mammary tissue and milk samples were collected from healthy cows (n = 10) and mastitis cows (n = 10). The results of the study showed that compared with the control group, the mastitis tissue showed tissue damage, accumulation of collagen fibers, and the content of TGF-β1 in mammary tissue and milk was significantly increased; the level of inflammatory mediators was significantly increased; the fibrotic phenotype, collagen 1, α-SMA, vimentin gene, and protein levels were significantly increased, while the E-cadherin gene and protein levels were significantly decreased. In vitro, based on TGF-β1-induced bMECs, the above experimental results were further confirmed, and TGF-β1 significantly promoted the fibrotic phenotype of bMECs. On the other hand, in vivo results showed that fibrotic mammary tissue had a significantly stronger mitochondrial damage phenotype and significantly higher ROS than the control group. In vitro, the results also found that TGF-β1 induced a significant increase in the mitochondrial damage phenotype of bMECs, accompanied by a large amount of ROS production. Furthermore, in a TGF-β1-induced bMEC model, inhibiting the accumulation of ROS effectively alleviated the elevated fibrotic phenotype of TGF-β1-induced bMECs. In conclusion, the fibrotic phenotype of mammary gland tissue in dairy cows with mastitis was significantly increased, and mastitis disease was positively correlated with mammary fibrotic lesions. In an in vitro and in vivo model of cow mammary fibrosis, bMECs have impaired mitochondrial structure and dysfunction. Inhibiting the accumulation of ROS effectively alleviates the elevated fibrotic phenotype, which may be a potential therapeutic approach to alleviate mammary fibrosis. Full article
(This article belongs to the Special Issue Nutritional and Metabolic Diseases in Animals)
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