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Metabolites
Special Issues
Plant Metabolites for Managing Chemotherapy-Induced Side Effects
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Plant Metabolites for Managing Chemotherapy-Induced Side Effects

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: 25 July 2026 | Viewed by 387

Special Issue Editor

Dr. Woojin Kim

E-Mail Website
Guest Editor
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea
Interests: chemotherapy-induced side effects; neuropathic pain; anorexia; bee venom; herbal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a result of the increasing number of patients suffering from cancer, side effects caused by chemotherapy treatments have become major complications in cancer therapies. Chemotherapy-induced side effects (CISEs) are major problems, as they can lead to the lowering of the dose and even to the discontinuation of the treatment. However, no optimal drug exists that could effectively decrease these side effects, as currently prescribed medicines may also have their side effects. Thus, it is important to find an effective drug that could attenuate CISEs without interrupting the action of the chemotherapeutic drug.

The goal of this Special Issue is first to help understand the pathophysiological mechanisms of various CISEs and second to find novel drugs derived from plants that could be effective in attenuating CISEs. Although chemotherapeutic agents are known to mostly affect the peripheral parts, it is also known that they could affect different parts of the central nervous system. Thus, studies focused on the changes in peripheral and central neuron systems and research that could clarify the action of various drugs, including plant extracts and their secondary metabolites, will also fit within the scope of our topic. This Special Issue aims to cover promising, recent, and novel research that could help in understanding the underlying mechanisms of CISEs and help develop novel drugs.

We welcome original research, reviews, mini reviews, and perspective articles on themes including, but not limited to, the following:

  • The pathophysiological mechanisms of CISEs;
  • The prevention and treatment of CISEs;
  • The roles of plant extracts and secondary metabolites in preventing and treating CISEs.

Dr. Woojin Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemotherapy-induced side effects
  • pain
  • nausea and vomiting
  • neutropenia

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Published Papers (1 paper)

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Research

20 pages, 3007 KB  
Article
Plant-Derived Secondary Metabolites Tetrahydropalmatine and Rutaecarpine Alleviate Paclitaxel-Induced Neuropathic Pain via TRPV1 and TRPM8 Modulation
by Keun-Tae Park, Hyesang Yun, Juyeol Kang, Jae-Chul Lee and Woojin Kim
Metabolites 2026, 16(1), 46; https://doi.org/10.3390/metabo16010046 - 4 Jan 2026
Viewed by 257
Abstract
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting adverse effect of paclitaxel and is characterized by cold and mechanical allodynia. Effective therapeutic strategies for CIPN remain limited. This study evaluated the analgesic potential of Corydalis yanhusuo (CY) and Evodia rutaecarpa (ER), as [...] Read more.
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting adverse effect of paclitaxel and is characterized by cold and mechanical allodynia. Effective therapeutic strategies for CIPN remain limited. This study evaluated the analgesic potential of Corydalis yanhusuo (CY) and Evodia rutaecarpa (ER), as well as their major alkaloids tetrahydropalmatine (THP) and rutaecarpine, in a mouse model of paclitaxel-induced neuropathic pain. Methods: Neuropathic pain was induced by paclitaxel administration (2 mg/kg, i.p., four injections). CY and ER extracts were orally administered at doses of 100 or 300 mg/kg, either alone or in combination, and cold and mechanical allodynia were assessed from days 0 to 8. The analgesic effects of THP and rutaecarpine were also examined. Gene and protein expression analyses were performed to evaluate the involvement of TRPV1 and TRPM8 signaling pathways, and high-performance liquid chromatography (HPLC) was used to confirm the presence of THP in CY and rutaecarpine in ER. Results: Paclitaxel reliably induced robust cold and mechanical hypersensitivity. Oral administration of CY or ER significantly alleviated allodynia in a dose-dependent manner, with greater efficacy at 300 mg/kg. Combined CY–ER treatment produced stronger anti-allodynic effects than either extract alone. THP and rutaecarpine also exhibited dose-dependent analgesic effects, and their co-administration yielded the most pronounced inhibition of paclitaxel-evoked hypersensitivity. Molecular analyses confirmed the involvement of TRPV1- and TRPM8-related pathways in these analgesic effects. Collectively, these findings indicate that CY, ER, and their representative alkaloids effectively attenuate paclitaxel-induced neuropathic pain and highlight CY–ER-based natural products as promising candidates for managing CIPN through modulation of TRPV1/TRPM8 signaling. Full article
(This article belongs to the Special Issue Plant Metabolites for Managing Chemotherapy-Induced Side Effects)
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