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Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced...
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Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Plant Metabolism".

Deadline for manuscript submissions: closed (20 September 2025) | Viewed by 843

Special Issue Editor

Prof. Dr. Woojin Kim

E-Mail Website
Guest Editor
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul 02453, Republic of Korea
Interests: chemotherapy-induced side effects; neuropathic pain; anorexia; bee venom; herbal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Owing to the increasing number of patients suffering from cancer, side effects caused by chemotherapy treatments have become major complications in cancer therapies. Chemotherapy-induced side effects (CISEs) are major problems as they can lead to the lowering of the dose and even to the discontinuation of the treatment. However, no optimal drug exists that could effectively decrease these side effects, as currently prescribed medicines may also have their side effects. Thus, it is important to find an effective drug that could attenuate CISEs without interrupting the action of the chemotherapeutic drug.

The goal of this Special Issue is first to help understand the pathophysiological mechanisms of various CISEs, and second to find novel drugs derived from plants that could be effective in attenuating CISEs. Although chemotherapeutic agents are known to mostly affect the peripheral parts, it is also known that they could affect different parts of the central nervous system. Thus, studies focused on the changes in peripheral and central neuron systems and research that could clarify the action of various drugs including plant extracts and their secondary metabolites will also fit within the scope of our topic. This Special Issue aims to cover promising, recent, and novel research that could help in understanding the underlying mechanisms of CISEs and help develop novel drugs.

We welcome Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to, the following:

  • The pathophysiological mechanisms of CISEs;
  • The prevention and treatment of CISEs;
  • The roles of plant extracts and secondary metabolites in preventing and treating CISEs.

Prof. Dr. Woojin Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemotherapy-induced side effects
  • pain
  • nausea and vomiting
  • neutropenia

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Published Papers (1 paper)

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Research

16 pages, 1094 KB  
Article
A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model
by Michael Daniel, Stacie Totsch, Peng Li, Chisom O. Odii, Heather Shelton, Robert E. Sorge and Ellen Mary Lavoie Smith
Metabolites 2025, 15(10), 680; https://doi.org/10.3390/metabo15100680 - 21 Oct 2025
Viewed by 358
Abstract
Background/Objectives: The purpose of this preclinical pilot study was to explore the potential of green tea extract (GTE) to mitigate and/or prevent oxaliplatin-induced allodynia and axonal damage in rats, when compared to duloxetine (DLX), an ASCO-recommended treatment for established neuropathic pain. Methods: Using [...] Read more.
Background/Objectives: The purpose of this preclinical pilot study was to explore the potential of green tea extract (GTE) to mitigate and/or prevent oxaliplatin-induced allodynia and axonal damage in rats, when compared to duloxetine (DLX), an ASCO-recommended treatment for established neuropathic pain. Methods: Using a randomized, placebo-controlled experimental design, Sprague Dawley rats (N = 41) received 4 intraperitoneal oxaliplatin (2 mg/kg) injections every other day over 7 days. One week prior to the first oxaliplatin dose, animals began 1 of 4 interventions (saline; GTE 100 mg/kg; DLX 3 mg/kg; GTE 100 mg/kg + DLX 3 mg/kg). A naïve group (n = 6) that received no neurotoxic oxaliplatin or intervention was added to serve as a baseline measure for sNfL. Interventions were administered daily for 4 weeks. Mechanical sensitivity (allodynia) was measured 3 times per week using von Frey testing to determine paw withdrawal thresholds. Von Frey testing began one day prior to the start of interventions to establish baselines and continued through Day 35. Groups were compared to their respective baselines to calculate changes in paw withdrawal thresholds. To measure axonal damage, alterations in serum levels of neurofilament light (sNfL) protein were measured at Day 35 using ELISA. Group differences were identified using two-way analysis of variance (ANOVA). Pearson correlation coefficient was used for correlation analysis between paw withdrawal thresholds and sNfL levels at Day 35. Partial eta-squared and Hedges’ g were used to measure effect sizes. Statistical significance was assigned at P ≤ 0.05 with a 95% confidence interval. Results: Overall, the saline group showed significant reductions in mean paw withdrawal thresholds across experimental timepoints, denoting more severe allodynia caused by oxaliplatin. Conversely, intervention groups exhibited mean paw withdrawal thresholds that were significantly greater than the saline group, indicating less allodynia. The average level of sNfL was also significantly higher in the saline group (113.58 ± 43.84 pg/mL) compared to GTE100 (72.75 ± 26.85), DLX3 (59.93 ± 20.57), and DLX3 + GTE100 (77.04 ± 24.35) intervention groups, suggesting less oxaliplatin-induced axonal damage in these groups. The naïve group exhibited the lowest levels of sNfL (45.69 ± 14.64) when compared to the oxaliplatin-receiving groups (saline and intervention). There were large effect sizes between the saline group, naïve (g = 1.88), GTE100 (g = 1.123), DLX3 (g = 1.157), and DLX3 + GTE100 (g = 1.030) groups. There was also a moderate negative correlation [r(30) = −0.38, p = 0.04] between sNfL levels and paw withdrawal thresholds. Conclusions: The preliminary findings from this pilot study suggest that GTE may be an effective, nutraceutical intervention for mitigating OIPN-associated neuropathic pain, warranting further investigation as an intervention to mitigate chemotherapy-associated neurotoxicities like OIPN. Full article
(This article belongs to the Special Issue Roles of Plant Secondary Metabolites in Preventing and Treating Chemotherapy-Induced Side Effects)
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