Special Issue "Amino Acid Metabolism in Health and Disease"
Deadline for manuscript submissions: closed (1 March 2022) | Viewed by 4623
Interests: flavoenzyme D-amino acid oxidase (DAAO); D-amino acids; metabolism; neuromodulators; enzyme; sitedirected mutagenesis; kinetic and protein stability studies; flavin reactivity and redox properties analyses
Amino acids are not only the building blocks of proteins; they also act as intermediate metabolites fueling different biosynthetic pathways, and some function as or are synthesized into important molecules such as neurotransmitters, hormones, pigments, and oxygen-carrying molecules. Thus, plasma and intracellular amino acid availability and homeostasis are crucial and require a coordinated metabolism of synthetic, catabolic, and transport pathways. Accordingly, amino acid-related metabolic disorders comprise a very heterogeneous group of diseases, whose severity may range from mild to highly disabling illness, brain damage, or multi-organ involvement.
In this Special Issue, we aim to provide new insights into amino acid metabolism in health and disease, with an in-depth look also at D-amino acids and their role in brain “functioning and dysfunctioning”. We hope that the addressed topic will lead to a better understanding of the diverse mechanisms acting in the regulation of amino acid metabolism as well as further research studies aimed at investigating metabolic dysfunctions and their role in pathologies.
Dr. Silvia Sacchi
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