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Review

Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential

by 1,2,3 and 1,3,*
1
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Nephrology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China
3
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Silvia Sacchi and Peter Meikle
Metabolites 2022, 12(1), 58; https://doi.org/10.3390/metabo12010058
Received: 6 December 2021 / Revised: 29 December 2021 / Accepted: 4 January 2022 / Published: 10 January 2022
(This article belongs to the Special Issue Amino Acid Metabolism in Health and Disease)
Ferroptosis is a newly identified form of regulated cell death driven by iron-dependent phospholipid peroxidation and oxidative stress. Ferroptosis has distinct biological and morphology characteristics, such as shrunken mitochondria when compared to other known regulated cell deaths. The regulation of ferroptosis includes different molecular mechanisms and multiple cellular metabolic pathways, including glutathione/glutathione peroxidase 4(GPX4) signaling pathways, which are involved in the amino acid metabolism and the activation of GPX4; iron metabolic signaling pathways, which are involved in the regulation of iron import/export and the storage/release of intracellular iron through iron-regulatory proteins (IRPs), and lipid metabolic signaling pathways, which are involved in the metabolism of unsaturated fatty acids in cell membranes. Ferroptosis plays an essential role in the pathology of various kidneys diseases, including acute kidney injury (AKI), chronic kidney disease (CKD), autosomal dominant polycystic kidney disease (ADPKD), and renal cell carcinoma (RCC). Targeting ferroptosis with its inducers/initiators and inhibitors can modulate the progression of kidney diseases in animal models. In this review, we discuss the characteristics of ferroptosis and the ferroptosis-based mechanisms, highlighting the potential role of the main ferroptosis-associated metabolic pathways in the treatment and prevention of various kidney diseases. View Full-Text
Keywords: abnormal metabolism; ferroptosis; kidney disease; therapeutic abnormal metabolism; ferroptosis; kidney disease; therapeutic
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MDPI and ACS Style

Zhang, X.; Li, X. Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential. Metabolites 2022, 12, 58. https://doi.org/10.3390/metabo12010058

AMA Style

Zhang X, Li X. Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential. Metabolites. 2022; 12(1):58. https://doi.org/10.3390/metabo12010058

Chicago/Turabian Style

Zhang, Xiaoqin, and Xiaogang Li. 2022. "Abnormal Iron and Lipid Metabolism Mediated Ferroptosis in Kidney Diseases and Its Therapeutic Potential" Metabolites 12, no. 1: 58. https://doi.org/10.3390/metabo12010058

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