Nutritional Metabolomics in Cancer

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (5 May 2025) | Viewed by 1516

Special Issue Editors


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Guest Editor
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Interests: cancer; tumor microenvironment; metabolism; lipid; nutrients

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Guest Editor
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Interests: immunology; anti-tumor immunity; cancer immunotherapy; metabolism; nutritional science

Special Issue Information

Dear Colleagues,

This Special Issue on “Nutritional Metabolomics in Cancer” in the journal Metabolites explores the intricate relationship between nutrition and cancer through a metabolomic approach. As our understanding of cancer biology advances, it becomes increasingly evident that diet and nutrition play pivotal roles in cancer development, progression, and therapy. This Special Issue complies cutting-edge research that utilizes metabolomics to reveal how dietary components influence cancer metabolism, identify metabolic biomarkers for cancer prognosis and treatment response, and elucidate metabolic pathways affected by nutritional interventions. We encourage submissions investigating metabolic alterations induced by specific diets, nutrients, or bioactive food compounds, and their implications in cancer biology. Studies exploring the interaction between nutritional status and cancer treatment efficacy, as well as those identifying metabolic signatures predictive of cancer outcomes, are particularly welcome. The scope includes mechanistic studies on dietary metabolites in cancer cell metabolism, the identification and validation of metabolomic biomarkers for early detection, prognosis, and therapeutic monitoring, and interventional studies examining the effects of specific diets or nutritional compounds on cancer metabolism. By highlighting innovative research, we aim to pave the way for integrating nutritional strategies into cancer prevention and treatment, ultimately contributing to personalized nutritional interventions that enhance cancer care. We invite researchers and clinicians to submit original research articles, reviews, and case studies aligning with the themes of this Special Issue.

Dr. Hayato Muranaka
Dr. Suguru Saito
Guest Editors

Manuscript Submission Information

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Keywords

  • nutritional metabolomics
  • cancer metabolism
  • nutritional interventions
  • metabolomics in cancer therapy
  • cancer biomarkers

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Published Papers (1 paper)

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Research

13 pages, 5185 KiB  
Article
A Comprehensive Metabolomic and Microbial Analysis Following Dietary Amino Acid Reduction in Mice
by Raghad Khalid Al-Ishaq, Carmen R. Ferrara, Nisha Stephan, Jan Krumsiek, Karsten Suhre and David C. Montrose
Metabolites 2024, 14(12), 706; https://doi.org/10.3390/metabo14120706 - 14 Dec 2024
Viewed by 1168
Abstract
Introduction: Nutritional metabolomics provides a comprehensive overview of the biochemical processes that are induced by dietary intake through the measurement of metabolite profiles in biological samples. However, there is a lack of deep phenotypic analysis that shows how dietary interventions influence the metabolic [...] Read more.
Introduction: Nutritional metabolomics provides a comprehensive overview of the biochemical processes that are induced by dietary intake through the measurement of metabolite profiles in biological samples. However, there is a lack of deep phenotypic analysis that shows how dietary interventions influence the metabolic state across multiple physiologic sites. Dietary amino acids have emerged as important nutrients for physiology and pathophysiology given their ability to impact cell metabolism. Methods: The aim of the current study is to evaluate the effect of modulating amino acids in diet on the metabolome and microbiome of mice. Here, we report a comprehensive metabolite profiling across serum, liver, and feces, in addition to gut microbial analyses, following a reduction in either total dietary protein or diet-derived non-essential amino acids in mice. Results: We observed both distinct and overlapping patterns in the metabolic profile changes across the three sample types, with the strongest signals observed in liver and serum. Although amino acids and related molecules were the most commonly and strongly altered group of metabolites, additional small molecule changes included those related to glycolysis and the tricarboxylic acid cycle. Microbial profiling of feces showed significant differences in the abundance of select species across groups of mice. Conclusions: Our results demonstrate how changes in dietary amino acids influence the metabolic profiles across organ systems and the utility of metabolomic profiling for assessing diet-induced alterations in metabolism. Full article
(This article belongs to the Special Issue Nutritional Metabolomics in Cancer)
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