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Metabolites
Special Issues
Metabolomics of the Eye and Adnexa
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Metabolomics of the Eye and Adnexa

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2443

Special Issue Editors

Dr. Seher Yuksel

E-Mail Website
Guest Editor
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9057, USA
Interests: meibomian gland dysfunction; dry eye; lipidomics; mass spectrometry
Dr. Igor A. Butovich

E-Mail Website
Guest Editor
Department of Ophthalmology, and the Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9057, USA
Interests: meibomian gland dysfunction; dry eye; lipidomics; mass spectrometry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are excited to announce this upcoming Special Issue of Metabolites, titled “Metabolomics of the Eye and Adnexa”. Metabolomics is a field of science that uses numerous approaches to identify changes in metabolite profiles and levels to establish and explore associations between them and various ocular pathologies, such as dry eye, glaucoma, keratoconus, or age-related macular degeneration. Identifying biomarkers using metabolomic approaches that indicate the early stages of ocular diseases will result in the earlier diagnosis and treatment of these ocular diseases. Understanding the complex relationship between metabolism and ocular diseases is critical in developing novel therapeutic remedies to slow down or reverse the course of these life-altering disorders, which can lead to blindness. This Special Issue will delve into the intricate metabolic changes in ocular diseases. We warmly welcome submissions of both basic science and clinical reports, promoting a comprehensive exploration of this critical subject. Moreover, we aim to present cutting-edge reviews and original articles exploring the onset and progression of metabolic disorders potentially involving the eye and adnexa.

Dr. Seher Yuksel
Dr. Igor Butovich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • metabolites
  • ocular disease
  • Meibomian gland dysfunction
  • age-related macular de-generation
  • glaucoma
  • diabetic retinopathy
  • keratoconus
  • gas chromatography/liquid chromatog-raphy-mass spectrometry
  • nuclear magnetic resonance spectroscopy

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Published Papers (2 papers)

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Research

11 pages, 441 KiB  
Article
Plasma and Urine Metabolites Associated with Microperimetric Retinal Sensitivity in Age-Related Macular Degeneration
by Krupa Sourirajan, Kevin Mendez, Ines Lains, Gregory Tsougranis, Haemin Kang, Georgiy Kozak, Augustine Bannerman, Roshni Bhat, Hanna Choi, Archana Nigalye, Ivana K. Kim, Demetrios G. Vavvas, David M. Wu, Liming Liang, John B. Miller, Joan W. Miller, Jessica Lasky-Su and Deeba Husain
Metabolites 2025, 15(4), 232; https://doi.org/10.3390/metabo15040232 - 28 Mar 2025
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Abstract
Background: Best-corrected visual acuity (BCVA) is the current gold standard of retinal function measurement but is not affected in early and intermediate forms of age-related macular degeneration (AMD). Increasing evidence suggests that microperimetry is a sensitive measure of visual function. This study sought [...] Read more.
Background: Best-corrected visual acuity (BCVA) is the current gold standard of retinal function measurement but is not affected in early and intermediate forms of age-related macular degeneration (AMD). Increasing evidence suggests that microperimetry is a sensitive measure of visual function. This study sought to analyze the associations between plasma and urine metabolites and microperimetry in AMD. Methods: We included data on 363 eyes (95 controls, 268 AMD). Microperimetry was performed in patients with or without AMD using the Macular Integrity Assessment (MAIA) microperimetry system, employing a 37-point full-threshold protocol. Plasma and urine samples were analyzed via ultra-high-performance liquid chromatography–mass spectrometry. Multilevel mixed-effects linear models were used to assess associations between the metabolites and retinal sensitivity. Statistical significance was determined by considering the number of independent tests that accounted for 80% of the variance (ENT80). Results: We identified two plasma and seven urine metabolites, which were significantly associated with mean retinal sensitivity in AMD, and the key results include metabolites in the lysine metabolism pathway. Conclusions: To our knowledge, we present the first assessment of the associations between plasma and urinary metabolites and retinal microperimetry sensitivity in AMD. This work can reveal more insight into the pathogenesis of AMD. Full article
(This article belongs to the Special Issue Metabolomics of the Eye and Adnexa)
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17 pages, 4027 KiB  
Article
Type 1 Diabetes and Cataracts: Investigating Mediating Effects of Serum Metabolites Using Bidirectional Mendelian Randomization
by Yumeng Shi, Jingxi Qin, Yankai Li, Jin Yang and Yi Lu
Metabolites 2024, 14(11), 644; https://doi.org/10.3390/metabo14110644 - 20 Nov 2024
Viewed by 1347
Abstract
Purpose: To investigate the causal relationship between type 1 diabetes (T1D) and cataracts and to explore the mediating role of serum metabolites. Methods: This study employed bidirectional Mendelian randomization (MR) using genetic variants as instrumental variables to infer causality in both directions: from [...] Read more.
Purpose: To investigate the causal relationship between type 1 diabetes (T1D) and cataracts and to explore the mediating role of serum metabolites. Methods: This study employed bidirectional Mendelian randomization (MR) using genetic variants as instrumental variables to infer causality in both directions: from T1D to cataracts and cataracts to T1D. Genetic data for T1D, its complications, and cataracts were sourced from independent genome-wide association study (GWAS) datasets. A two-step multivariable MR combined with mediation analysis was conducted to evaluate the indirect effects of serum metabolites in the causal pathway from T1D to cataracts. Results: The MR analysis demonstrated a significant causal association between T1D and an increased risk of cataracts (OR = 1.01–1.05; p < 0.05). Further analysis showed that patients with T1D complications such as coma, ketoacidosis, nephropathy, and retinopathy exhibited a significantly higher risk of developing cataracts compared to those without complications. Sensitivity analyses upheld the robustness of these findings, with no evidence of heterogeneity or pleiotropy. Additionally, 102 serum metabolites were found to exhibit statistically significant mediation effects on cataract risk, with four (13-HODE + 9-HODE, 2-naphthol sulfate, docosadienoate (22:2n6), and X-12906) showing significant mediation effects. Specifically, 13-HODE + 9-HODE had a protective effect, while the other three metabolites were linked to an increased cataract risk. Conclusions: This study provides strong evidence of a causal link between T1D and cataracts, highlighting the mediating role of specific serum metabolites. These findings underscore the importance of early detection and management of cataracts in patients with T1D and suggest potential therapeutic targets for mitigating cataract risk. Further research should focus on replicating these findings in diverse populations and exploring the underlying metabolic pathways in greater detail. Full article
(This article belongs to the Special Issue Metabolomics of the Eye and Adnexa)
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