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Special Issue Editors

Dr. Maria Aderuza Horst

E-Mail Website
Guest Editor

Nutritional Genomics Research Group, Faculty of Nutrition, Federal University of Goiás (UFG), Goiânia 74690-900, Brazil
Interests: precision nutrition; nutritional genomics; nutrigenetics; cancer

Dr. Lucas Carminatti Pantaleão

E-Mail Website
Guest Editor

Institute of Metabolic Science, University of Cambridge, Cambridge, UK
Interests: developmental programming; maternal obesity; miRNAs; lipids

Special Issue Information

Dear Colleagues,

Current research has highlighted that organ and systemic damage associated with metabolic diseases might be the result of a complex network of interactions between genetics and the environment, potentially orchestrated by epigenetic mechanisms. Cells exhibit three major interconnected epigenetic systems that can turn genes on or off: (a) DNA methylation, (b) post-transcriptional histone modifications, and (c) non-coding RNAs (including microRNAs). A deeper understanding of the diet’s influence on epigenetic modifications may therefore contribute to the comprehension of disease pathogenesis, to the development of novel treatments, and to the identification of individuals at risk of metabolic disease. This Special Issue of Metabolites is dedicated to publishing state-of-the-art research on nutritional epigenomics. We welcome authors involved in the analysis of epigenetic modifications leading to or preventing metabolic diseases. We welcome the submission of articles covering, but not limited to, the following topics:

Epigenetic applications for precision nutrition;
Protocols for clinical trials for the investigation of epigenetic modifications in response to nutrients;
Studies aiming to investigate the role of specific epigenetic modifications in experimental models;
Observational studies on epigenetic changes in humans affected by diet-related diseases;
Studies on the correlation between epigenetic modifications and exposome (e.g., gut microbiome);
Systematic or comprehensive reviews about any epigenetic question related to nutrition;
Epigenetic processes with food and other bioactive compounds;
Epigenetic modifications as clinical biomarkers for metabolic diseases;
Epigenetics and dietary habits or specific nutrients during prenatal and postnatal life;
Studies focusing on candidate metabolites and metabolic pathways.

Dr. Maria Aderuza Horst
Dr. Lucas Carminatti Pantaleão
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

precision nutrition
epigenetic modifications
programming
nutrients
nutritional epigenetics

Published Papers (2 papers)

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Research

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14 pages, 1761 KiB

Open AccessArticle

Circulating microRNAs Showed Specific Responses according to Metabolic Syndrome Components and Sex of Adults from a Population-Based Study

by Paula N. Brandão-Lima, Gabrielli B. de Carvalho, Tanyara B. Payolla, Flávia M. Sarti, Regina M. Fisberg, Fiona C. Malcomson, John C. Mathers and Marcelo M. Rogero

Metabolites 2023, 13(1), 2; https://doi.org/10.3390/metabo13010002 - 20 Dec 2022

Cited by 6 | Viewed by 1765

Abstract

MicroRNAs (miRNAs) regulate several metabolic pathways and are potential biomarkers for early risk prediction of metabolic syndrome (MetS). Our aim was to evaluate the levels of 21 miRNAs in plasma according to MetS components and sex in adults. We employed a cross-sectional study of 192 adults aged 20 to 59 years old from the 2015 Health Survey of São Paulo with Focus in Nutrition. Data showed reduced levels of miR-16 and miR-363 in women with MetS; however, men with one or more risk factors showed higher levels of miR-let-7c and miR-30a. Individuals with raised waist circumference showed higher levels of miR-let-7c, miR-122, miR-30a, miR-146a, miR-15a, miR-30d and miR-222. Individuals with raised blood pressure had higher miR-30a, miR-122 and miR-30a levels. Plasma levels of four miRNAs (miR-16, miR-363, miR-375 and miR-486) were lower in individuals with low HDL-cholesterol concentrations. In addition, plasma levels of five miRNAs (miR-122, miR-139, miR-let-7c, miR-126 and miR-30a) were increased in individuals with high fasting plasma glucose and/or insulin resistance. Our results suggest that the pattern of miRNA levels in plasma may be a useful early biomarker of cardiometabolic components of MetS and highlight the sex differences in the plasma levels of miRNAs in individuals with MetS. Full article

(This article belongs to the Special Issue Role of Diet-Induced Epigenetic Modifications on Promoting or Preventing Metabolic Diseases)

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22 pages, 1282 KiB

Open AccessSystematic Review

Circulating microRNA Related to Cardiometabolic Risk Factors for Metabolic Syndrome: A Systematic Review

by Paula N. Brandão-Lima, Gabrielli B. de Carvalho, Tanyara B. Payolla, Flavia M. Sarti and Marcelo M. Rogero

Metabolites 2022, 12(11), 1044; https://doi.org/10.3390/metabo12111044 - 30 Oct 2022

Cited by 4 | Viewed by 1518

Abstract

MicroRNA regulates multiple pathways in inflammatory response, adipogenesis, and glucose and lipid metabolism, which are involved in metabolic syndrome (MetS). Thus, this systematic review aimed at synthesizing the evidence on the relationships between circulating microRNA and risk factors for MetS. The systematic review was registered in the PROSPERO database (CRD42020168100) and included 24 case-control studies evaluating microRNA expression in serum/plasma of individuals ≥5 years old. Most of the studies focused on 13 microRNAs with higher frequency and there were robust connections between miR-146a and miR-122 with risk factors for MetS, based on average weighted degree. In addition, there was an association of miR-222 with adiposity, lipid metabolism, glycemic metabolism, and chronic inflammation and an association of miR-126, miR-221, and miR-423 with adiposity, lipid, and glycemic metabolism. A major part of circulating microRNA was upregulated in individuals with risk factors for MetS, showing correlations with glycemic and lipid markers and body adiposity. Circulating microRNA showed distinct expression profiles according to the clinical condition of individuals, being particularly linked with increased body fat. However, the exploration of factors associated with variations in microRNA expression was limited by the variety of microRNAs investigated by risk factor in diverse studies identified in this systematic review. Full article

(This article belongs to the Special Issue Role of Diet-Induced Epigenetic Modifications on Promoting or Preventing Metabolic Diseases)

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