Environmental Factors Affecting Fish Metabolism

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1453

Special Issue Editors

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Guest Editor
Blue Biotechnology and Ecotoxicology CIIMAR - Interdisciplinary Centre of Marine and Environmental Research, Matosinhos, Portugal
Interests: ecotoxicology; fish metabolism; aquatic contamination; molecular biology (omics); alternative model species

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Guest Editor
Applied Ecology and Ecotoxicology R&D Group, Department of Biology & CESAM, University of Aveiro Campus, Universitário de Santiago, 3810-193 Aveiro, Portugal
Interests: nanotoxicity; emerging contaminants; biomarkers; behaviour; alternative methods

Special Issue Information

Dear Colleagues,

Through their life cycle, fish can be exposed to a range of stressors as a result of anthropogenic activities. There is, therefore, the need to study the effects induced by alterations to the natural environment, including lesser known and emergent contaminants such as nanoparticles, pharmaceuticals, recreational drugs or biotoxins, and other classes of contaminants, as well as alterations in abiotic parameters (e.g., ultraviolet radiation, temperature, ocean acidification). Such stressors may induce undesired developmental/metabolic effects to fish immediately after exposure. Some contaminants may also bioaccumulate in different organs and cause delayed effects. Stressors may also affect fish organ functioning in different ways. For instance, they may affect the liver, one of the most important organs for the detoxification and storage of exogenous substances, while playing a key role in fish metabolism and growth. Information related to molecular mechanisms involved in the effects induced by single and combined stressors is also lacking. The route of exposure (e.g., diet, sediment, or water-borne) contaminants may lead to distinct effects to fish, and thus, it is also important to study them.

Thus, this Special Issue is particularly dedicated to unveiling molecular processes and physiological implications of emerging contaminants and abiotic stressors affecting fish in natural environments.

The Guest Editors welcome and encourage authors to submit their works, including original research articles as well as mini and full reviews and perspectives. Research studies should include OMICs, such as metabolomics, proteomics, genomics, or transcriptomics.

Topics covered by the Special Issue include, but are not limited to:

  • Functional biological alterations induced by emerging contaminants and other stressors in fish.
  • Mechanisms and AOP of emerging contaminants.
  • Integration of effects of stressors at biochemical, cellular, and individual levels.
  • Alternative models and new “in vitro” procedures in aquatic toxicology.
  • New molecular tools for aquatic toxicology.

Dr. Mário Araújo
Dr. Alexandre M. Campos
Dr. Miguel Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bioaccumulation
  • biotoxins
  • drugs and metabolites
  • molecular biology
  • nanocontaminants
  • oxidative stress
  • physiological condition
  • OMICs

Published Papers (1 paper)

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9 pages, 672 KiB  
Protein Synthesis Determined from Non-Radioactive Phenylalanine Incorporated by Antarctic Fish
by Nina Krebs, Jan Tebben, Christian Bock, Felix C. Mark, Magnus Lucassen, Gisela Lannig and Hans-Otto Pörtner
Metabolites 2023, 13(3), 338; https://doi.org/10.3390/metabo13030338 - 24 Feb 2023
Cited by 1 | Viewed by 991
Direct measurements of temperature-dependent weight gains are experimentally challenging and time-consuming in long-lived/slow-growing organisms such as Antarctic fish. Here, we reassess methodology to quantify the in vivo protein synthesis rate from amino acids, as a key component of growth. We tested whether it [...] Read more.
Direct measurements of temperature-dependent weight gains are experimentally challenging and time-consuming in long-lived/slow-growing organisms such as Antarctic fish. Here, we reassess methodology to quantify the in vivo protein synthesis rate from amino acids, as a key component of growth. We tested whether it is possible to avoid hazardous radioactive materials and whether the analytical pathway chosen is robust against analytical errors. In the eelpout, Pachycara brachycephalum, 13C9H1115N1O2 phenylalanine was injected intraperitoneally and muscle tissue was sampled before injection and at 1.5 h time intervals up to 6 h thereafter. The incorporation of 13C15N-labeled-phenylalanine into muscle was monitored by quantification of bound and free phenylalanine through liquid chromatography–mass spectrometry. We found an increase in the pool of labeled, free phenylalanine in the cytosolic fraction that leveled off after 4.5 h. The labeled phenylalanine bound in the proteins increased linearly over time. The resulting protein synthesis rate (Ks) for P. brachycephalum was as low as 0.049 ± 0.021% day−1. This value and its variability were in good agreement with literature data obtained from studies using radioactive labels, indicating that this methodology is well suited for characterizing growth in polar fish under in situ conditions in remote areas or on research vessels. Full article
(This article belongs to the Special Issue Environmental Factors Affecting Fish Metabolism)
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