Special Issue "Biomolecules in Cell Membranes: Structure and Dynamics"
Deadline for manuscript submissions: 15 November 2020.
Interests: Dr. Igor Zhukov is a specialist in multidimensional NMR spectroscopy. His research projects focused on structural analysis of biomolecules in solutions or lipids. He provides long-standing studies regarding the structural and dynamical aspects of neurodegenerative diseases, including Alzheimer disease and Transmissible Spongiform Encephalopathies. Other important points of his research are application of the multidimensional NMR techniques to structure evaluation and investigation of molecular dynamic processes in the transmembrane peptides and proteins in different lipid environments. In the studies, he uses the unique potential of the NMR spectroscopy to explore the molecular dynamic processes in proteins. The 15N relaxation data extracted from NMR experiments conducted on several magnetic fields constitute important information about dynamic processes, which make possible to shed light on structure – function relationship.
Keywords: NMR spectroscopy; structural analysis; NMR relaxation; structure-function relationship
Interests: cheminformatics; protein structure prediction; QSAR modelling; drug design
Membrane proteins constitute 30% of all proteins encoded in the human genome. Transmembrane proteins that span the entirety of the cell membrane provide key means of molecular transport through the cell membrane either out of or into the cell and cellular compartments. They control important cellular processes, such as signal transduction, uptake of metabolites, and energy conversion, and constitute a good target for developing new drugs for the pharmacology industry. However, the structure and stability of membrane proteins depend on the lipid environment, which is a limiting factor in the three-dimensional (3D) structural evaluation or analysis of molecular dynamic processes. Thus, the membrane proteins and peptides remain less characterized as compared to the soluble proteins. Taking into account the difficulties related to X-ray crystallography, NMR spectroscopy delivers critical information tha can shed light on physiological processes controlled by membrane proteins and peptides. Consequently, recent years have seen significant progress in the application of NMR spectroscopy supported by other methods to resolve functional and dynamical aspects of the regulation mechanisms of various functional cellular processes of membrane biomolecules.
The aim of this Special Issue is to demonstrate the newest achievements of NMR spectroscopy and other techniques applied to the membrane proteins, peptides, and small molecules positioned in a sophisticated lipid environment. We intend for this Special Issue to include structural evaluation, analysis of dynamic molecular processes, diffusion spectroscopy, and molecular dynamics simulations. Experimental studies might be supplemented with in silico modeling based on available big data sets, aiming at a structure-revealing data fusion. The submission of original as well as review articles on the above themes is most welcome.
Dr. Igor Zhukov
Prof. Marjana Novic
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Membranes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- NMR spectroscopy
- Membrane proteins
- 3D structure evaluation
- Membrane peptides
- NMR relaxation measurements
- Dynamic molecular processes
- Diffusion spectroscopy
- Structure modeling
- Molecular dynamics simulation