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Medicina
Special Issues
Liver Surgery: Current Treatment and Future Options
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Liver Surgery: Current Treatment and Future Options

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 25 June 2026 | Viewed by 2265

Special Issue Editor

Dr. Suk-Won Suh

E-Mail Website
Guest Editor
Department of Surgery, College of Medicine, Chung-Ang University, Seoul 156-755, Republic of Korea
Interests: hepatic resection; hepatocellular carcinoma; liver failure; circulating tumor cells; liver transplantation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Liver surgery includes hepatic resection and liver transplantation. Common indications for hepatic resection are hepatocellular carcinoma, liver metastasis from colon cancer, and bile duct origin intrahepatic tumors. Liver transplantation is the only curative treatment option for end-stage liver disease, and it is also an alternative treatment option for hepatocellular carcinoma. There have been many studies on novel challenges and advances in liver surgery, but the field still needs continuous effort and research.

The aim of this Special Issue is to introduce and discuss the current treatment and future options in liver surgery, including hepatic resection and liver transplantation. It includes the study of preoperative diagnosis, perioperative management, surgical techniques and innovations, and prognosis after surgery.

We invite colleagues around the world to share their experience and knowledge on novel challenges and advances in liver disease with original studies, reviews, or communications in order to develop this important field.

Dr. Suk-Won Suh
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver surgery
  • hepatic resection
  • liver transplantation
  • hepatocellular carcinoma
  • liver cirrhosis
  • liver failure
  • liver metastasis
  • cholangiocarcinoma

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Published Papers (1 paper)

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Research

12 pages, 285 KB  
Article
Benchmarking Donor Safety: Postoperative Complications and Risk Stratification in 502 Living Liver Donors
by Adem Tuncer, Emrah Sahin, Bulent Unal and Abuzer Dirican
Medicina 2026, 62(2), 358; https://doi.org/10.3390/medicina62020358 - 11 Feb 2026
Viewed by 1956
Abstract
Background and Objectives: Living donor hepatectomy is an essential component of liver transplantation programs, with donor safety representing the foremost priority. This study aimed to evaluate early postoperative complications in living liver donors and to identify clinical and demographic factors associated with [...] Read more.
Background and Objectives: Living donor hepatectomy is an essential component of liver transplantation programs, with donor safety representing the foremost priority. This study aimed to evaluate early postoperative complications in living liver donors and to identify clinical and demographic factors associated with complication risk using the Clavien–Dindo classification. Materials and Methods: A retrospective analysis was conducted on 502 consecutive living liver donors who underwent hepatectomy between August 2021 and May 2025. Donors received standardized preoperative evaluation, surgical management, and postoperative follow-up. Demographic characteristics, graft-related variables, remnant liver ratio, and clinical outcomes were recorded. Postoperative complications were graded using the Clavien–Dindo classification, with Grade ≥ IIIa defined as major complications. Univariable and multivariable logistic regression analyses were performed. Results: Postoperative complications occurred in 58 donors (11.6%; 95% CI: 9.0–14.6%), the majority of which were mild to moderate (Grades I and II). Biliary complications were the most frequent cause of morbidity. Major complications (≥Grade IIIa) were observed in 17 donors, while no Grade IV and V complications or mortalities were recorded. Donors with complications had significantly longer hospital stays (p = 0.0002). Although crude complication rates were higher among Turkish donors than foreign donors (13.9% vs. 7.5%, p = 0.043), this association did not remain statistically significant after multivariable adjustment. No independent associations were identified between complication risk and graft type, remnant liver ratio, graft volume, or BMI. Conclusions: Living donor hepatectomy was associated with a low rate of severe early postoperative complications under standardized protocols. However, given the retrospective design and limited structured long-term follow-up, these findings primarily reflect early postoperative safety. Biliary complications remain the most common postoperative issue. Further multicenter prospective studies with extended follow-up are needed to comprehensively assess long-term donor outcomes. Full article
(This article belongs to the Special Issue Liver Surgery: Current Treatment and Future Options)
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