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Transforming Liver Transplantation: Cutting-Edge Surgical Approaches and Clinical Care

A Special Issue of Medicina (ISSN 1648-9144) belonging to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 749

Editor


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Guest Editor
MedStar Georgetown Transplant Institute, Washington, DC, USA
Interests: organ transplant; liver transplant; kidney transplant; pancreas transplant; intestine transplant multivisceral transplant; xenotransplant; HPB surgery; liver resection pancreas resection; HCC; CCA; colorectal liver metastsis

Special Issue Information

Dear Colleagues,

Liver transplantation remains the definitive therapy for end-stage liver disease, acute liver failure, and selected hepatic malignancies. Despite major progress in surgical technique and perioperative care, the field continues to face critical challenges, including organ scarcity, increasing recipient complexity, and the need to optimize long‑term graft function. Recent advances in donor management, organ preservation, and intraoperative technologies are reshaping clinical practice and creating new opportunities to improve outcomes across the transplant continuum.

This Special Issue, Transforming Liver Transplantation: Cutting‑Edge Surgical Approaches and Clinical Care, focuses on emerging evidence that is driving the next phase of innovation in transplantation. We welcome original research, clinical studies, and high‑quality reviews that address contemporary surgical strategies, novel preservation platforms, and multidisciplinary perioperative management. Particular interest is given to work that evaluates clinical effectiveness, refines patient selection, enhances graft utilization, or integrates precision tools to support decision‑making. By assembling these contributions, the Special Issue aims to advance evidence‑based practice and support the translation of new technologies into routine clinical care.

Topics of interest include, but are not limited to:

  • Minimally invasive and robotic techniques in liver transplantation;
  • Normothermic and hypothermic machine perfusion and other preservation innovations;
  • Donor pool expansion, including DCD and extended‑criteria grafts;
  • Intraoperative monitoring, hemodynamic optimization, and anesthetic strategies;
  • Immunosuppression, tolerance‑oriented approaches, and biomarkers of graft function;
  • Prevention and management of early and late post‑transplant complications;
  • Clinical applications of artificial intelligence, imaging analytics, and digital platforms.

Dr. Shekhar Gogna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver transplantation
  • machine perfusion
  • organ preservation
  • donor expansion
  • immunosuppression
  • perioperative management
  • surgical innovation
  • transplant oncology

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Published Papers (1 paper)

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Research

15 pages, 1688 KB  
Article
The Association of Flavin Mononucleotide and Lactate During Normothermic Regional Perfusion with Post-Transplant Liver Outcomes: An Exploratory Study
by Raphaël M. J. Fischer, Claire Cywes, Olivia Ong, Nicolas Muñoz, Sardar Din, Tobenna Ibeabuchi, Isabela Brown-Soler, Nadim Mahmud, Kelly Cederquist, Georgeine Smith, Stephanie Benko, Chase J. Wehrle, Elizabeth M. Sonnenberg, Matthew H. Levine, Samir Abu-Gazala, James F. Markmann, Kim M. Olthoff, Abraham Shaked, Frederick Vyas, Marty Sellers, Jeroen de Jonge, Keyue Sun, Andrea Schlegel and Peter L. Abtadd Show full author list remove Hide full author list
Medicina 2026, 62(9), 1622; https://doi.org/10.3390/medicina62091622 - 22 Aug 2026
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Abstract
Background and Objectives: Normothermic regional perfusion (NRP) is an effective technique to improve recipient outcomes. However, no valid methods for determining liver viability exist. Identifying relevant biological markers with clinical correlation to liver viability and recipient clinical outcomes is imperative to improve [...] Read more.
Background and Objectives: Normothermic regional perfusion (NRP) is an effective technique to improve recipient outcomes. However, no valid methods for determining liver viability exist. Identifying relevant biological markers with clinical correlation to liver viability and recipient clinical outcomes is imperative to improve decision-making. Materials and Methods: Fifty-four donors undergoing NRP and their recipients were included. FMN was measured at the start, 1 h, and end of NRP. Lactate was measured at the start, 30, 60, and 90 min of NRP. Primary outcomes were early allograft function using the early allograft dysfunction (EAD) criteria and the model for early allograft function (MEAF). Secondary outcomes included the association with donor warm ischemia time (DWIT), stratified by 30 min. Spearman’s rho assessed correlations. Results: Forty (74%) livers were transplanted, with 5 (12.5%) recipients developing EAD and the mean MEAF score was 3.13 (1.49). FMN at all time points was significantly greater in the EAD group compared to the non-EAD group and was significantly correlated with the MEAF score (Peak FMN: rho = 0.507, p = 0.001). FMN during perfusion did not differ between DWIT < and ≥30 min. Lactate levels were similar across all groups and did not discriminate for adverse allograft outcomes. However, lactate levels during perfusion were higher in the DWIT ≥ 30 min group. Conclusions: These findings suggest that during NRP, elevated FMN, but not lactate, is associated with early allograft function. Full article
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