Advances in Cholecystitis and Cholecystectomy, 2nd Edition

Dear Colleagues,

Acute cholecystitis is the most common complication of cholelithiasis and accounts for approximately one-third of surgical emergencies. Obstruction of the infundibulum or cystic duct by gallstones triggers inflammatory processes of varying severity, ranging from mild forms to severe cases associated with organ failure and sepsis. Laparoscopic cholecystectomy has become the gold standard treatment due to its clear advantages, including reduced postoperative pain, lower complication rates, and shorter hospital stays. Alongside advances in anesthesia and intensive care, laparoscopic approaches can now be performed safely even in elderly patients and those with multiple comorbidities.

Despite these advances, significant challenges remain in the management of difficult cases. Although its incidence has declined with the adoption of the critical view of safety (CVS) during dissection of Calot’s triangle, bile duct injury (BDI) remains a major concern in laparoscopic cholecystectomy and a leading cause of postoperative morbidity.

Key areas of ongoing research include the optimal timing of cholecystectomy, strategies to enhance postoperative recovery in elderly patients, identification of predictive biomarkers for complications, indications for percutaneous cholecystostomy, and the pathogenesis and management of acute acalculous cholecystitis. Additional topics of interest include, but are not limited to, intraoperative imaging techniques (such as indocyanine green fluorescence cholangiography), the role of robotic-assisted surgery, subtotal cholecystectomy in difficult gallbladders, management of bile duct injuries, antibiotic stewardship, enhanced recovery after surgery (ERAS) protocols, outcomes in high-risk and frail populations, and the impact of surgeon experience and training on patient outcomes.

We warmly invite you to contribute your original research, reviews, and clinical studies to this Special Issue.

Prof. Dr. Dragos Serban
Prof. Dr. Laurentiu Simion
Guest Editors

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• laparoscopic cholecystectomy
• cholecystitis
• cholelithiasis
• bile duct injury
• indocyanine green
• percutaneous cholecystostomy
• acute acalculous cholecystitis
• inflammatory biomarkers
• enhanced recovery after surgery (ERAS)

• Advances in Cholecystitis and Cholecystectomy in Medicina (7 articles)