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Medicina
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From the Perspective of Traditional Chinese Medicine: Clinical Presentations and...
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From the Perspective of Traditional Chinese Medicine: Clinical Presentations and Treatment of Depression

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Psychiatry".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 9265

Special Issue Editors

Dr. Ke Ma

E-Mail Website
Guest Editor
Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, No 4655, University Road, Changqing District, Jinan 250355, China
Interests: Chinese herbal medicines; disease–syndrome combination; mood disease; homeostasis
Prof. Dr. Zulqarnain Baloch

E-Mail Website
Guest Editor
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China
Interests: psychiatry; ethnopharmacology; natural products

Special Issue Information

Dear Colleagues,

Depression is a mental health disorder, which varies from mild to severe changes in mood and affects physical, mental and behavior health. Recent evidence indicates that depressive disorders may represent an interactive matrix of reciprocally interactive pathophysiology influenced by various factors, such as genes or the environment. The sustained stress to the individuals with genetic susceptibility leads to deficits of the HPA axis, imbalanced monoamine/cytokine, decreased neurogenesis and altered dynamics of connectivity in the reward and motivational circuitry. These mechanisms reduce neuroplasticity and impair the functional integrity of regulation neurocircuitry. Therefore, preventive and therapeutic strategies have been considered to avoid and treat this disease.

In this context, the drugs that regulate neurotransmitters, including selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors and tricyclic and monoamine oxidase inhibitors, are the most commonly prescribed antidepressants. However, these antidepressants only have relative success and can result in several side effects, particularly in chronic use. For these reasons, over the years, researchers have searched for alternative therapeutic strategies, particularly those that involve the use of Chinese herbal medicines.

This Special Issue aims to collect clinical and basic research, in addition to review articles and meta-analyses, that address the use of traditional Chinese medicine formulas, Chinese herbs, natural products, as either extracts or isolated compounds, and mon-drug therapy of traditional Chinese medicine (acupuncture, manipulation, five elements, musician, etc.) to treat depression. Therefore, we invite colleagues around the world to contribute manuscripts with in vitro, in vivo, and clinical studies that focus not only on the effects of natural products on the control of neurotransmitter levels, but also on the potential protection of connectivity in the reward and motivational circuitry.

Dr. Ke Ma
Prof. Dr. Zulqarnain Baloch
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chinese herbal medicines
  • syndrome
  • depression
  • multi-omics
  • pharmacological mechanisms

Published Papers (4 papers)

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Research

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10 pages, 305 KiB  
Article
Clinical Study on the Emotional Intervention of Patients with Asymptomatic and Mild Novel Coronavirus (COVID-19)
by Bo Lu, Wenli Shi, Xunjie Zhou, Deyu Fu, Lei Duan, Xiaoli He, Wenjing You, Junwei Gu and Xinyue Zhang
Medicina 2023, 59(5), 895; https://doi.org/10.3390/medicina59050895 - 6 May 2023
Cited by 1 | Viewed by 1444
Abstract
Background and Objectives: The aim was to explore the interventional effect of the traditional Chinese medicine (TCM) exercise of Tian Dan Shugan Tiaoxi on the emotions of patients with mild novel coronavirus (COVID-19). Materials and Methods: A total of 110 asymptomatic and mildly [...] Read more.
Background and Objectives: The aim was to explore the interventional effect of the traditional Chinese medicine (TCM) exercise of Tian Dan Shugan Tiaoxi on the emotions of patients with mild novel coronavirus (COVID-19). Materials and Methods: A total of 110 asymptomatic and mildly symptomatic COVID-19 patients from Hongkou Memorial Road Temporary Cabin Hospital and South Renji Hospital were selected between April 2022 and June 2022, and randomly divided into two groups: a control group and an intervention group. There were 55 participants in each group. The control group was treated with Lianhua Qingwen granules, and members of the intervention group were made to practice Tian Dan Shugan Tiaoxi (an exercise that soothes the liver and regulates emotions) every day for 5 days. The Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder questionnaire (GAD-7), and the Symptom Checklist 90 (SCL-90) were used to evaluate the data collected before and after the trial. Results: The incidence of anxiety and depression was high in the patients included in this study, at 73.64% and 69.09%, respectively. After intervention, the scores of the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder questionnaire (GAD-7) in the two groups had decreased in comparison with those recorded before intervention (p < 0.05). The PHQ-9 and GAD-7 scores in the intervention group were significantly better than those of the control group (p < 0.05). The factors of somatization, depression, anxiety, hostility, and fear in the SCL-90 in the intervention group were significantly improved after intervention, and generally, better than those in the control group (p < 0.05). Conclusions: Patients infected with novel coronavirus in shelter hospitals have different degrees of emotional abnormalities. Tian Dan Shugan Tiaoxi can reduce the anxiety and depression of people with mild novel coronavirus, and it can be practiced clinically to improve the recovery rate among infected people. Full article
(This article belongs to the Special Issue From the Perspective of Traditional Chinese Medicine: Clinical Presentations and Treatment of Depression)
12 pages, 2698 KiB  
Article
Using Text Mining and Data Visualization Approaches for Investigating Mental Illness from the Perspective of Traditional Chinese Medicine
by Wan-Ling Lin, Yu-Chi Liang, Kuo-Hsuan Chung, Ping-Ho Chen and Yung-Chun Chang
Medicina 2023, 59(2), 196; https://doi.org/10.3390/medicina59020196 - 18 Jan 2023
Cited by 1 | Viewed by 2090
Abstract
Background and Objectives. Anxiety and depressive disorders are the most prevalent mental disorders, and due to the COVID-19 pandemic, more people are suffering from anxiety and depressive disorders, and a considerable fraction of COVID-19 survivors have a variety of persistent neuropsychiatric problems after [...] Read more.
Background and Objectives. Anxiety and depressive disorders are the most prevalent mental disorders, and due to the COVID-19 pandemic, more people are suffering from anxiety and depressive disorders, and a considerable fraction of COVID-19 survivors have a variety of persistent neuropsychiatric problems after the initial infection. Traditional Chinese Medicine (TCM) offers a different perspective on mental disorders from Western biomedicine. Effective management of mental disorders has become an increasing concern in recent decades due to the high social and economic costs involved. This study attempts to express and ontologize the relationships between different mental disorders and physical organs from the perspective of TCM, so as to bridge the gap between the unique terminology used in TCM and a medical professional. Materials and Methods. Natural language processing (NLP) is introduced to quantify the importance of different mental disorder descriptions relative to the five depots and two palaces, stomach and gallbladder, through the classical medical text Huangdi Neijing and construct a mental disorder ontology based on the TCM classic text. Results. The results demonstrate that our proposed framework integrates NLP and data visualization, enabling clinicians to gain insights into mental health, in addition to biomedicine. According to the results of the relationship analysis of mental disorders, depots, palaces, and symptoms, the organ/depot most related to mental disorders is the heart, and the two most important emotion factors associated with mental disorders are anger and worry & think. The mental disorders described in TCM are related to more than one organ (depot/palace). Conclusion. This study complements recent research delving into co-relations or interactions between mental status and other organs and systems. Full article
(This article belongs to the Special Issue From the Perspective of Traditional Chinese Medicine: Clinical Presentations and Treatment of Depression)
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Review

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14 pages, 1163 KiB  
Review
Research Progress on the Pharmacodynamic Mechanisms of Sini Powder against Depression from the Perspective of the Central Nervous System
by Zhongqi Shen, Meng Yu and Zhenfei Dong
Medicina 2023, 59(4), 741; https://doi.org/10.3390/medicina59040741 - 10 Apr 2023
Viewed by 1736
Abstract
Depression is a highly prevalent emotional disorder characterized by persistent low mood, diminished interest, and loss of pleasure. The pathological causes of depression are associated with neuronal atrophy, synaptic loss, and neurotransmitter activity decline in the central nervous system (CNS) resulting from injuries, [...] Read more.
Depression is a highly prevalent emotional disorder characterized by persistent low mood, diminished interest, and loss of pleasure. The pathological causes of depression are associated with neuronal atrophy, synaptic loss, and neurotransmitter activity decline in the central nervous system (CNS) resulting from injuries, such as inflammatory responses. In Traditional Chinese Medicine (TCM) theory, patients with depression often exhibit the liver qi stagnation syndrome type. Sini Powder (SNP) is a classic prescription for treating such depression-related syndrome types in China. This study systematically summarized clinical applications and experimental studies of SNP for treatments of depression. We scrutinized the active components of SNP with blood–brain barrier (BBB) permeability and speculated about the corresponding pharmacodynamic pathways relevant to depression treatment through intervening in the CNS. Therefore, this article can enhance our understanding of SNP’s pharmacological mechanisms and formula construction for depression treatment. Moreover, a re-demonstration of this classic TCM prescription in the modern-science language is of great significance for future drug development and research. Full article
(This article belongs to the Special Issue From the Perspective of Traditional Chinese Medicine: Clinical Presentations and Treatment of Depression)
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17 pages, 357 KiB  
Review
A Chinese Classical Prescription Chaihu Shugan Powder in Treatment of Post-Stroke Depression: An Overview
by Zu Gao, Yuan Wang and Huayun Yu
Medicina 2023, 59(1), 55; https://doi.org/10.3390/medicina59010055 - 27 Dec 2022
Cited by 2 | Viewed by 2541
Abstract
Post-stroke depression (PSD) is the most common mental health problem after a stroke with an incidence of up to 33%. PSD has a negative impact on the rehabilitation and recovery of motor and cognitive dysfunction after a stroke and significantly increases the chance [...] Read more.
Post-stroke depression (PSD) is the most common mental health problem after a stroke with an incidence of up to 33%. PSD has a negative impact on the rehabilitation and recovery of motor and cognitive dysfunction after a stroke and significantly increases the chance of the recurrence of neurovascular events. At present, medication is the preferred method of coping with PSD. Modern medicine is still unclear regarding the pathogenesis of PSD, with clinical drug treatment mostly using antidepressants, such as selective serotonin reuptake inhibitor (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs). However, a high proportion of patients fail to show an adequate antidepressant response and have adverse reactions after taking antidepressants. In recent years, as the advantages of traditional Chinese medicine (TCM) in clinical treatment continue to emerge, Chinese herbal and TCM formulae have begun to enter the awareness of Chinese scholars and even scholars around the world. As a classic formula with a history of more than 400 years, Chaihu Shugan powder (CHSG) has great advantages in the clinical treatment of PSD. Based on existing clinical and experimental studies, this article comprehensively analyzes clinical cases, mechanisms of action, and drug and chemical effects of CHSG in the treatment of PSD in order to provide more clinical experience and experimental theoretical support for CHSG in the treatment of PSD. Full article
(This article belongs to the Special Issue From the Perspective of Traditional Chinese Medicine: Clinical Presentations and Treatment of Depression)
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