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Medicina
Special Issues
Analysis and Investigation of Inorganic Particles with Human Tissues
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Analysis and Investigation of Inorganic Particles with Human Tissues

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Pulmonary".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 5159

Special Issue Editor

Dr. Yasuhiko Koga

E-Mail Website
Guest Editor
Department of Allergy and Respiratory Medicine, Gunma University Graduate School of Medicine, Gunma 371-8510, Japan
Interests: idiopathic pulmonary fibrosis; elemental analysis; PIXE; allergy; anaphylaxis; asthma; smooth muscle contraction; CREB phosphorylation; environmental health

Special Issue Information

Dear Colleagues,

Recently, the American Thoracic Society, in coordination with the European Respiratory Society, published a statement describing the significance of workplace inhalational hazards that add to the burden of nonmalignant lung diseases, including asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, sarcoidosis, and pulmonary alveolar proteinosis (Blanc et al., 2019. 1312–1334 AJRCCM). It is thought that the incidence of nonmalignant lung diseases associated with environmental elemental exposure will be much higher than expected.

In addition to pulmonary disorders, autoimmune diseases have also been known to be associated with elemental exposure. Vasculitis, such as granulomatosis with polyangiitis or microscopic polyangiitis, is known to be associated with occupational silica exposure. Systemic sclerosis and rheumatoid arthritis are also associated with heavy metal or silica exposure. In addition, PM 2.5 is also harmful, causing cardiovascular diseases. However, elemental analysis has not been intensely focused on nonmalignant lung and systemic vascular diseases, differentiating it from pneumoconiosis or malignant mesothelioma.

The purpose of this Special Issue is to connect recent knowledge acquired from applying elemental analysis to clinical medicine with the pathogenetic elucidation of human diseases. For this Special Issue, we encourage researchers to investigate the interaction between environmental elemental exposure and human diseases. We welcome preliminary studies, original research papers, and systematic reviews, as well as meta-analyses.

Dr. Yasuhiko Koga
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Elemental analysis
  • PIXE
  • Respiratory disease
  • asthma
  • COPD
  • Vasculitis
  • MPA
  • GPA
  • PM2.5
  • autoimmune disease.

Published Papers (2 papers)

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10 pages, 3714 KiB  
Article
Relationship between Trace Element in Tumor and Prognosis in Lung Cancer Patients
by Hirotaka Saikawa, Hiromi Nagashima, Katsuya Cho, Ryosuke Chiba, Koichiro Sera, Wataru Shigeeda, Makoto Tomoyasu, Hiroyuki Deguchi, Fumiaki Takahashi, Hajime Saito, Tamotsu Sugai and Makoto Maemondo
Medicina 2021, 57(3), 209; https://doi.org/10.3390/medicina57030209 - 26 Feb 2021
Cited by 6 | Viewed by 1869
Abstract
Background and Objectives: This study aimed to observe the relationship between trace element concentrations in lung tissue from lung non-small cell lung carcinoma (NSCLC) patients and prognosis. Materials and Methods: The concentrations of various trace elements in the lung tissues were measured by [...] Read more.
Background and Objectives: This study aimed to observe the relationship between trace element concentrations in lung tissue from lung non-small cell lung carcinoma (NSCLC) patients and prognosis. Materials and Methods: The concentrations of various trace elements in the lung tissues were measured by a particle-induced X-ray emission (PIXE) system, and the results were analyzed for statistical significance. Eight essential trace elements, Cr, Mn, Fe, Co, Cu, Zn, Se, and Mo, were analyzed. We investigated the relationship between trace element concentrations and disease-free survival (DFS) and overall survival (OS) in NSCLC patients. Results: A total of 129 NSCLC patients and 20 control patients were included in this study. As for DFS, Co was the only element that showed a significant difference, and the high Co group had better DFS (HR: 0.352, 95% CI = 0.128–0.97). No significant difference was observed for Cr, Mn, Fe, Se, or Mo, but DFS tended to be better in the high trace element group. No significant difference was observed for Cu and Zn, but DFS tended to be good in the low trace element group. As for OS, Cr was the only element that showed a significant difference, and the high Cr element group had better OS (HR: 0.477, 95% CI = 0.128–0.97). Conclusions: This study suggests that the prognosis is good in lung cancer cases with high intratumoral concentrations of Co and Cr. The dynamics of trace elements in body and in tumor tissue have not been well established, and we consider that more research is necessary in the future. Full article
(This article belongs to the Special Issue Analysis and Investigation of Inorganic Particles with Human Tissues)
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12 pages, 9525 KiB  
Case Report
Pneumoconiosis with a Sarcoid-Like Reaction Other than Beryllium Exposure: A Case Report and Literature Review
by Fumiko Hayashi, Takashi Kido, Noriho Sakamoto, Yoshiaki Zaizen, Mutsumi Ozasa, Mitsuru Yokoyama, Hirokazu Yura, Atsuko Hara, Hiroshi Ishimoto, Hiroyuki Yamaguchi, Taiga Miyazaki, Yasushi Obase, Yuji Ishimatsu, Yoshinobu Eishi, Junya Fukuoka and Hiroshi Mukae
Medicina 2020, 56(11), 630; https://doi.org/10.3390/medicina56110630 - 22 Nov 2020
Cited by 4 | Viewed by 2920
Abstract
Background: Chronic beryllium disease (CBD) is a granulomatous disease that resembles sarcoidosis but is caused by beryllium. Clinical manifestations similar to those observed in CBD have occasionally been reported in exposure to dusts of other metals. However, reports describing the clinical, radiographic, and [...] Read more.
Background: Chronic beryllium disease (CBD) is a granulomatous disease that resembles sarcoidosis but is caused by beryllium. Clinical manifestations similar to those observed in CBD have occasionally been reported in exposure to dusts of other metals. However, reports describing the clinical, radiographic, and pathological findings in conditions other than beryllium-induced granulomatous lung diseases, and detailed information on mineralogical analyses of metal dusts, are limited. Case presentation: A 51-year-old Japanese man with rapidly progressing nodular shadows on chest radiography, and a 10-year occupation history of underground construction without beryllium exposure, was referred to our hospital. High-resolution computed tomography showed well-defined multiple centrilobular and perilobular nodules, and thickening of the intralobular septa in the middle and lower zones of both lungs. No extrathoracic manifestations were observed. Pathologically, the lung specimens showed 5–12 mm nodules with dust deposition and several non-necrotizing granulomas along the lymphatic routes. X-ray analytical electron microscopy of the same specimens revealed aluminum, iron, titanium, and silica deposition in the lung tissues. The patient stopped smoking and changed his occupation to avoid further dust exposure; the chest radiography shadows decreased 5 years later. Conclusion: The radiological appearances of CBD and sarcoidosis are similar, although mediastinal or hilar lymphadenopathy is less common in CBD and is usually seen in the presence of parenchymal opacities. Extrathoracic manifestations are also rare. Despite limited evidence, these findings are similar to those observed in pneumoconiosis with a sarcoid-like reaction due to exposure to dust other than of beryllium. Aluminum is frequently detected in patients with pneumoconiosis with a sarcoid-like reaction and is listed as an inorganic agent in the etiology of sarcoidosis. It was also detected in our patient and may have contributed to the etiology. Additionally, our case suggests that cessation of dust exposure may contribute to improvement under the aforementioned conditions. Full article
(This article belongs to the Special Issue Analysis and Investigation of Inorganic Particles with Human Tissues)
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