Special Issue "Celiac Disease and Non-celiac Gluten Sensitivity"

A special issue of Medicina (ISSN 1010-660X). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 10 April 2021.

Special Issue Editor

Prof. Luis Rodrigo
Guest Editor
Hospital Universitario Central de Asturias (HUCA), Gastroenterology Unit, Oviedo, Spain
Interests: Celiac disease; Non-Celiac gluten sensitivity; autoimmune-related diseases
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Celiac disease (CD) is a gluten-induced immune-mediated enteropathy, characterized by the presence of specific serum autoantibodies and genetic markers. Although the inflammatory process specifically targets the intestinal mucosa, patients may present with gastrointestinal and/or extraintestinal signs or symptoms,, suggesting that CD is an autoimmune systemic disease.

Non-Celiac gluten sensitivity (NCGS) is diagnosed in individuals who do not have CD or wheat allergy (WA), but who have intestinal and/or extraintestinal symptoms related to ingestion of gluten-containing grains, with symptomatic improvement on their withdrawal. The clinical variability and the lack of validated biomarkers for NCGS, make establishing the prevalence, reaching a diagnosis, and further study of this condition difficult.

Nevertheless, it is possible to differentiate specific gluten-related disorders from other conditions based on currently available investigations and algorithms. Clinicians cannot distinguish between Celiac disease and Non-Celiac gluten sensitivity by symptoms, as they are similar in both. Therefore, screening for CD must occur before a gluten-free diet (GFD) is implemented, since once a patient initiates this diet, testing for CD is no longer accurate.

It is useful to recall that the prevalence of gluten-related disorders is rising, and that many individuals are empirically trying a GFD, for a variety of signs and symptoms.

Prof. Luis Rodrigo
Guest Editor

Manuscript Submission Information

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  • Celiac disease/diagnosis
  • Celiac disease/immunology
  • Celiac disease/differential diagnosis
  • Celiac disease/treatment/evolution
  • Non-Celiac gluten sensitivity/diagnosis
  • Non-Celiac gluten sensitivity/immunology
  • Non-Celiac gluten sensitivity/differential diagnosis
  • Non-Celiac gluten sensitivity/treatment/evolution

Published Papers (1 paper)

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Open AccessArticle
Prevalence of Adverse Reactions to Glutenand People Going on a Gluten-Free Diet:A Survey Study Conducted in Brazil
Medicina 2020, 56(4), 163; https://doi.org/10.3390/medicina56040163 - 04 Apr 2020
Cited by 3
Background: The prevalence of gluten-related disorders (GRD) and adherence to a gluten-free diet (GFD) remains unknown in Brazilian population and there is no published information on the scientific literature about the proportion of Brazilians that were diagnosed with a gluten-related disorder. Thus, the [...] Read more.
Background: The prevalence of gluten-related disorders (GRD) and adherence to a gluten-free diet (GFD) remains unknown in Brazilian population and there is no published information on the scientific literature about the proportion of Brazilians that were diagnosed with a gluten-related disorder. Thus, the aim of this work was to estimate the prevalence of GRDs and adherence to a GFD by self-report in adult Brazilian population. Materials and Methods: A questionnaire-based cross-sectional study was conducted in two Brazilian cities. Results: The response rate was 93.2% (1630/1749). The self-reported prevalence rates were (95% CI): adverse reactions to gluten 10.06% (8.64–11.62); gluten sensitivity 2.33% (1.65–3.18); physician-diagnosed celiac disease 0.3% (0.09–0.71); non-celiac gluten sensitivity 1.71% (1.14–2.47); wheat allergy 0.79% (0.42–1.36); adherence to gluten-free diet 7.48% (6.25–8.87); gluten avoiders 15.21% (13.5–17.05). Among those who were following a GFD (n = 122), 65.6% (n = 80) of them reported that they did not develop symptoms after wheat/gluten ingestion and 50% (n = 61) were following the diet without medical/dietitian advice. The main motivation for following a GFD in the self-reported and non-self-reported gluten sensitivity groups were the symptoms triggered after wheat/gluten ingestion (86.8%) and weight control (57.1%), respectively. Conclusions: Implementation of programs to increase awareness about GRDs among healthcare professionals and giving scientifically sound information to the general population about the risks and benefits for following a GFD are desirable actions in Brazil. The results also add to the growing body of evidence for highlighting the under-diagnosis of GRD and the trend for following a GFD in Latin America. Full article
(This article belongs to the Special Issue Celiac Disease and Non-celiac Gluten Sensitivity)
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