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Medicina
Special Issues
Exploring Novel Biomarkers
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Exploring Novel Biomarkers

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Sports Medicine and Sports Traumatology".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 6549

Special Issue Editors

Dr. Radoslav Zamborský

E-Mail Website
Guest Editor
Orthopaedic Clinic, Faculty of Medicine, Comenius University in Bratislava and National Institute of Children's Diseases, Bratislava, Slovakia
Interests: cartilage repair; articular cartilage; knee injuries; knee surgery; sports injuries; arthroplasty; fracture; hip; trauma surgery; hip and knee arthroplasty; hip arthroplasty; adult stem cells; chondrocytes; tissue engineering; cartilage; arthroscopy; osteoarthritis medicine; bone cartilage regeneration; musculoskeletal imaging; knee arthroplasty; sports cell pediatric orthopedics; regenerative medicine; knee osteoarthritis
Dr. Štefan Harsányi

E-Mail Website
Guest Editor
Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Sasinkova 4, 811 08 Bratislava, Slovakia
Interests: cell biology; molecular biology; genetics; cancer research; biomarkers; biomarkers research; developmental dysplasia of the hip; biotechnology; sports medicine

Special Issue Information

Dear Colleagues,

Investigating the complexities of various diseases necessitates the exploration of novel biomarkers, as well as the evaluation of established ones and their potential synergistic use in diagnostic panels. Biomarkers play a pivotal role in advancing diagnostic processes, medical knowledge, and patient care. Our collective research efforts are directed towards uncovering the intricate pathways within cells and tissues, utilizing approaches from genomics, proteomics, metabolomics, and beyond. These investigations elucidate the molecular intricacies underlying numerous health conditions, facilitating the identification of distinctive biomarkers. Each identified biomarker enhances the precision of diagnosis, enables personalized treatment strategies, and improves disease monitoring.

This Special Issue will highlight research articles and review papers focusing on biomarkers across a wide array of diseases. We invite contributions from researchers, clinicians, and data scientists eager to present their original work. The emphasis will be on pioneering biomarkers that facilitate earlier and more accurate diagnoses, optimize patient stratification, and support tailored therapeutic approaches for various conditions, including but not limited to cancers, autoimmune diseases, cardiovascular diseases, neurodegenerative disorders, metabolic disorders, and infectious diseases.

Topics concerning these biomarkers belong to, e.g.:

  • Non-coding RNA molecules;
  • Genetic and epigenetic biomarkers;
  • Proteomic analyses;
  • Metabolomic profiling;
  • Extracellular vesicles;
  • Predictive biomarker discovery;
  • Imaging biomarkers;
  • Inflammatory cytokines and chemokines;
  • The microbiome;
  • Multi-omics integration.

In this Special Issue, we invite our colleagues on this journey, where we find ourselves united by a shared commitment to pioneering research, innovative discovery, and the prospect of a healthier future for our patients. Together, we will illuminate the path forward and strive to find a better tomorrow.

Dr. Radoslav Zamborský
Dr. Štefan Harsányi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • disease pathways
  • genomics
  • proteomics
  • metabolomics
  • non-coding RNAs
  • epigenetics
  • extracellular vesicles
  • predictive biomarkers
  • imaging biomarkers

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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13 pages, 537 KiB  
Article
Analysis of the Level of Adiponectin and Selected Cytokines in Patients with Knee Osteoarthritis
by Iosif Ilia, Paula Diana Ciordas, Diana Nitusca, Alina Anton and Catalin Marian
Medicina 2024, 60(4), 571; https://doi.org/10.3390/medicina60040571 - 30 Mar 2024
Cited by 5 | Viewed by 2001
Abstract
Background and Objectives: Knee osteoarthritis (KOA) is a degenerative disease that is continuously targeting people of different ages, but especially the elderly population, the number of which tends to increase continuously at the global level. Apart from age, excess weight can influence [...] Read more.
Background and Objectives: Knee osteoarthritis (KOA) is a degenerative disease that is continuously targeting people of different ages, but especially the elderly population, the number of which tends to increase continuously at the global level. Apart from age, excess weight can influence the evolution of the disease, with obesity being associated with a weak inflammation stage and an imbalance between pro-inflammatory and anti-inflammatory cytokines. The present work aimed to analyze specific biomarkers, namely ACRP-30, IL-10, TNF-α, and IL-6, in knee synovial fluid, and correlate them with KOA patients’ clinical data, radiographic changes, and functional and pain scores. Materials and Methods: 24 subjects with KOA and over 50 years of age participate in the present study. Synovial fluid was harvested using ultrasound guidance from the target knees of the enrolled KOA patients, and the levels of ACRP-30, IL-10, TNF-α, and IL-6 were measured using enzyme-linked immunosorbent assays (ELISA). All patients underwent a supine X-ray at the target knee and were classified using Kellgren–Lawrence (K–L) grading. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) was used to assess self-reported physical function, pain, and stiffness. Results: The obtained results highlighted a significant correlation between age and adiponectin level (p = 0.0451, r = −0.412). Also, the IL-10 values are lower in cases where the intensity of the pain is more pronounced (p = 0.0405, r = −0.421). In addition, analyzing the data by gender, it was observed that in the case of males, stiffness is more related to age (p = 0.0079, r = 0.7993), compared to women (p = 0.0203, r = 0.6223). In the case of women, the progression of the disease tends to increase more intensively the WOMAC score’s total values (p = 0.00031, r = 0.8342), compared with men (p = 0.0289, r = 7013). Regarding interleukins and BMI, significant correlations were observed only in the case of men. Conclusions: A significant correlation between age and adiponectin, and adiponectin and IL-6, suggests that advanced age may contribute to adiponectin reduction. Comparing men with women, it was observed that men’s age is more related to rigidity, and IL-6 and IL-10 are directly correlated to BMI; in addition, women seem to be more sensitive to pain and stiffness. Full article
(This article belongs to the Special Issue Exploring Novel Biomarkers)
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14 pages, 365 KiB  
Review
Psoriasis and Psoriatic Arthritis—Associated Genes, Cytokines, and Human Leukocyte Antigens
by Marek Zalesak, Lubos Danisovic and Stefan Harsanyi
Medicina 2024, 60(5), 815; https://doi.org/10.3390/medicina60050815 - 16 May 2024
Cited by 6 | Viewed by 3985
Abstract
In recent years, research has intensified in exploring the genetic basis of psoriasis (PsO) and psoriatic arthritis (PsA). Genome-wide association studies (GWASs), including tools like ImmunoChip, have significantly deepened our understanding of disease mechanisms by pinpointing risk-associated genetic loci. These efforts have elucidated [...] Read more.
In recent years, research has intensified in exploring the genetic basis of psoriasis (PsO) and psoriatic arthritis (PsA). Genome-wide association studies (GWASs), including tools like ImmunoChip, have significantly deepened our understanding of disease mechanisms by pinpointing risk-associated genetic loci. These efforts have elucidated biological pathways involved in PsO pathogenesis, particularly those related to the innate immune system, antigen presentation, and adaptive immune responses. Specific genetic loci, such as TRAF3IP2, REL, and FBXL19, have been identified as having a significant impact on disease development. Interestingly, different genetic variants at the same locus can predispose individuals to either PsO or PsA (e.g., IL23R and deletion of LCE3B and LCE3C), with some variants being uniquely linked to PsA (like HLA B27 on chromosome 6). This article aims to summarize known and new data on the genetics of PsO and PsA, their associated genes, and the involvement of the HLA system and cytokines. Full article
(This article belongs to the Special Issue Exploring Novel Biomarkers)
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