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Medicina
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Acute Pancreatitis: From Pathogenesis to Treatment
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Acute Pancreatitis: From Pathogenesis to Treatment

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1070

Special Issue Editors

Prof. Dr. Katarzyna Aleksandra Kuśnierz

E-Mail Website
Guest Editor
Department of Gastrointestinal Surgery, Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice, Poland
Interests: general surgery; pancreatic surgery; neuroendocrine tumors
Dr. Ewa Grudzińska

E-Mail Website
Guest Editor Assistant
Department of Gastrointestinal Surgery, Medical University of Silesia, Poniatowskiego 15, 40-055 Katowice, Poland.
Interests: general surgery; pancreatic surgery; proctology; phlebology

Special Issue Information

Dear Colleagues,

Acute pancreatitis is a common clinical condition with a steadily increasing incidence and a broad spectrum of severity. Although the majority of cases are mild, approximately 10% of patients develop severe disease associated with significant local and systemic complications. Most commonly caused by gallstones and alcohol consumption, acute pancreatitis is characterized by a complex pathogenesis and may pose substantial diagnostic and therapeutic challenges.

While diagnostic and therapeutic strategies have remained largely unchanged for many years, recent advances, particularly in endoscopic techniques and pharmacological research, have contributed to important updates in clinical guidelines. As acute pancreatitis is managed by both gastroenterologists and surgeons, careful diagnostic evaluation and sound clinical judgment are essential, especially in cases of disease progression or clinical deterioration.

This Special Issue will highlight novel insights into the pathogenesis of acute pancreatitis, present outcomes of contemporary treatment strategies, and provide an up-to-date overview for clinical practitioners. We welcome contributions addressing the roles of pharmacological therapy, endoscopic interventions, and surgical management in modern clinical practice, as well as innovative basic and translational research focused on disease mechanisms. Manuscripts discussing current challenges and emerging perspectives related to the treatment of acute pancreatitis are particularly encouraged.

We invite authors to contribute their research to this Special Issue and look forward to receiving your submissions. Original studies and reviews are welcome.

Prof. Dr. Katarzyna Aleksandra Kuśnierz
Guest Editor

Dr. Ewa Grudzińska
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute pancreatitis
  • pathogenesis
  • endoscopic management
  • cystogastrostomy
  • EUS
  • ERCP
  • pancreatic surgery
  • open abdomen
  • negative pressure dressing
  • parenteral nutrition

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Published Papers (2 papers)

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Research

16 pages, 1868 KB  
Article
The Prevalence of Pancreas Divisum and Its Association with Pancreatic Diseases: A Systematic Review and Meta-Analysis
by Worawit Suphamungmee, Napawan Taradolpisut, Laphatrada Yurasakpong, Thanyaporn Senarai and Athikhun Suwannakhan
Medicina 2026, 62(5), 953; https://doi.org/10.3390/medicina62050953 - 13 May 2026
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Abstract
Background and Objectives: Pancreas divisum (PD) is the most common congenital anomaly of the pancreatic ductal system and has been suggested to contribute to pancreatic pathology. However, its true prevalence and relationship with pancreatic diseases remain debated. This systematic review and meta-analysis [...] Read more.
Background and Objectives: Pancreas divisum (PD) is the most common congenital anomaly of the pancreatic ductal system and has been suggested to contribute to pancreatic pathology. However, its true prevalence and relationship with pancreatic diseases remain debated. This systematic review and meta-analysis aimed to estimate the global prevalence of PD and evaluate its association with pancreatic disease. Materials and Methods: A comprehensive search of Google Scholar, Scopus, and PubMed was conducted to identify studies reporting the prevalence of PD across all populations and diagnostic modalities. Pooled prevalence estimates were calculated using a random-effects model. Between-study heterogeneity was assessed using the I2 statistic, and publication bias was evaluated using Egger’s test. Results: A total of 117 studies comprising 193,672 subjects were included. The pooled global prevalence of PD was 11.1% (95% CI: 8.0–14.2%) with substantial heterogeneity (I2 = 99.96%). PD prevalence was higher among individuals with pancreatic disease (18.7%) compared with cadaveric/autopsy studies (8.8%), healthy individuals (5.6%), and consecutive patients (4.7%). Both complete and incomplete PD were more common in subjects with pancreatic diseases. Among PD subtypes, type I was the most prevalent. Egger’s test demonstrated significant publication bias (p < 0.01). Conclusions: PD affects approximately one in ten individuals worldwide and appears more prevalent in patients with pancreatic diseases. However, this finding should be interpreted with caution due to potential selection bias from predominantly ERCP-based studies. Full article
(This article belongs to the Special Issue Acute Pancreatitis: From Pathogenesis to Treatment)
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17 pages, 1523 KB  
Article
Dynamic Assessment of Modified EASIX (m-EASIX) at 48 Hours Predicts Adverse Outcomes in Acute Pancreatitis: A Propensity Score-Matched Study
by Hikmet Öztop, Enes Yavuz, Nevriye Gül Ada Tak, Fatih Eren and Fazıl Çağrı Hunutlu
Medicina 2026, 62(3), 568; https://doi.org/10.3390/medicina62030568 - 18 Mar 2026
Viewed by 467
Abstract
Background and Objectives: Early risk stratification in acute pancreatitis (AP) remains challenging, particularly for identifying patients who initially appear low-risk but later develop complications. The Modified Endothelial Activation and Stress Index (m-EASIX) reflects endothelial injury and systemic inflammation. This study evaluated the [...] Read more.
Background and Objectives: Early risk stratification in acute pancreatitis (AP) remains challenging, particularly for identifying patients who initially appear low-risk but later develop complications. The Modified Endothelial Activation and Stress Index (m-EASIX) reflects endothelial injury and systemic inflammation. This study evaluated the prognostic value of dynamic 48 h m-EASIX assessment for predicting adverse clinical outcomes in AP. Materials and Methods: This retrospective cohort study included adult patients hospitalized with AP between January 2020 and June 2025. Propensity score matching (1:1) was performed using age, sex, BISAP score and etiology. Laboratory parameters were recorded at admission and at 48 h. Adverse outcomes were defined as prolonged hospitalization (≥8 days) and/or pancreatic necrosis, abscess, intensive care unit admission or in-hospital mortality. Multivariable logistic regression was used to identify independent predictors of adverse outcomes. Receiver operating characteristic (ROC) analysis evaluated the predictive performance of m-EASIX and compared it with BISAP and Ranson scores. Results: A total of 258 patients were included in the initial cohort, of whom 93 experienced an adverse clinical course. After propensity score matching, 170 patients remained in the final analysis (85 per group). The 48 h m-EASIX score was independently associated with adverse outcomes in both unmatched and matched cohorts. ROC analysis showed a moderate discrimination for composite outcomes (AUC ≈ 0.76) and a stronger discrimination for hard outcomes (AUC up to 0.867). In all analyses, m-EASIX significantly outperformed BISAP and Ranson scores (DeLong test p < 0.001). Dynamic risk reclassification showed that m-EASIX identified a subgroup of patients initially classified as low-risk by BISAP who later developed adverse outcomes. Conclusions: The dynamic assessment of m-EASIX at 48 h provides additional prognostic information for early risk stratification in AP and may help identify patients at an increased risk of unfavorable clinical courses. Full article
(This article belongs to the Special Issue Acute Pancreatitis: From Pathogenesis to Treatment)
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