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Medicina
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Advances in Acute Myocardial Infarction
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Advances in Acute Myocardial Infarction

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 10 December 2025 | Viewed by 8010

Special Issue Editors

Dr. Šime Manola

E-Mail Website
Guest Editor
Department of Cardiovascular Medicine, Dubrava University Hospital, 10000 Zagreb, Croatia
Interests: electrophysiology; interventional cardiology
Dr. Ivana Jurin

E-Mail Website
Guest Editor Assistant
Department for Cardiovascular Diseases, Dubrava University Hospital, 10000 Zagreb, Croatia
Interests: interventional cardiology; lipidology; heart failure

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue entitled “Advances in Acute Myocardial Infarction” which will be published in the MDPI journal Medicina (Q1). Despite the progress of modern medicine in prevention, diagnosis, and treatment, acute myocardial infarction is still the most common single cause of death in developed countries.

Owing to recent advances in early reperfusion strategies, pharmacological therapy, standardized care, and the identification of vulnerable patient subsets, the prognosis of acute myocardial infarction has improved. However, there is still considerable room for improvement.

This Special Issue addresses the continuous development concerning clinical diagnosis and treatment of acute myocardial infarction, as well as the establishment and validation of a prediction model for the nonrecovery of left ventricular ejection fraction in acute myocardial infarction and predictors of recurrent acute myocardial infarction despite successful percutaneous coronary intervention.

You are invited to submit your manuscript to this Special Issue which aims to offer a complex and current overview of the existent new research topics related to acute myocardial infarction, expanding the current knowledge and adding important insights related to the management of patients with acute myocardial infarction to contribute to the continuous development in the dentistry field.

Dr. Šime Manola
Guest Editor

Dr. Ivana Jurin
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • percutaneous coronary intervention
  • heart failure
  • lipid-lowering therapy
  • SGLT2 inhibitors
  • multivessel disease
  • beta blockers
  • prasugrel
  • ticagrelor
  • semaglutide

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

7 pages, 490 KiB  
Article
Sex Differences in the In-Hospital Mortality of Patients with Acute Myocardial Infarction: A Cross-Sectional Study in 36 Hospitals Across Germany
by Karel Kostev, Nimran Kaur, Sabine Kluge, Marcel Konrad, Jamschid Sedighi and Mark Lüdde
Medicina 2025, 61(5), 891; https://doi.org/10.3390/medicina61050891 - 14 May 2025
Viewed by 5596
Abstract
Background and Objectives: Acute myocardial infarction (AMI) is one of the leading causes of mortality worldwide and caused ~1.8 million deaths in the European Union from 2012 to 2020. This study aimed to analyze and quantify sex-based disparities, identifying both clinical and systemic [...] Read more.
Background and Objectives: Acute myocardial infarction (AMI) is one of the leading causes of mortality worldwide and caused ~1.8 million deaths in the European Union from 2012 to 2020. This study aimed to analyze and quantify sex-based disparities, identifying both clinical and systemic contributors to in-hospital mortality differences between male and female patients. Materials and Methods: This multicenter cross-sectional study from 36 hospitals across Germany included all hospitalized patients aged ≥18 years with admissions between January 2019 and December 2023 and a primary diagnosis of AMI. The primary outcome of the study was the prevalence of in-hospital mortality as a function of sex. Multivariable logistic regression analyses were conducted to assess the associations between female sex as compared with male sex and in-hospital mortality. Results: The present study included 9142 male and 4128 female patients with AMI. Women were significantly older than men (74.4 years versus 67.7 years). The proportion of non-ST elevation (NSTE-MI)-MI was higher in women than in men (70.7% versus 66.7%). Overall, in-hospital mortality was higher in women than in men (8.5% versus 7.1%). In a multivariable regression model, female sex was not significantly associated with in-hospital mortality (OR: 0.89; 95% CI: 0.77–1.04) irrespective of the MI type. Conclusions: There were no significant sex-based differences observed in the in-hospital mortality among patients suffering from AMI in Germany. Full article
(This article belongs to the Special Issue Advances in Acute Myocardial Infarction)
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12 pages, 654 KiB  
Article
Exploring the Relationship Between Lipoprotein (a) Level and Myocardial Infarction Risk: An Observational Study
by Ionut Cezar Buciu, Eugen Nicolae Tieranu, Andreea Stefania Pircalabu, Octavian Istratoaie, Ovidiu Mircea Zlatian, Ramona Cioboata, Ionut Donoiu, Constantin Militaru, Sebastian Militaru and Cristian Militaru
Medicina 2024, 60(11), 1878; https://doi.org/10.3390/medicina60111878 - 16 Nov 2024
Cited by 1 | Viewed by 1689
Abstract
Background and Objectives: This observational study investigates the relationship between Lipoprotein (a) (Lp(a)) levels and the risk of acute myocardial infarction (AMI). This study aims to highlight the association of elevated Lipoprotein (a) levels with an increased atherogenic profile and the potential [...] Read more.
Background and Objectives: This observational study investigates the relationship between Lipoprotein (a) (Lp(a)) levels and the risk of acute myocardial infarction (AMI). This study aims to highlight the association of elevated Lipoprotein (a) levels with an increased atherogenic profile and the potential risk of AMI. Materials and Methods: We conducted a case–control study involving 106 individuals, including 64 AMI patients (both STEMI and NSTEMI) and 42 healthy controls. Comprehensive clinical and biochemical assessments, including Lp(a) measurements, were conducted. Results: Patients with Lp(a) levels ≥ 30 mg/dL had a threefold increased risk of AMI compared to those with lower levels, independent of traditional risk factors such as cholesterol, smoking, and body weight. Elevated Lp(a) was observed in 50% of AMI patients compared to 28.57% in controls (p = 0.028). Notably, a multivariate analysis identified high Lp(a) levels, low HDL-C levels, and obesity as significant independent predictors of AMI, indicating these factors may contribute to AMI risk more prominently than other conventional risk factors in patients with elevated Lp(a). Moreover, the association between Lp(a) and AMI risk was consistent across various patient subgroups, with low HDL-C further compounding the risk. Conclusions: Lp(a) is a significant independent risk factor for acute myocardial infarction; therefore, screening for Lp(a) levels can help identify high-risk individuals beyond traditional markers. Therapeutic approaches targeting Lp(a) may reduce AMI incidence. Future research should explore how Lp(a) promotes atherosclerosis and assess Lp(a)-lowering therapies to improve patient outcomes. Full article
(This article belongs to the Special Issue Advances in Acute Myocardial Infarction)
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