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Medicina
Special Issues
New Advances in Oral Care
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New Advances in Oral Care

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 473

Special Issue Editors

Dr. Federica Canfora

E-Mail Website
Guest Editor
Department of Neuroscience, Reproductive Sciences and Dentistry, Oral Medicine Unit, University of Naples Federico II, 80131 Naples, Italy
Interests: oral cancer; orofacial pain; oral surgery; orthodontics
Special Issues, Collections and Topics in MDPI journals
Dr. Daniela Adamo

E-Mail Website
Guest Editor
1. Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 5 Via Pansini, 80131 Naples, Italy
2. Department of Life Sciences, Health, and Health Professions, Link Campus University, 00165 Roma, Italy
Interests: oral cancer; orofacial pain; oral surgery; orthodontics; dental oral and maxillofacial; chronic pain; dental and oral pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral care is undergoing a profound transformation, driven by advances in clinical and translational research, new technologies, and a deeper understanding of the links between oral and systemic health. Beyond traditional preventive and restorative approaches, the field of oral medicine has emerged as a cornerstone for diagnosing and managing complex oral diseases, including mucosal disorders, potentially malignant conditions, salivary gland dysfunctions, and neuropathic pain syndromes. Likewise, orofacial pain represents a growing challenge for both clinicians and patients, requiring multidisciplinary strategies that integrate dentistry, neurology, and pain medicine.

This Special Issue aims to highlight novel perspectives in oral care, oral medicine and orofacial pain. We welcome contributions exploring new diagnostic biomarkers, digital and imaging tools, minimally invasive and regenerative treatments, as well as advances in the understanding and management of new chronic oral conditions. Studies addressing the role of the oral microbiome, systemic comorbidities, and innovative therapeutic approaches—including pharmacological and non-pharmacological interventions—are particularly encouraged.

By bringing together original research and authoritative reviews, this Special Issue seeks to promote innovation, foster interdisciplinary dialogue, and improve patient-centred care in oral health and medicine.

Dr. Federica Canfora
Dr. Daniela Adamo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral health
  • oral diseases
  • preventive dentistry
  • periodontal health
  • orofacial pain

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Published Papers (1 paper)

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Research

20 pages, 5750 KB  
Article
Oral Epithelial Remodeling Associated with Long-Term Contact with Conventional Coronal Dental Amalgam Restorations: A Retrospective Histopathological and Immunohistochemical Study
by Roxana-Cristina Mehedinti, Dorin Ioan Cocoș, Ada Stefanescu, Madalina Nicoleta Matei, Gabriel Valeriu Popa and Dana Tutunaru
Medicina 2026, 62(5), 963; https://doi.org/10.3390/medicina62050963 (registering DOI) - 14 May 2026
Viewed by 143
Abstract
Background and Objectives: Prolonged contact between oral mucosa and dental amalgam restorations may influence local epithelial homeostasis, but the remodeling profile of clinically non-dysplastic mucosa exposed to long-standing amalgam remains insufficiently characterized. This study aimed to evaluate histopathological changes and CK19, Ki67, [...] Read more.
Background and Objectives: Prolonged contact between oral mucosa and dental amalgam restorations may influence local epithelial homeostasis, but the remodeling profile of clinically non-dysplastic mucosa exposed to long-standing amalgam remains insufficiently characterized. This study aimed to evaluate histopathological changes and CK19, Ki67, and p53 expression in the oral mucosa adjacent to long-term amalgam restorations. Materials and Methods: A retrospective observational analysis was performed on 108 oral mucosal specimens, including 78 samples in direct contact with amalgam restorations and 30 non-exposed controls. Exposed cases were grouped according to contact duration: 5–10 years, 11–20 years, and ≥21 years. Histopathological parameters and immunohistochemical expression of CK19, Ki67, and p53 were semi-quantitatively assessed, and an exploratory Integrated Epithelial Remodeling Score was calculated. Results: Longer amalgam exposure was significantly associated with increased inflammatory infiltrate, basal hyperplasia, acanthosis, fibrosis, suprabasal CK19 redistribution, and higher Ki67 labeling indices. The Integrated Epithelial Remodeling Score differed significantly among exposure groups, with higher values in intermediate- and long-duration exposure categories. p53 expression showed statistically detectable but heterogeneous variation. No epithelial dysplasia was observed. Conclusions: Long-term contact with dental amalgam restorations was associated with a coordinated, non-dysplastic remodeling phenotype of the oral mucosa. Given the age imbalance across exposure duration groups, these findings should be interpreted as exposure-associated patterns rather than evidence of a direct causal effect. Because no comparison group exposed to other restorative materials was included, material-specificity for dental amalgam cannot be inferred. In architecturally preserved mucosa, suprabasal CK19 expression may reflect adaptive epithelial plasticity rather than preneoplastic transformation. Full article
(This article belongs to the Special Issue New Advances in Oral Care)
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