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Medicina
Special Issues
Emerging Trends in Head and Neck Surgery
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Emerging Trends in Head and Neck Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 715

Special Issue Editors

Dr. Filippo Carta

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Guest Editor
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, 09100 Cagliari, Italy
Interests: head and neck oncology; laryngology; ear surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Roberto Puxeddu

E-Mail Website
Guest Editor
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, 09100 Cagliari, Italy
Interests: head and neck oncology; laryngology; ear surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Cinzia Mariani

E-Mail Website
Guest Editor Assistant
Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, 09100 Cagliari, Italy
Interests: laryngology; audiology; head and neck oncology

Special Issue Information

Dear Colleagues,

Head and neck surgery encompasses a broad range of surgical procedures addressing pathologies in the head and neck region, including benign and malignant tumours, congenital abnormalities, trauma, infections, and functional disorders.

Since the head and neck region contains vital organs responsible for essential functions such as breathing, eating, smelling and hearing, surgical procedures in this complex area present significant challenges.

For this reason, any innovation that can reduce morbidity while improving both functional and aesthetic outcomes is highly valued.

This Special Issue will focus on recent advances in imaging and endoscopic technologies, minimally invasive surgical approaches, personalized therapeutic strategies, innovations in reconstructive techniques, and the application of artificial intelligence in the diagnosis and treatment planning of head and neck pathologies.

All research aiming to improve the diagnosis and clinical management of pathologies involving the thyroid, parathyroid, salivary glands, larynx, pharynx, oral cavity, nasal cavity, and paranasal sinuses will be considered for publication.

We particularly welcome interdisciplinary contributions that reflect the collaborative nature of modern head and neck surgical care, involving otolaryngologists, radiologists, oncologists, and reconstructive surgeons.

We invite authors to contribute to this Special Issue by sharing their clinical experience with cutting-edge approaches in head and neck surgery.

Authors are welcome to submit original articles, reports on novel treatment strategies and advances in decision making, clinical outcome studies, comparative studies, narrative reviews, scoping reviews and systematic reviews and meta-analyses. We look forward to receiving your manuscripts.

Dr. Filippo Carta
Prof. Dr. Roberto Puxeddu
Guest Editors

Dr. Cinzia Mariani
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck surgery
  • minimally invasive surgical approaches
  • new technologies
  • personalized medicine
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 568 KB  
Article
Microcalcification and Irregular Margins as Key Predictors of Thyroid Cancer: Integrated Analysis of EU-TIRADS, Bethesda, and Histopathology
by Şebnem Çimen, Nazif Zeybek, Adile Begüm Bahçecioğlu, Kerim Bora Yılmaz, Neşe Ersöz Gülçelik and Mehmet Ali Gülçelik
Medicina 2025, 61(12), 2217; https://doi.org/10.3390/medicina61122217 - 16 Dec 2025
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Abstract
Background and Objectives: Thyroid nodules are common, and distinguishing benign from malignant lesions is essential for clinical decision-making. While EU-TIRADS provides ultrasound-based risk stratification, fine-needle aspiration biopsy (FNAB) and the Bethesda System remain central diagnostic tools. This study aimed to compare the diagnostic [...] Read more.
Background and Objectives: Thyroid nodules are common, and distinguishing benign from malignant lesions is essential for clinical decision-making. While EU-TIRADS provides ultrasound-based risk stratification, fine-needle aspiration biopsy (FNAB) and the Bethesda System remain central diagnostic tools. This study aimed to compare the diagnostic performance of EU-TIRADS and Bethesda classifications and to identify ultrasonographic features independently associated with malignancy. Materials and Methods: This retrospective single-center study included 824 patients (1132 nodules) who underwent FNAB between August 2021 and June 2024. All ultrasound examinations and FNAB procedures were performed by the same endocrinologist. Sonographic features, EU-TIRADS categories, Bethesda classes, surgical indications, and histopathology were analyzed. Diagnostic accuracy was assessed using ROC curves, and multivariable logistic regression was applied to determine independent predictors of malignancy. Results: Among all nodules, 51.0% were EU-TIRADS 3, 28.6% were EU-TIRADS 4, and 19.2% were EU-TIRADS 5. Bethesda class II constituted 62.7% of FNAB results. Of the 289 surgically treated nodules, 53.3% were malignant. Malignant nodules were smaller, more often solitary and unilateral, and more frequently located in the upper pole (p < 0.05). Irregular margins (OR = 8.15, p < 0.001) and microcalcifications (OR = 10.01, p = 0.003) were independent predictors of malignancy. Taller-than-wide shape also showed significant association. ROC analyses demonstrated that EU-TIRADS (AUC = 0.808) and Bethesda (AUC = 0.869) were both significant predictors, with Bethesda showing higher specificity. Malignancy rates were 0% in EU-TIRADS II, 4.3% in III, 14.5% in IV, and 37.8% in V. Conclusions: EU-TIRADS is a practical and sensitive non-invasive tool for malignancy risk stratification; however, Bethesda classification remains superior in overall diagnostic accuracy. Microcalcification and irregular margins were the strongest ultrasonographic predictors of malignancy, while macrocalcification, parenchymal heterogeneity, and thyroiditis showed no significant association. These findings support the complementary roles of EU-TIRADS and FNAB and highlight key sonographic markers that enhance malignancy prediction in thyroid nodule evaluation. Full article
(This article belongs to the Special Issue Emerging Trends in Head and Neck Surgery)
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9 pages, 702 KB  
Article
The Use of Microporous Polysaccharide Hemospheres in Thyroid Surgery: A Retrospective Study on Safety and Clinical Outcomes
by Cinzia Mariani, Amina Al Dababsekh, Filippo Carta, Mauro Bontempi, Carmelo Barbaccia and Roberto Puxeddu
Medicina 2025, 61(12), 2209; https://doi.org/10.3390/medicina61122209 - 15 Dec 2025
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Abstract
Background and Objectives: Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic powder, is designed to enhance intraoperative bleeding control. The present study evaluates the efficacy and [...] Read more.
Background and Objectives: Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic powder, is designed to enhance intraoperative bleeding control. The present study evaluates the efficacy and safety of Arista™ AH in thyroidectomy. Materials and Methods: This retrospective study included 102 patients who underwent thyroidectomy between January 2020 and February 2024. Of these, 63 patients (61.8%) received Arista™ AH as an adjunctive hemostatic agent, and 39 (38.2%) underwent only conventional hemostasis. Outcomes measured included the incidence of postoperative hematoma and seroma, adverse events related to the use of Arista™ AH, and length of hospital stay. Results: None of the patients in the Arista™ AH group developed a hematoma in the thyroid surgical bed, whereas this complication occurred in 2 patients (5.1%) of the control group (p = 0.07). No patients in the Arista™ AH group developed a postoperative seroma, compared with 2 patients (5.1%) in the control group (p = 0.07). No adverse events related to Arista™ AH were reported. Length of hospital stay was similar between groups, with a median of 2 days (IQR 1) in both the Arista™ AH and control groups (p = 0.8). Conclusions: Arista™ AH was associated with favorable postoperative outcomes in thyroid surgery, supporting its safe and effective use as a hemostatic adjunct. Full article
(This article belongs to the Special Issue Emerging Trends in Head and Neck Surgery)
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