Recent Advances in Metabolic Syndrome and Its Comorbidities: The Scourge of the 21st Century
A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Endocrinology".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1019
Special Issue Editors
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Special Issue Information
Dear Colleagues,
It is a reality that the dramatic expansion of the Western lifestyle—physical inactivity, increased consumption of high-fat diets and processed food, and smoking and the consumption of alcoholic beverages—attenuates the incidence of metabolic syndrome (MS) globally. MS and obesity will constitute a third global crisis in parallel with the pandemic of malnutrition and the climate crisis. MS is a complex of hyperglycemia, obesity (central obesity), high blood pressure, low high-density lipoprotein cholesterol (HDL-C), and elevated triglyceride levels. Patients with MS are at risk for developing cardiovascular (CV) and chronic kidney disease (CKD). Central obesity, a phenotypic characteristic of MS, indicates metabolic dysfunction-associated steatotic liver disease (MASLD) and this puts patients at additional risk of CV events, as well as an increased incidence for steatohepatitis, cirrhosis, hepatocellular carcinoma, and extrahepatic neoplasms. The gut–liver axis also plays an essential role in the metabolism’s regulation and development of MASLD. Furthermore, the coexistence of MS with polycystic ovary syndrome (PCOS) requires surveillance for hypogonadism and lessened fertility. Weight loss through regular exercise and a healthy diet constitutes the cornerstone of combating MS; however, this is not always possible. Hence, novel therapies targeting weight loss, euglycemia, and steatotic liver disease come to the fore.
The aim of this Special Issue is to gather together up-to-date scientific evidence on the management of metabolic syndrome and its components, with particular reference to pathophysiological pathways, diagnostic implications, clinical management, and precision medicine. We are pleased to invite you and your co-workers to submit your original research and review articles on this topic.
Dr. Eleni Geladari
Dr. Vassilios Sevastianos
Guest Editors
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Keywords
- metabolic syndrome
- hypertension
- diabetes mellitus
- dyslipidemia
- cardiovascular disease
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- chronic kidney disease
- hypogonadism
- hepatocellular carcinoma
- extrahepatic neoplasms
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