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Oral and Maxillofacial Surgery: Current Trends, Therapeutic Approaches and Future...
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Oral and Maxillofacial Surgery: Current Trends, Therapeutic Approaches and Future Directions

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry and Oral Health".

Deadline for manuscript submissions: 15 August 2026 | Viewed by 2011

Special Issue Editors

Prof. Dr. Μaria N. Kantzanou

E-Mail Website
Guest Editor
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece
Interests: epidemiology; microbiology; prognostics factors; patient-reported outcome measures; clinical pharmacology; oral and craniofacial infections; surgical sites infections; molecular diagnostics
Dr. Evangelos Kostares

E-Mail Website
Guest Editor Assistant
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece
Interests: oral and maxillofacial surgery; dentistry; head and neck surgery; postoperative complications; epidemiology; meta-analysis; evidence synthesis

Special Issue Information

Dear Colleagues,

Oral and maxillofacial surgery (OMFS) has experienced remarkable progress over recent decades, evolving into a multidisciplinary specialty that integrates clinical expertise, advanced technology, and scientific innovation. This Special Issue, titled “Oral and Maxillofacial Surgery: Current trends, Therapeutic Approaches and Future Directions,” aims to provide a comprehensive overview of the current status of the field, including both established and emerging treatment modalities. It will encompass the full spectrum of OMFS, such as trauma management, orthognathic and reconstructive surgery, implantology, oral oncology, and esthetic interventions, emphasizing evidence-based and patient-centered care. In addition to clinical and technological advances, this Special Issue seeks to explore under-researched areas in epidemiological data to improve understanding of disease patterns, treatment outcomes, and population-level trends. Cutting-edge research topics will include current treatments as well as artificial intelligence, 3D printing, virtual surgical planning, robotic-assisted techniques, regenerative medicine, and novel biomaterials that are reshaping surgical practice. By fostering the exchange of high-quality scientific evidence and promoting interdisciplinary collaboration, this Special Issue aims to highlight innovations, improve global knowledge dissemination, and define future priorities in oral and maxillofacial surgery. We welcome submissions of original research, observational and interventional studies, systematic reviews, meta-analyses, and comprehensive review articles focusing on clinical innovation, epidemiological insights, and future directions in oral and maxillofacial surgery.

Dr. Μaria N. Kantzanou
Guest Editor

Dr. Evangelos Kostares
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral and maxillofacial
  • reconstructive surgery
  • orthognathic surgery
  • dental implants and bone regeneration
  • minimally invasive techniques
  • 3D printing and surgical planning
  • artificial intelligence and digital technologies
  • oral and maxillofacial oncology
  • epidemiology
  • evidence-based clinical practice

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Published Papers (2 papers)

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Research

12 pages, 2370 KB  
Article
An Analysis of Mandibular Characteristics According to Biological Sex Using Three-Dimensional Computed Tomography Scans in Koreans: A Retrospective and Observatoinal Study
by Byeongjun Kim, Junghyun Lee, Donghyun Lee, Kuylhee Kim, Jiwon Jeong and Soyeon Jung
Medicina 2026, 62(2), 398; https://doi.org/10.3390/medicina62020398 - 19 Feb 2026
Viewed by 748
Abstract
Background and Objectives: With the increasing demand for gender-affirming procedures, facial feminization surgery (FFS) has become an essential component in the management of patients with gender dysphoria. In this study, ‘male’ and ‘female’ refer to biological sex as recorded in the medical [...] Read more.
Background and Objectives: With the increasing demand for gender-affirming procedures, facial feminization surgery (FFS) has become an essential component in the management of patients with gender dysphoria. In this study, ‘male’ and ‘female’ refer to biological sex as recorded in the medical record; gender identity was not assessed. The mandible is widely recognized as one of the most sexually dimorphic facial bones and plays a critical role in defining masculine and feminine facial contours. However, quantitative mandibular data directly applicable to surgical planning for FFS, particularly in Asian populations, remain limited. The purpose of this study was to analyze gender differences in mandibular morphology using three-dimensional (3D) computed tomography (CT) images and to provide clinically relevant anatomic data applicable to mandibular contouring in FFS. Materials and Methods: In this single-center retrospective study, 275 Korean patients who underwent facial CT between January 2017 and December 2019 were enrolled. Three-dimensional cephalometric analysis was performed to obtain surgically relevant mandibular measurements, including angular, linear, and transverse parameters, as well as non-metric characteristics such as chin shape and inferior mandibular border contour. Statistical comparisons were conducted to evaluate gender differences. Results: Significant gender differences were observed in mandibular angle (p < 0.001), mandible length (p < 0.001), antegonial notch distance (p < 0.001), intercondylar width (p < 0.001), and intergonial width (p < 0.001). Ramus length and chin width did not demonstrate statistically significant differences. Non-metric analysis revealed significant gender differences in chin morphology and inferior mandibular border contour (p < 0.01). Males predominantly exhibited a round or square chin (79.5%) and a rocker-shaped inferior border, whereas females commonly demonstrated a pointed chin (82.3%) and a straight inferior mandibular border (94.4%). Conclusions: The sexual dimorphism of the mandible in the Korean population is characterized by differences in angularity, transverse width, antegonial morphology, and inferior border contour. These findings provide population-specific morphological reference ranges that may support individualized preoperative assessment for mandibular contouring in facial feminization surgery. Full article
(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Current Trends, Therapeutic Approaches and Future Directions)
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12 pages, 711 KB  
Article
Complications Following Karapandzic Flap Reconstruction of the Lip: A Retrospective Cohort Study
by Evangelos Kostares, Michael Kostares, Georgia Kostare, Vasiliki Koumaki, Kalliopi Theodoridou, Stefanos Korfias, Georgia Vrioni, Stavros Vassiliou, Konstantinos Kontos, Christos Makos, Athanasios Tsakris and Maria Kantzanou
Medicina 2026, 62(1), 12; https://doi.org/10.3390/medicina62010012 - 20 Dec 2025
Cited by 1 | Viewed by 692
Abstract
Background and Objectives: Squamous cell carcinoma (SCC) of the lip is a common malignancy of the oral and maxillofacial region. Medium-to-large post-excisional defects often require reconstructive techniques that preserve oral competence, function, and facial aesthetics. Despite its broad clinical use, the Karapandzic [...] Read more.
Background and Objectives: Squamous cell carcinoma (SCC) of the lip is a common malignancy of the oral and maxillofacial region. Medium-to-large post-excisional defects often require reconstructive techniques that preserve oral competence, function, and facial aesthetics. Despite its broad clinical use, the Karapandzic flap lacks comprehensive evidence describing its postoperative outcomes and associated complications. Materials and Methods: This retrospective cohort study evaluated all consecutive patients who underwent lip SCC excision followed by Karapandzic flap reconstruction at a tertiary oncologic center in Greece from 2000 to 2024. Demographic, clinical, pathological, and postoperative data were collected, and complications were categorized as early (wound dehiscence, surgical site infection, hematoma) or late (microstomia, excessive scarring). Statistical analyses included comparative tests and Firth’s logistic regression to explore potential predictors of morbidity. Results: A total of 102 patients met the inclusion criteria. Most were male (82.4%) with a median age of 68.8 years, and 94.1% had lower-lip tumors. Early complications occurred in 9.8% of patients and late complications in 17.7%, with microstomia being the most frequent late event (15.7%). Age was the only variable showing a borderline significant association with overall complications. No demographic, clinical, or pathological factor, including lesion morphology, cytological diagnosis, tumor location, or presence of metastasis, demonstrated a statistically significant association with early or late complications. Conclusions: Karapandzic flap reconstruction represents a reliable single-stage option for lip SCC defects, demonstrating relatively low complication frequencies and generally favorable functional outcomes. Further comparative studies are warranted to evaluate its performance relative to alternative reconstructive techniques. Full article
(This article belongs to the Special Issue Oral and Maxillofacial Surgery: Current Trends, Therapeutic Approaches and Future Directions)
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