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Resorbable and Nonresorbable Materials for Medical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 1967

Special Issue Editor


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Guest Editor
Department of Biomedical Science and Neuromotor Sciences (DIBINEM), University of Bologna, Via San Vitale 59, 40125 Bologna, Italy
Interests: bone augmentation; guided bone regeneration; digital dentistry; biomaterials

Special Issue Information

Dear Colleagues,

Resorbable and nonresorbable materials have been used to repair defects in a clinical setting, which has led to the development of a wide variety of materials for specific therapeutic purposes. The efficiency in the repair of the defect and the safety of the different used materials are determined not only by the anatomical site where they are located but also by the nature and structure of their components. These materials range from natural polymers and materials of biological origin which are designed to be resorbed inside the body, to metallic and synthetic materials which need to be removed after their function is served. Their importance is essential for other elements, such as the composition of different bone substitutes that can be used which can be either derived from biological products such as demineralized bone matrix, platelet-rich plasma, adjunction of growth factors or synthetic such as calcium sulfate, tri-calcium phosphate ceramics, or polymer-based substitutes. These substitutes must be chosen selectively depending on their clinical use which include but are not limited to spine fusion, open-wedge tibial osteotomy, long bone fracture, oral and maxillofacial surgery, or periodontal treatments.

This Special Issue is dedicated to any resorbable and non-resorbable material which is used for medical applications and where the use of these elements is key in accelerating the healing process and repairing damage and defects.

Dr. Alessandro Cucchi
Guest Editor

Manuscript Submission Information

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Keywords

  • bone augmentation
  • guided bone regeneration
  • digital dentistry
  • biomaterials

Published Papers (1 paper)

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Research

8 pages, 5137 KiB  
Article
Effect of BMP-2 Adherent to Resorbable Sutures on Cartilage Repair: A Rat Model of Xyphoid Process
by Nathan Drummond, Bradley W. Bruner, Michael H. Heggeness, Bradley Dart and Shang-You Yang
Materials 2020, 13(17), 3764; https://doi.org/10.3390/ma13173764 - 26 Aug 2020
Cited by 2 | Viewed by 1563
Abstract
Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects of Bone morphogenetic protein-2 (BMP-2) soaked sutures for cartilage repair, [...] Read more.
Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects of Bone morphogenetic protein-2 (BMP-2) soaked sutures for cartilage repair, using a rat model of xyphoid healing. Vicryl-resorbable sutures were presoaked in BMP-2 solutions prior to animal experimentation. Rat xyphoid process (an avascular hyaline cartilage structure) was surgically ruptured followed by repair procedures with regular suture or with sutures that were pre-soaked in BMP-2 solutions. In vitro assessment indicated that presoaking the Vicryl-resorbable sutures with 10 µg/mL BMP-2 resulted in a sustained amount of the growth factor release up to 7 days. Histological analysis suggested that application of this BMP-2 soaked suture on the rat xyphoid process model significantly improved the avascular cartilage healing compared to non-soaked control sutures. In conclusion, data here confirm that the rat xyphoid process repair is a reproducible and inexpensive animal model for meniscus and other cartilage repair. More importantly, coating of BMP-2 on sutures appears a potential avenue to improve cartilage repair and regeneration. Further study is warranted to explore the molecular mechanisms of this strategy. Full article
(This article belongs to the Special Issue Resorbable and Nonresorbable Materials for Medical Applications)
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