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Effects of Bone Substitute Materials in Bone Defect Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 October 2023) | Viewed by 1530

Special Issue Editor


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Guest Editor
SCU · Department of Chemical Engineering, Sichuan University, Chengdu, China
Interests: tissue-inducing biomaterials

Special Issue Information

Dear Colleagues,

With the development of regenerative medicine, traditional biomaterials can no longer meet clinical needs. Current developments in the field are focused on endowing biomaterials with specific structure and biological functions which can stimulate the specific response of the body, mobilize the self-improvement and rehabilitation function of the human body, and realize the regeneration and reconstruction of human tissues or organs. This discovery of osteoinducion indicates that materials might be endowed with the biofunction of inducing tissue regeneration, and thus are hopeful for realizing the establishment of tissue function through material design.

This Special Issue will focus on the development of bioactive materials for bone regeneration. The Special Issue topics of interest include, but are not limited to:

  • Fabrication methods of bone substitutes;
  • Surface modification of bone substitutes;
  • Evaluation of chemical and physical properties of bone substitutes;
  • Specific effects of biomaterial characteristics on osteogenesis.

Dr. Xiangfeng Li
Guest Editor

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Keywords

  • bone defect
  • biomaterials
  • osteoinduction
  • material characteristics
  • fabrication methods
  • surface modification
  • bone regeneration

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Published Papers (1 paper)

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Research

14 pages, 33142 KiB  
Article
Histological Comparison of Collagenated Cancellous Equine Bone Blocks Used as Inlay or Onlay for Lateral Bone Augmentation in Rabbits
by Ryuichi Sakaguchi, Samuel Porfirio Xavier, Kenzo Morinaga, Daniele Botticelli, Erick Ricardo Silva, Yasushi Nakajima and Shunsuke Baba
Materials 2023, 16(20), 6742; https://doi.org/10.3390/ma16206742 - 18 Oct 2023
Cited by 2 | Viewed by 1235
Abstract
Background: The conformation of the recipient site for an inlay graft presents an increased contact with the parent bone compared to an onlay graft. This might favor bone growth within the inlay compared to onlay grafts. Hence, the objective of this study was [...] Read more.
Background: The conformation of the recipient site for an inlay graft presents an increased contact with the parent bone compared to an onlay graft. This might favor bone growth within the inlay compared to onlay grafts. Hence, the objective of this study was to compare the bone incorporation and remodeling processes of xenogeneic en bloc grafts placed using two bone grafting techniques, i.e., onlay vs. inlay. Methods: In this prospective, randomized, split-mouth study (test and control sides in the same animal), two bone grafting techniques were comparatively evaluated. The lateral aspect of the rabbit mandible was used as the recipient site, bilaterally. On one side of the mandible, the cortical bone was perforated with drills to allow a better bone formation from the bone wound and the marrow spaces. A xenogeneic bone block was fixed in the center of the prepared region, representing the onlay site. On the other side of the mandible, a 7 mm wide and 3 mm deep circumferential defect was prepared using trephines and drills. A xenogeneic bone block was fixed in the center of the defect, representing the inlay site. Two healing periods were applied in the study: 2 and 10 weeks, each represented by 10 rabbits (n = 10 for each period). Results: After 2 weeks of healing, the mean percentage of new bone was 10.4% and 23.3% at the onlay and inlay grafts, respectively (p = 0.022). After 10 weeks of healing, new bone increased to 13.2% at the onlay sites and 25.4% at the inlay sites (p = 0.080). In the 10-week period, the inlay grafts presented a homogeneous growth of new bone in all regions, while in the onlay grafts, low percentages of new bone were observed in the external regions. Conclusion: The percentage of new bone increased faster and was higher in the inlay grafts than in the onlay grafts. This outcome might be related to the self-contained conformation of the recipient site in the inlay group, which offered more sources for new bone formation compared to the one-wall conformation of the recipient sites in the onlay group. The osteoconductive properties of the biomaterial allowed the newly formed bone to reach the most peripheral regions in both groups. The osteoconductive properties of the biomaterial, together with the protection offered by the collagen membrane, allowed marginal closure of the defects by newly formed bone in the inlay group. Full article
(This article belongs to the Special Issue Effects of Bone Substitute Materials in Bone Defect Regeneration)
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