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Interaction Between Biomaterials and Biological Systems

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1073

Special Issue Editor


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Guest Editor
College of Materials Sciences and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Interests: nanomedicine; immunotherapy; drug delivery; hydrogel; nanoparticle; metabolism; adipose; antioxidants

Special Issue Information

Dear Colleagues,

Biomaterials currently have enormous importance in biomedicine, including biomedical devices, tissue engineering implants, drug delivery systems, and antibacterial material. Biomaterial–cell and biomaterial–tissue interactions in implant materials represent key issues to address in both initial and long-term implant integration. An understanding of these interactions will guide structural design and surface modification in biomaterials. With this Special Issue, we hope to inspire researchers and academics to explore the interactions between biomaterials and various biological systems and contribute to the design, development, application, and evaluation of biomaterials.

For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Immune response to implants;
  • Soft tissue management around implants;
  • Cell incorporation in three-dimensional scaffolds;
  • Interactions between nanomaterials and cells and tissues;
  • Bacteria–surface interactions.

Prof. Dr. Jimin Guo
Guest Editor

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Keywords

  • biomaterials
  • implants
  • three-dimensional scaffolds
  • nanoparticles
  • immune response
  • tissue–biomaterial interaction
  • cell–biomaterial interaction
  • bacterium–biomaterial interaction
  • structural design
  • surface modification

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Published Papers (1 paper)

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Research

20 pages, 6160 KB  
Article
The Impact of Physical Form on the Biocompatibility of Poly(3-hexylthiophene-2,5-diyl)
by Daniela A. Tudor, Sorin David, Mihaela Gheorghiu and Szilveszter Gáspár
Materials 2025, 18(20), 4671; https://doi.org/10.3390/ma18204671 - 11 Oct 2025
Viewed by 338
Abstract
Poly(3-hexylthiophene-2,5-diyl) (P3HT) is a semiconducting, electron donor polymer which, in addition to its intensive use in optoelectronic devices, is increasingly investigated in biological systems. However, there are conflicting reports about the biocompatibility of P3HT, and no direct comparison between P3HT films and P3HT [...] Read more.
Poly(3-hexylthiophene-2,5-diyl) (P3HT) is a semiconducting, electron donor polymer which, in addition to its intensive use in optoelectronic devices, is increasingly investigated in biological systems. However, there are conflicting reports about the biocompatibility of P3HT, and no direct comparison between P3HT films and P3HT nanoparticles has been conducted. In this context, we investigated the viability of bEnd.3 endothelial cells when such cells are grown onto P3HT films or incubated with P3HT nanoparticles and subjected to trains of moderate power density, relatively long light pulses. We observed that, while P3HT films do not decrease the viability of bEnd.3 cells at all, P3HT nanoparticles lower the viability of bEND.3 cells by ~20%, when the nanoparticles also contain [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) as electron acceptor, and by ~30%, when the nanoparticles do not contain PCBM. Interestingly, the used photoexcitation protocol did not impact the biocompatibility of the P3HT-based materials. The obtained results reveal that (i). nanostructuring has a detrimental impact on the compatibility of P3HT with bEND.3 endothelial cells, and (ii). P3HT-based materials can be safely combined with light when used in biological systems because light, as used in the present study, does not alter the biocompatibility of such materials. Full article
(This article belongs to the Special Issue Interaction Between Biomaterials and Biological Systems)
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