materials-logo

Journal Browser

Journal Browser

3D Tissue Models and Biomaterials for Oral Soft Tissue Regeneration

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 431

Special Issue Editors


E-Mail Website
Guest Editor
Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, USA
Interests: biomaterials; tissue engineering; bioprinting; 3D tissue models; microencapsulation

E-Mail Website
Guest Editor
Department of Comprehensive Dentistry, University of Maryland School of Dentistry, 650 W. Baltimore St, Baltimore, MD 21201, USA
Interests: bio fabrication; 3D printing; electrospinning; tissue engineering; dentistry

Special Issue Information

Dear Colleagues,

The development of 3D Tissue Models and Biomaterials for Oral Soft Tissue Regeneration has become a promising area of research in the regenerative medicine field. These innovative approaches aim to provide solutions for repairing and replacing damaged oral soft tissues, such as gums and mucosa, which are often affected by various oral diseases and injuries.

By utilizing advanced techniques such as 3D bioprinting and tissue engineering, researchers are able to create complex and functional tissue models that closely mimic the structure and function of natural oral soft tissues. Biomaterials play a crucial role in these tissue regeneration strategies, as they provide a scaffold for cell growth and tissue formation. These materials can be designed to have specific properties, such as biocompatibility, biodegradability, and mechanical strength, essential for promoting tissue regeneration and integration in the oral environment. By mimicking the structure and function of natural oral tissues, these models and materials offer promising solutions for improving oral soft tissue regeneration procedures and developing personalized therapies for patients in need.

Dr. Maedeh Rahimnejad
Dr. Nileshkumar Dubey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D tissue models
  • biomaterials
  • oral soft tissue regeneration
  • regenerative medicine
  • tissue engineering
  • 3D bioprinting
  • scaffold
  • biocompatibility

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

13 pages, 2614 KiB  
Article
Rheological Investigation of Polydimethylsiloxane with Glass Beads: A Model for Compression-Stiffening Effects in Soft Tissue Engineering
by Dawid Łysik and Joanna Mystkowska
Materials 2025, 18(7), 1663; https://doi.org/10.3390/ma18071663 - 4 Apr 2025
Viewed by 220
Abstract
This study explores the rheological properties of polydimethylsiloxane (PDMS) composites with glass beads (GBs) to replicate the compression-stiffening behavior of biological tissues. The mechanical properties of soft tissues arise from interactions between the extracellular matrix (ECM) and embedded cells. To mimic this, PDMS [...] Read more.
This study explores the rheological properties of polydimethylsiloxane (PDMS) composites with glass beads (GBs) to replicate the compression-stiffening behavior of biological tissues. The mechanical properties of soft tissues arise from interactions between the extracellular matrix (ECM) and embedded cells. To mimic this, PDMS was used as a polymeric matrix, while rigid GBs acted as non-deformable inclusions facilitating stress redistribution. PDMS composites with 10%, 20%, and 30% GB concentrations were fabricated. Rheological analysis revealed that GBs significantly enhanced the storage modulus (G′), with stiffness increasing linearly under compression. The stiffening rate rose from 300 Pa/% (pure PDMS) to 387 Pa/%, 836 Pa/%, and 2035 Pa/% for 10%, 20%, and 30% GB, respectively, marking a sevenfold increase at the highest concentration. Similarly, the apparent Young’s modulus increased from 150 kPa (pure PDMS) to 200 kPa, 300 kPa, and 380 kPa for composites with 10%, 20%, and 30% GB, respectively. PDMS-GB composites successfully reproduce the compression-stiffening effect observed in biological tissues, which may aid research in mechanobiology and tissue engineering. Full article
(This article belongs to the Special Issue 3D Tissue Models and Biomaterials for Oral Soft Tissue Regeneration)
Show Figures

Figure 1

Back to TopTop