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Properties and Applications of Oral Implant Biomaterials
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Properties and Applications of Oral Implant Biomaterials

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 2330

Special Issue Editors

Dr. Luca Lamazza

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Guest Editor
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy
Interests: oral medicine; oral surgery; oral implantology; bone regeneration
Special Issues, Collections and Topics in MDPI journals
Dr. Alberto De Biase

E-Mail Website
Guest Editor
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy
Interests: oral and maxillo facial surgery; oral implantology; guided bone regeneration; platelet concentrates; dentin grafts
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Lollobrigida

E-Mail Website
Guest Editor
Department of Oral Sciences and Maxillofacial Surgery, Sapienza University of Rome, 00161 Rome, Italy
Interests: oral surgery; oral implantology; guided bone regeneration; implant surfaces; perimplantitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue on "Properties and Applications of Oral Implant Biomaterials". The development and refinement of biomaterials for oral implants are crucial for advancing dental treatments and enhancing patient outcomes. This field focuses on creating materials that not only integrate seamlessly with oral tissues but also withstand the mechanical demands of the oral environment.

This Special Issue aims to present the latest research and advancements in the properties, fabrication techniques, and applications of biomaterials used in oral implantology. The scope of this Special Issue includes studies on biocompatibility, mechanical strength, surface modifications, and bioactivity of various materials tailored for oral implants. We welcome submissions that provide insights into innovative materials, advanced processing methods, and clinical performance evaluations.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Development and characterization of new biomaterials for oral implants including bone substitutes and platelet concentrates;
  • Surface modification and coating techniques for enhanced biocompatibility and bioactivity in the oral environment;
  • Mechanical properties and wear resistance of oral implant materials;
  • Smart and multifunctional biomaterials for dental applications;
  • Clinical applications and case studies of oral implant biomaterials;
  • Biodegradable and bioresorbable materials for temporary dental implants.

We look forward to receiving your contributions.

Dr. Luca Lamazza
Dr. Alberto De Biase
Dr. Marco Lollobrigida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental implants
  • biocompatibility
  • surface modification
  • bioactivity
  • smart biomaterials
  • bone substitutes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

12 pages, 1322 KiB  
Article
Advanced Platelet-Rich Fibrin (A-PRF) as Antibiotics Delivery System: In-Vitro Proof-of-Concept Study
by Giorgio Serafini, Alessia Mariano, Marco Lollobrigida, Luca Lamazza, Giulia Mazzucchi, Patrizia Spigaglia, Fabrizio Barbanti, Anna Scotto d’Abusco and Alberto De Biase
Materials 2025, 18(3), 570; https://doi.org/10.3390/ma18030570 - 27 Jan 2025
Cited by 1 | Viewed by 972
Abstract
Autologous blood centrifugation produces various forms of platelet concentrates widely used in tissue regenerative therapies due to their high concentrations of growth factors and abundance of autologous cells. Advanced Platelet-Rich Fibrin (A-PRF), introduced as a low-speed centrifugation product, contains an even higher concentration [...] Read more.
Autologous blood centrifugation produces various forms of platelet concentrates widely used in tissue regenerative therapies due to their high concentrations of growth factors and abundance of autologous cells. Advanced Platelet-Rich Fibrin (A-PRF), introduced as a low-speed centrifugation product, contains an even higher concentration of growth factors, a greater number of cells, and a looser fibrin clot structure compared to previous Leukocyte and Platelet-Rich Fibrin (L-PRF). This study aims to assess the potential of A-PRF as a local delivery system for antibiotics. Different concentrations (0.5 mg/mL, 0.25 mg/mL, and 0.125 mg/mL) of injectable amoxicillin (AMX) and metronidazole (MTZ) were preliminarily tested for their impact on A-PRF clot formation, with 0.5 mg/mL selected for subsequent experiments. Blood samples from healthy volunteers were supplemented with antibiotics and centrifuged to form clots. Antibiotic-enriched A-PRF clots were immersed in phosphate-buffered saline (1x PBS) and analyzed at 24 h, 72 h, 7 days, and 14 days. AMX showed a consistent release (mean: 19.9 ± 4.8 ng/mL at 24 h) over 14 days, while MTZ demonstrated greater variability (mean: 12.8 ± 4.5 ng/mL at 24 h). AMX release remained constant over the 14-day period, with no significant variations among patients. In contrast, MTZ displayed a progressively lower release over time. Microbiological analysis revealed bacterial growth inhibition zones for Fusobacterium nucleatum (AMX: 23 mm, MTZ: 28 mm) and Prevotella intermedia (AMX: 34 mm, MTZ: 30 mm) at 24 h. These findings suggest that A-PRF can act as an effective local antibiotic delivery system, maintaining sustained antimicrobial activity and potentially reducing the need for systemic antibiotics. Full article
(This article belongs to the Special Issue Properties and Applications of Oral Implant Biomaterials)
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15 pages, 2936 KiB  
Article
The Effects of Light Crystal Display 3D Printers, Storage Time and Steam Sterilization on the Dimensional Stability of a Photopolymer Resin for Surgical Guides: An In Vitro Study
by Nicola Pranno, Alessio Franchina, Francesca De Angelis, Maurizio Bossù, Alessandro Salucci, Edoardo Brauner, Maria Paola Cristalli and Gerardo La Monaca
Materials 2025, 18(3), 474; https://doi.org/10.3390/ma18030474 - 21 Jan 2025
Viewed by 801
Abstract
Background: Implant surgical guides manufactured in-house using 3D printing technology are widely used in clinical practice to translate virtual planning to the operative field. Aim: The present in vitro study investigated the dimensional changes of 3D surgical guides printed in-house using Shining 3D [...] Read more.
Background: Implant surgical guides manufactured in-house using 3D printing technology are widely used in clinical practice to translate virtual planning to the operative field. Aim: The present in vitro study investigated the dimensional changes of 3D surgical guides printed in-house using Shining 3D surgical guide resin (SG01). Materials and methods: Five test bodies, varying in shape and dimensions, were designed using computer-aided design (CAD) software and manufactured using three different Light Crystal Display (LCD) 3D printers (AccuFab-L4D, Elegoo Mars Pro 3, and Zortrax Inspire). Specific printing and post-processing parameters for the SG01 resin were set to produce 25 test bodies (5 of each shape) from each of the three printers, resulting in a total of 75 samples. The dimensional changes were evaluated using a digital calliper at four different time points: immediately after printing (T0), one month after storage (T1), immediately after sterilization (T2), and one month after sterilization (T3). Results: All the test bodies showed deviations from the overall CAD reference value of 12.25 mm after printing and post-processing (T0) and following steam sterilization (T2). Similar trends were observed for the effect of storage times at T1 and T3. The AccuFab prints demonstrated a better dimensional stability than the Elegoo and Zortrax samples. Conclusions: The LCD 3D printers, sterilization, and storage times influenced the dimensional stability of the test bodies made with SGO1 resin. Full article
(This article belongs to the Special Issue Properties and Applications of Oral Implant Biomaterials)
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