Biomaterials and Scaffolds for Enhanced Production of Exosomes and Accelerated Tissue Repair and Regeneration
A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".
Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 2386
Special Issue Editor
Interests: biomaterials; bone bioengineering; stem cells; biomaterials for tissue engineering; advanced bioceramics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Exosomes are nano-sized extracellular vesicles (EVs) that contain various therapeutic components (protein, DNA, and RNA). In response to various cues (e.g., pharmaceuticals), human cells release exosomes into the surrounding physiological fluids which are subsequently taken up by neighboring or distant cells. The released exosomes can reprogram the recipient cells in specific pathways. For example, exosomes may lead to triggering biological phenomena such as the overexpression of pro-angiogenic proteins (e.g., vascular endothelial growth factor (VEGF). In the concept of tissue engineering and regenerative medicine, exosomes can be utilized as potent tools for the acceleration of the wound healing process. Therefore, several innovative approaches and strategies, including the use of biomaterials and scaffolds, have been developed and applied in order to derive cells to secrete exosomes with particular cargoes. As an illustration, bioactive glasses and glass-ceramics can significantly stimulate mesenchymal stem cells (MSCs) to secrete exosomes containing low levels of miR-342-5p and high amounts of miR-1290, which in turn induces endothelial cells (ECs) vascularization and intradermal angiogenesis. The present Special Issue aims to provide an invaluable collection of contributions and a platform for a scientific discussion focused on the role of biomaterials and scaffolds in enhancing exosomes’ secreting and subsequent accelerated tissue repair and regeneration. Original research papers and reviews are welcome in this Special Issue, the key topics of which include (but are not limited to) biomaterials, exosomes, stem cells, cell signaling, and tissue engineering. We look forward to receiving your contributions.
Dr. Saeid Kargozar
Guest Editor
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Keywords
- biomaterials
- scaffolds
- exosomes
- extracellular vesicles
- stem cells
- cell signaling
- wound healing
- tissue engineering
