Bioactivity of New Biomaterials
A Special Issue of Materials (ISSN 1996-1944) belonging to the section "Biomaterials".
Deadline for manuscript submissions: 20 December 2026 | Viewed by 157
Editors
Interests: biomaterials surface analysis; quantitative surface characterization; atomic force microscopy (AFM); confocal microscopy; biocompatibility; surface topography modeling; implant surface modification
Special Issues, Collections and Topics in MDPI journals
Interests: advanced biomedical materials; polymeric membranes for extracorporeal devices; hemocompatibility; antimicrobial nanocomposites; silver nanoparticles; surface modification; molecular diagnostics
Special Issues, Collections and Topics in MDPI journals
Interests: biomaterials surface analysis; quantitative surface characterization; surface topography; atomic force microscopy (AFM); biocompatibility; biomaterial–tissue interfaces
Special Issue Information
Dear Colleagues,
Bioactivity of new biomaterials is at the forefront of materials science and biomedical engineering, driven by the urgent need for next-generation implants, scaffolds, and medical devices that interact with living tissues in a controlled, predictable manner. As global demand for surgical implants and tissue engineering constructs continues to grow—fuelled by ageing populations, rising incidence of chronic diseases, and advances in regenerative medicine—the development of biomaterials with tailored surface properties and optimal biological response has become a central challenge for the scientific community. Surface chemistry, topography, and microstructure are the primary determinants of how a biomaterial interacts with proteins, cells, and host tissues, and small changes in these parameters can profoundly alter osseointegration, soft tissue adhesion, and the local immune response.
Progress in this area requires both advanced experimental characterisation techniques—including atomic force microscopy (AFM), confocal laser scanning microscopy, high-resolution X-ray computed microtomography, and spectroscopic methods—and computational modelling approaches that allow prediction of biomaterial behaviour in physiological environments before clinical translation. Equally important is the close collaboration between materials scientists, biomedical engineers, and medical practitioners, which ensures that novel materials address real clinical problems and meet stringent regulatory requirements.
This Special Issue aims to present and disseminate the most recent advances related to the design, synthesis, characterisation, and biological evaluation of new biomaterials. We consider contributions addressing the full spectrum of bioactivity research: from the molecular-level understanding of surface–protein and surface–cell interactions, through in vitro and in vivo assessment of biocompatibility, to the engineering of surface modifications that enhance osseointegration, tissue regeneration, or antimicrobial performance. Particular attention is given to quantitative, standardised methods of surface analysis and to data-driven approaches—including machine learning and computer modelling—that support the rational design of bioactive materials.
Topics of interest for publication include, but are not limited to, the following:
- Surface modification strategies for enhanced biocompatibility and bioactivity;
- Quantitative characterisation of biomaterial surfaces (roughness, topography, porosity);
- Protein adsorption and cell adhesion at biomaterial–tissue interfaces;
- Bioactive coatings for metallic, ceramic, and polymeric implants;
- Osteoconductive and osteoinductive biomaterials;
- Antimicrobial biomaterial surfaces;
- Biodegradable and bioresorbable materials for tissue engineering and regenerative medicine;
- Hemocompatibility of materials for extracorporeal and cardiovascular devices;
- Computational modelling of biomaterial–biological environment interactions;
- Advanced microscopy and imaging techniques in biomaterial characterisation;
- Clinical translation of novel bioactive materials.
Dr. Sebastian Stach
Dr. Andrzej Swinarew
Guest Editors
Dr. Żaneta Garczyk-Mundała
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- biomaterials
- bioactivity
- surface analysis
- biocompatibility
- surface modification
- tissue engineering
- implants
- atomic force microscopy
- osseointegration
- hemocompatibility
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